2003
Helicobacter-Induced Chronic Active Lymphoid Aggregates Have Characteristics of Tertiary Lymphoid Tissue
Shomer NH, Fox JG, Juedes AE, Ruddle NH. Helicobacter-Induced Chronic Active Lymphoid Aggregates Have Characteristics of Tertiary Lymphoid Tissue. Infection And Immunity 2003, 71: 3572-3577. PMID: 12761142, PMCID: PMC155770, DOI: 10.1128/iai.71.6.3572-3577.2003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigens, SurfaceAutoimmunityCell Adhesion MoleculesCell AggregationChemokine CCL21Chemokine CXCL13Chemokines, CCChemokines, CXCHelicobacter InfectionsHepatitis, ChronicImmunoglobulinsLiverLymphoid TissueMembrane ProteinsMiceMucoproteinsVascular Cell Adhesion Molecule-1ConceptsChronic active hepatitisTertiary lymphoid organsLymphoid organsActive hepatitisInflammatory lesionsHepatic inflammatory lesionsMucosal addressin cell adhesion moleculeTertiary lymphoid tissuePeripheral node addressinLiver cell suspensionsLiver tissue sectionsB220-positive B cellsChemokines SLCHepatic inflammationInflammatory infiltrateChronic autoimmunityLymphoid aggregatesLymphoid tissueFluorescence-activated cell sortingT cellsCell adhesion moleculeB cellsStromal cellsSmall venulesAdhesion moleculesEctopic LTαβ Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase
Drayton DL, Ying X, Lee J, Lesslauer W, Ruddle NH. Ectopic LTαβ Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase. Journal Of Experimental Medicine 2003, 197: 1153-1163. PMID: 12732657, PMCID: PMC2193975, DOI: 10.1084/jem.20021761.Peer-Reviewed Original ResearchConceptsHigh endothelial venulesPeripheral node addressinLymphoid organogenesisLT-alphaB cell compartmentalizationMucosal addressin cell adhesion moleculeAlpha betaLymph node functionB-cell areasAntigen presenting cellsLymphoid neogenesisPancreatic infiltratesPNAd expressionLymphoid chemokinesFDC networksMononuclear infiltrateAlpha micePresenting cellsEndothelial venulesCell adhesion moleculeCell accumulationLT-betaAdhesion moleculesNode functionPancreata
1999
Lymphoid neoorganogenesis
Ruddle N. Lymphoid neoorganogenesis. Immunologic Research 1999, 19: 119-125. PMID: 10493167, DOI: 10.1007/bf02786481.Peer-Reviewed Original ResearchConceptsVascular cell adhesion moleculeE-selectin adhesion moleculesIntercellular adhesion moleculePeripheral node addressinAdhesion moleculesKnockout miceTertiary lymphoid organsCellular adhesion moleculesNecrosis factor familyLymphoid organ developmentEndothelial cell lineAutoimmune diseasesChronic inflammationLymphoid organsLymphoid tissueCell adhesion moleculeLymphotoxinInflammationMultiple receptorsMicrobial infectionsCell linesMiceOrgan developmentFactor familyAddressin