1997
Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection.
Soong L, Chang CH, Sun J, Longley BJ, Ruddle NH, Flavell RA, McMahon-Pratt D. Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection. The Journal Of Immunology 1997, 158: 5374-83. PMID: 9164958, DOI: 10.4049/jimmunol.158.11.5374.Peer-Reviewed Original ResearchConceptsII-/- miceLeishmania amazonensis infectionRag2-/- miceT cellsAmazonensis infectionMHC classL. amazonensis-infected miceWild-type C57BL/6 miceLarge ulcerating lesionsMonocytes/granulocytesRole of CD4Course of infectionMonocytes/macrophagesStrains of miceMHC class IWild-type CD4T cell developmentUlcerating lesionFunctional CD4Lymphocyte subsetsC57BL/6 miceTh1 cellsInflammatory responseLesion pathologyImmune response
1996
Leishmania‐infected macrophages sequester endogenously synthesized parasite antigens from presentation to CD4+ T cells
Kima P, Soong L, Chicharro C, Ruddle N, McMahon‐Pratt D. Leishmania‐infected macrophages sequester endogenously synthesized parasite antigens from presentation to CD4+ T cells. European Journal Of Immunology 1996, 26: 3163-3169. PMID: 8977318, DOI: 10.1002/eji.1830261249.Peer-Reviewed Original ResearchConceptsT cellsAntigen presentationParasite antigensMajor histocompatibility complex (MHC) class II moleculesMHC class II pathwayActivation of CD4Peritoneal exudate cellsClass II pathwayClass II moleculesHost immune systemCell linesT cell linesAmastigote antigensLeishmania antigenAntigen sequestrationLeishmania amastigotesMacrophage cell lineExudate cellsCD4Immune systemLive parasitesParasite moleculesAntigenMacrophagesInfected cells