2014
A Humanized Mouse Model of Autoimmune Insulitis
Milam A, Maher SE, Gibson JA, Lebastchi J, Wen L, Ruddle NH, Herold KC, Bothwell AL. A Humanized Mouse Model of Autoimmune Insulitis. Diabetes 2014, 63: 1712-1724. PMID: 24478396, PMCID: PMC3994947, DOI: 10.2337/db13-1141.Peer-Reviewed Original ResearchConceptsT cellsDiabetic donorsInsulin stainingMouse modelAntigen-pulsed cellsAutoantigen-derived peptidesNOD mouse modelHumanized mouse modelType 1 diabetesPancreatic β-cellsT cell linesHuman T cellsIslet infiltrationAutoimmune diabetesNOD-SCIDAutoimmune insulitisHuman diabetesDestructive infiltrationMouse isletsMechanism of inductionΒ-cellsDiabetesDiabetes researchDisease modelsInsulitis
1998
T helper cell differentiation in multiple sclerosis and autoimmunity
Martin R, Ruddle N, Reingold S, Hafler D. T helper cell differentiation in multiple sclerosis and autoimmunity. Trends In Immunology 1998, 19: 495-498. PMID: 9818541, DOI: 10.1016/s0167-5699(98)01345-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmunityCell DifferentiationCytokinesHumansMultiple SclerosisT-Lymphocyte SubsetsT-Lymphocytes, Helper-Inducer
1997
LYMPHOTOXIN-β AND TNF REGULATION IN T CELL SUBSETS: DIFFERENTIAL EFFECTS OF PGE2
Ferreri N, Millet I, Askari B, Magnani P, Ruddle N. LYMPHOTOXIN-β AND TNF REGULATION IN T CELL SUBSETS: DIFFERENTIAL EFFECTS OF PGE2. Cytokine 1997, 9: 157-165. PMID: 9126704, DOI: 10.1006/cyto.1996.0150.Peer-Reviewed Original ResearchConceptsT cell subsetsTumor necrosis factor alphaCell subsetsTNF mRNA accumulationProstaglandin E2Th2 cellsLT-betaCytokine productionTh1 cellsIL-3Effect of PGE2IL-4 mRNANecrosis factor alphaTh2 T cell clonesT cell clonesTh2 T cellsLT-beta mRNAOnly cytokineIL-4Factor alphaT cellsTNF regulationImmune responseInterleukin-4Lymphotoxin beta
1994
Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin
De Togni P, Goellner J, Ruddle N, Streeter P, Fick A, Mariathasan S, Smith S, Carlson R, Shornick L, Strauss-Schoenberger J, Russell J, Karr R, Chaplin D. Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin. Science 1994, 264: 703-707. PMID: 8171322, DOI: 10.1126/science.8171322.Peer-Reviewed Original ResearchConceptsPeripheral lymphoid organsPeripheral bloodLymphoid organsT cellsDetectable lymph nodesT cell subsetsLymph nodesCD4-CD8Cell subsetsPeyer's patchesMice DeficientImmunoglobulin MWhite pulpLymphotoxinLytic functionNormal ratioAbnormal developmentSpleenStem cellsBloodNormal developmentOrgansCellsLymphocytesThymus