2016
Lymphotoxin
Ruddle N. Lymphotoxin. 2016, 466-475. DOI: 10.1016/b978-0-12-374279-7.10003-7.Peer-Reviewed Original ResearchTumor necrosis factorNFκB pathwayChronic inflammatory infiltrateAlternative NFκB pathwayMajor histocompatibility complexLymph nodesInflammatory infiltrateChemokine expressionChronic inflammationLymphoid organsNecrosis factorImmune responseCanonical NFκB pathwaySpecific antigenTNF receptorLymphotoxinLTβ receptorHistocompatibility complexTNF familyCulture supernatantsEmbryological developmentLymphocytesLTαCytotoxic activityReceptors
2014
Lymphotoxin and TNF: How it all began—A tribute to the travelers
Ruddle NH. Lymphotoxin and TNF: How it all began—A tribute to the travelers. Cytokine & Growth Factor Reviews 2014, 25: 83-89. PMID: 24636534, PMCID: PMC4027955, DOI: 10.1016/j.cytogfr.2014.02.001.Peer-Reviewed Original Research
1993
Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.
Picarella DE, Kratz A, Li CB, Ruddle NH, Flavell RA. Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice. The Journal Of Immunology 1993, 150: 4136-50. PMID: 7682590, DOI: 10.4049/jimmunol.150.9.4136.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceCD4 AntigensCD8 AntigensCell Adhesion MoleculesDiabetes Mellitus, Type 1Histocompatibility Antigens Class IIHumansIntercellular Adhesion Molecule-1Islets of LangerhansKidneyLeukocyte Common AntigensLymphotoxin-alphaMiceMice, Inbred NODMice, TransgenicPancreatitisProtein Tyrosine Phosphatase, Non-Receptor Type 1Receptors, Interleukin-2Tumor Necrosis Factor-alphaUp-RegulationConceptsTNF-alphaTransgenic miceTNF-alpha transgenic miceInsulin-dependent diabetes mellitusAdhesion molecules VCAM-1Rat insulin II promoterTNF-alpha transgeneRole of TNFMurine TNF-alphaTumor necrosis factorRegulation of inflammationMHC class IReduced insulin contentPeri-insulitisIslet destructionDiabetes mellitusAutoimmune diseasesAlpha productionIslet endotheliumNecrosis factorT cellsICAM-1VCAM-1Insulin contentB cells
1987
Cytotoxic Factors Secreted by Cells Infected by Human Immunodeficiency Virus Type I
RATNER L, POLMAR S, PAUL N, RUDDLE N. Cytotoxic Factors Secreted by Cells Infected by Human Immunodeficiency Virus Type I. AIDS Research And Human Retroviruses 1987, 3: 147-155. PMID: 3497655, DOI: 10.1089/aid.1987.3.147.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type IVirus type IMononuclear cellsHIV-1Cytotoxic factorPeripheral blood mononuclear cellsHIV-1 infectionBlood mononuclear cellsHIV-1 replicationTumor necrosis factorCell-derived factorCell linesMonocytoid cell linesType ICytotoxic activityAspects of infectionSystemic manifestationsNecrosis factorUninfected counterpartsVirus replicationConditioned mediaCell killingFibroblast cell lineInfectionMurine fibroblast cell line