1997
Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection.
Soong L, Chang CH, Sun J, Longley BJ, Ruddle NH, Flavell RA, McMahon-Pratt D. Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection. The Journal Of Immunology 1997, 158: 5374-83. PMID: 9164958, DOI: 10.4049/jimmunol.158.11.5374.Peer-Reviewed Original ResearchConceptsII-/- miceLeishmania amazonensis infectionRag2-/- miceT cellsAmazonensis infectionMHC classL. amazonensis-infected miceWild-type C57BL/6 miceLarge ulcerating lesionsMonocytes/granulocytesRole of CD4Course of infectionMonocytes/macrophagesStrains of miceMHC class IWild-type CD4T cell developmentUlcerating lesionFunctional CD4Lymphocyte subsetsC57BL/6 miceTh1 cellsInflammatory responseLesion pathologyImmune response
1996
Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis Infection
Soong L, Xu J, Grewal I, Kima P, Sun J, Longley B, Ruddle N, McMahon-Pratt D, Flavell R. Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis Infection. Immunity 1996, 4: 263-273. PMID: 8624816, DOI: 10.1016/s1074-7613(00)80434-3.Peer-Reviewed Original ResearchConceptsCD40L-/- miceImmune responseCD40-CD40 ligand interactionCD40L knockout miceLeishmania amazonensis infectionProgressive ulcerative lesionTissue parasite burdenCD40-CD40L interactionCellular immune responsesProtective immune responseWild-type miceHost immune responseImpaired T cellNitric oxide productionAmazonensis infectionUlcerative lesionsInflammatory responseNecrosis factorCD40 ligandT cellsIFN-gammaKnockout miceMacrophage activationParasite burdenOxide production