1993
T Helper 1 (TH1) Functional Phenotype of Human Myelin Basic Protein-Specific T Lymphocytes
Voskuhl R, Martin R, Bergman C, Dalal M, Ruddle N, Mcfarland H. T Helper 1 (TH1) Functional Phenotype of Human Myelin Basic Protein-Specific T Lymphocytes. Autoimmunity 1993, 15: 137-143. PMID: 7692995, DOI: 10.3109/08916939309043888.Peer-Reviewed Original ResearchConceptsExperimental allergic encephalomyelitisMyelin basic proteinMultiple sclerosisT cell linesT cellsMyelin basic protein-specific T lymphocytesMBP-specific T cell linesMurine experimental allergic encephalomyelitisMBP-specific T cellsAntigen-specific cytotoxic activityFunctional phenotypeEncephalitogenic T cellsHuman T cell lineCell linesTh1 subtypeCandidate autoantigenAllergic encephalomyelitisAutoimmune diseasesInflammatory cellsTumor necrosisT lymphocytesInterleukin-4Animal modelsImmunodominant regionCurrent report
1985
A comparison of lysis mediated by Lyt 2+ TNP-specific cytotoxic-T-lymphocyte (CTL) lines with that mediated by rapidly internalized lymphotoxin-containing supernatant fluids: Evidence for a role of soluble mediators in CTL-mediated killing
Schmid D, Powell M, Mahoney K, Ruddle N. A comparison of lysis mediated by Lyt 2+ TNP-specific cytotoxic-T-lymphocyte (CTL) lines with that mediated by rapidly internalized lymphotoxin-containing supernatant fluids: Evidence for a role of soluble mediators in CTL-mediated killing. Cellular Immunology 1985, 93: 68-82. PMID: 3873290, DOI: 10.1016/0008-8749(85)90389-2.Peer-Reviewed Original ResearchConceptsLyt-2Soluble mediatorsT cell-mediated lysisCytotoxic T lymphocyte lineSpecific T cell linesTarget cellsCytotoxic T lymphocytesDose-dependent fashionSupernatant fluidT cell linesSyngeneic splenocytesAppropriate target cellsT lymphocytesCytoplasm of fibroblastsLymphotoxinMild hypotonic shockLytic processLethal hitPreliminary evidenceMediatorsHypotonic shockLethal effectsCellsFibroblastsOsmotic procedure
1980
Antigen-specific molecules from murine T lymphocytes and T cell hybridomas
Goodman J, Lewis G, Primi D, Hornbeck P, Ruddle N. Antigen-specific molecules from murine T lymphocytes and T cell hybridomas. Molecular Immunology 1980, 17: 933-945. PMID: 6163975, DOI: 10.1016/0161-5890(80)90042-5.Peer-Reviewed Original ResearchConceptsJ miceT cellsABA-specific T cellsAntigen-specific suppressor activitySuppressor T cell responseSuppressor T cellsT cell responsesAntigen-specific moleculesLight chain determinantsABA-protein conjugatesT cell moleculesT cell hybridomasIa markersMurine T lymphocytesT lymphocytesRosette formationCell responsesMajor idiotypeSerological analysisCell hybridomasBW 5147Suppressor activityCell lysatesCell moleculesHybridoma cell lines