2020
Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production
Truman LA, Bentley KL, Ruddle NH. Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production. European Journal Of Immunology 2020, 50: 418-425. PMID: 32012252, DOI: 10.1002/eji.201948300.Peer-Reviewed Original ResearchConceptsTertiary lymphoid organsLacrimal glandCervical lymphadenopathySjögren's syndromeLymphoid organsTear productionRole of lymphotoxinTLO formationAutoantibody titresMALT lymphomaLymphoid tissueTransgenic miceLymphotoxinMiceLymphadenopathyGlandSyndromeOrgansAutoimmunityMucosalLymphomaLTαTitresSalivaryLTβ
2016
Lymphotoxin
Ruddle N. Lymphotoxin. 2016, 466-475. DOI: 10.1016/b978-0-12-374279-7.10003-7.Peer-Reviewed Original ResearchTumor necrosis factorNFκB pathwayChronic inflammatory infiltrateAlternative NFκB pathwayMajor histocompatibility complexLymph nodesInflammatory infiltrateChemokine expressionChronic inflammationLymphoid organsNecrosis factorImmune responseCanonical NFκB pathwaySpecific antigenTNF receptorLymphotoxinLTβ receptorHistocompatibility complexTNF familyCulture supernatantsEmbryological developmentLymphocytesLTαCytotoxic activityReceptors
2014
Pillars article: Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994. 264: 703-707.
De Togni P, Goellner J, Ruddle NH, Streeter PR, Andrea F, Mariathasan S, Smith SC, Carlson R, Shornick LP, Strauss-Schoenberger J, Russell JH, Karr R, Chaplin DD. Pillars article: Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994. 264: 703-707. The Journal Of Immunology 2014, 192: 2010-4. PMID: 24563504.Peer-Reviewed Original Research
2011
Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein
Akirav EM, Xu Y, Ruddle NH. Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein. Journal Of Neuroimmunology 2011, 235: 33-39. PMID: 21550671, PMCID: PMC3157307, DOI: 10.1016/j.jneuroim.2011.03.013.Peer-Reviewed Original ResearchConceptsB cellsB cell-deficient μMT miceMyelin oligodendrocyte glycoproteinResident B cellsThymic B cellsCortico-medullary junctionMinor cell populationProduction of LTInsulin mRNA expressionΜMT miceEpithelial cell numberOligodendrocyte glycoproteinThymic expressionAntigen expressionMRNA expressionNormal tissuesCell populationsCell numberCellsExpressionLtUnexpected roleBiological roleLymphotoxinMice
1999
Lymphoid neoorganogenesis
Ruddle N. Lymphoid neoorganogenesis. Immunologic Research 1999, 19: 119-125. PMID: 10493167, DOI: 10.1007/bf02786481.Peer-Reviewed Original ResearchConceptsVascular cell adhesion moleculeE-selectin adhesion moleculesIntercellular adhesion moleculePeripheral node addressinAdhesion moleculesKnockout miceTertiary lymphoid organsCellular adhesion moleculesNecrosis factor familyLymphoid organ developmentEndothelial cell lineAutoimmune diseasesChronic inflammationLymphoid organsLymphoid tissueCell adhesion moleculeLymphotoxinInflammationMultiple receptorsMicrobial infectionsCell linesMiceOrgan developmentFactor familyAddressin
1996
Lymphoid Organogenesis and Inflammation Are Mediated by Lymphotoxin
Kratz A, Barten D, Campos-Neto A, Ruddle N. Lymphoid Organogenesis and Inflammation Are Mediated by Lymphotoxin. Serono Symposia USA 1996, 149-153. DOI: 10.1007/978-1-4612-2376-4_15.Peer-Reviewed Original Research
1994
Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin
De Togni P, Goellner J, Ruddle N, Streeter P, Fick A, Mariathasan S, Smith S, Carlson R, Shornick L, Strauss-Schoenberger J, Russell J, Karr R, Chaplin D. Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin. Science 1994, 264: 703-707. PMID: 8171322, DOI: 10.1126/science.8171322.Peer-Reviewed Original ResearchConceptsPeripheral lymphoid organsPeripheral bloodLymphoid organsT cellsDetectable lymph nodesT cell subsetsLymph nodesCD4-CD8Cell subsetsPeyer's patchesMice DeficientImmunoglobulin MWhite pulpLymphotoxinLytic functionNormal ratioAbnormal developmentSpleenStem cellsBloodNormal developmentOrgansCellsLymphocytesThymus
1986
Lymphotoxin production in AIDS
Ruddle N. Lymphotoxin production in AIDS. Trends In Immunology 1986, 7: 8-9. PMID: 25291416, DOI: 10.1016/0167-5699(86)90181-7.Peer-Reviewed Original Research
1985
A comparison of lysis mediated by Lyt 2+ TNP-specific cytotoxic-T-lymphocyte (CTL) lines with that mediated by rapidly internalized lymphotoxin-containing supernatant fluids: Evidence for a role of soluble mediators in CTL-mediated killing
Schmid D, Powell M, Mahoney K, Ruddle N. A comparison of lysis mediated by Lyt 2+ TNP-specific cytotoxic-T-lymphocyte (CTL) lines with that mediated by rapidly internalized lymphotoxin-containing supernatant fluids: Evidence for a role of soluble mediators in CTL-mediated killing. Cellular Immunology 1985, 93: 68-82. PMID: 3873290, DOI: 10.1016/0008-8749(85)90389-2.Peer-Reviewed Original ResearchConceptsLyt-2Soluble mediatorsT cell-mediated lysisCytotoxic T lymphocyte lineSpecific T cell linesTarget cellsCytotoxic T lymphocytesDose-dependent fashionSupernatant fluidT cell linesSyngeneic splenocytesAppropriate target cellsT lymphocytesCytoplasm of fibroblastsLymphotoxinMild hypotonic shockLytic processLethal hitPreliminary evidenceMediatorsHypotonic shockLethal effectsCellsFibroblastsOsmotic procedureLymphotoxin redux
Ruddle N. Lymphotoxin redux. Trends In Immunology 1985, 6: 156-159. PMID: 25289782, DOI: 10.1016/0167-5699(85)90144-6.Peer-Reviewed Original Research