2002
Role of Lymphotoxin α in T-Cell Responses during an Acute Viral Infection
Suresh M, Lanier G, Large MK, Whitmire JK, Altman JD, Ruddle NH, Ahmed R. Role of Lymphotoxin α in T-Cell Responses during an Acute Viral Infection. Journal Of Virology 2002, 76: 3943-3951. PMID: 11907234, PMCID: PMC136110, DOI: 10.1128/jvi.76.8.3943-3951.2002.Peer-Reviewed Original ResearchConceptsT cell responsesCD8 T cellsLymphocytic choriomeningitis virusT cellsT cell activationLymphoid architectureMajor histocompatibility complex class I tetramersVirus-specific CD8 T cell responsesLCMV-specific CD8 T cellsLCMV-specific T-cell responsesVirus-specific CD8 T cellsAntigen-specific T cell responsesCD8 T cell responsesLCMV-specific T cellsT cell-mediated immunopathologyLTalpha-deficient miceClass I tetramersAcute viral infectionCD4 T cellsAdoptive transfer experimentsCell transfer experimentsLCMV clearanceNonlymphoid organsAdoptive transferAcute infection
2000
Kinetics and Cellular Origin of Cytokines in the Central Nervous System: Insight into Mechanisms of Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis
Juedes A, Hjelmström P, Bergman C, Neild A, Ruddle N. Kinetics and Cellular Origin of Cytokines in the Central Nervous System: Insight into Mechanisms of Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2000, 164: 419-426. PMID: 10605038, DOI: 10.4049/jimmunol.164.1.419.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCentral Nervous SystemChemokinesCytokinesEncephalomyelitis, Autoimmune, ExperimentalFemaleImmunophenotypingInflammation MediatorsInjections, SubcutaneousInterferon-gammaKineticsLymphocyte ActivationMacrophagesMiceMice, Inbred C57BLMicrogliaMolecular Sequence DataMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinSpleenTh1 CellsTh2 CellsTumor Necrosis Factor-alphaConceptsMyelin oligodendrocyte glycoproteinExperimental autoimmune encephalomyelitisAutoimmune encephalomyelitisOligodendrocyte glycoproteinTNF-alphaT cellsDay 7IFN-inducible protein-10TNF-alpha-producing cellsMonocyte chemotactic protein-1MOG35-55 peptideChronic clinical courseAnti-inflammatory cytokinesCD4 T cellsCourse of diseaseChemotactic protein-1Sensitive single-cell assayCellular originTNF-alpha productionRecruitment of macrophagesCentral nervous systemMOG35-55Clinical courseTh1 cytokinesTh2 cytokines