2011
Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS)
Paroder-Belenitsky M, Maestas MJ, Dohán O, Nicola JP, Reyna-Neyra A, Follenzi A, Dadachova E, Eskandari S, Amzel LM, Carrasco N. Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS). Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 17933-17938. PMID: 22011571, PMCID: PMC3207644, DOI: 10.1073/pnas.1108278108.Peer-Reviewed Original ResearchConceptsAnion substratesThyroid hormone biosynthesisEnvironmental pollutant perchloratePlasma membraneOpen conformationHormone biosynthesisHomology model
2007
The Na+/I− symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate
Dohán O, Portulano C, Basquin C, Reyna-Neyra A, Amzel LM, Carrasco N. The Na+/I− symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20250-20255. PMID: 18077370, PMCID: PMC2154417, DOI: 10.1073/pnas.0707207104.Peer-Reviewed Original ResearchConceptsI- uptakeExposure of newbornsDifferent stoichiometriesIodine-containing thyroid hormonesPublic health impactStoichiometryMaternal milkLactating breastPerchlorateGreater health risksThyroid hormonesEnvironmental pollutant perchlorateDifferent substratesCNS developmentSuch exposureU.S. populationProper CNS developmentCompetitive inhibitorHealth impactsNewbornsKey plasma membrane proteinThyroidBreastHealth risksAnions