Suppressor cells induced by total lymphoid irradiation affect proliferation and lymphokine production of murine T helper cell clones
Mate T, Ruddle N. Suppressor cells induced by total lymphoid irradiation affect proliferation and lymphokine production of murine T helper cell clones. International Journal Of Radiation Oncology • Biology • Physics 1987, 13: 61-68. PMID: 2948938, DOI: 10.1016/0360-3016(87)90261-6.Peer-Reviewed Original ResearchConceptsTotal lymphoid irradiationT helper cell clonesSuppressor cellsInterleukin-2Lymphoid irradiationT-helper cell proliferative responsesCell clonesT cell capacityT cell growth factorHelper T cellsT cell populationsCell proliferative responsesMarked inhibitory effectGamma-IFN releaseLympho-reticular tissuesCell growth factorMurine T helper cell clonesNodal irradiationType hypersensitivityAntigen responseImmune suppressionImmunosuppressive effectsLymphokine responsesAntigen presentationT cellsLymphotoxin: Cloning, Regulation and Mechanism of Killing
Ruddle N, Li C, Tang W, Gray P, McGrath K. Lymphotoxin: Cloning, Regulation and Mechanism of Killing. Novartis Foundation Symposia 1987, 131: 64-87. PMID: 3502460, DOI: 10.1002/9780470513521.ch6.Peer-Reviewed Original ResearchConceptsCDNA libraryBamHI fragmentMurine genomic libraryFull-length cDNACOS-1 cellsCell linesT cell linesNorthern blot analysisGenomic libraryMechanism of killingCDNA probeDNA fragmentationChromosome 17T cell receptorRNABlot analysisCDNAGenesCell receptorCell clonesCellsTarget cellsFragmentsMRNA expressionCloning