2003
Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice
Oliver AR, Lyon GM, Ruddle NH. Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice. The Journal Of Immunology 2003, 171: 462-468. PMID: 12817031, DOI: 10.4049/jimmunol.171.1.462.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigen PresentationAutoantibodiesB-LymphocytesCell MovementDose-Response Relationship, ImmunologicEncephalomyelitis, Autoimmune, ExperimentalFemaleGlycoproteinsHumansImmunoglobulin GInjections, IntramuscularInterferon-gammaInterleukin-13MiceMice, Inbred C57BLMice, Mutant StrainsMolecular Sequence DataMyelin-Oligodendrocyte GlycoproteinPeptide FragmentsRatsSpecies SpecificitySpinal CordConceptsExperimental autoimmune encephalomyelitisMyelin oligodendrocyte glycoproteinRat myelin oligodendrocyte glycoproteinHuman myelin oligodendrocyte glycoproteinMOG 35C57BL/6 miceMOG proteinAutoimmune encephalomyelitisOligodendrocyte glycoproteinB cellsCell responsesEncephalitogenic T cell responsesB cell-deficient miceB cell dependenceCell-deficient miceT cell responsesB cell responsesDifferent pathogenic mechanismsCNS infiltratesIL-13T cellsSpleen cellsIFN-gammaIgG subclassesAg presentation
2001
Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches
Spahn T, Fontana A, Faria A, Slavin A, Eugster H, Zhang X, Koni P, Ruddle N, Flavell R, Rennert P, Weiner H. Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches. European Journal Of Immunology 2001, 31: 1278-1287. PMID: 11298355, DOI: 10.1002/1521-4141(200104)31:4<1278::aid-immu1278>3.0.co;2-a.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsAntibodiesDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFecesGene DeletionHypersensitivity, DelayedImmune ToleranceImmunity, MucosalImmunoglobulin AInterferon-gammaInterleukin-2Lymph NodesLymphotoxin-alphaMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutOvalbuminPeyer's PatchesSignal TransductionTumor Necrosis Factor-alphaConceptsGut-associated lymphoid tissueMesenteric lymph nodesOral toleranceLow-dose oral toleranceDelayed-type hypersensitivity responseFecal IgA productionLTbeta-/- miceOral tolerance inductionLamina propria lymphocytesIntact immune systemCellular immune responsesPeripheral lymphoid organsIFN-gamma productionTumor necrosis factor familyProcessing of antigensNecrosis factor familySystemic hyporesponsivenessLymph nodesHypersensitivity responseTolerance inductionIgA productionIntraperitoneal administrationLymphoid organsLymphoid tissuePeyer's patches