2001
Resident and Infiltrating Central Nervous System APCs Regulate the Emergence and Resolution of Experimental Autoimmune Encephalomyelitis
Juedes A, Ruddle N. Resident and Infiltrating Central Nervous System APCs Regulate the Emergence and Resolution of Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2001, 166: 5168-5175. PMID: 11290800, DOI: 10.4049/jimmunol.166.8.5168.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigen PresentationAntigen-Presenting CellsB7-1 AntigenBrainCell LineCell MovementDown-RegulationEncephalomyelitis, Autoimmune, ExperimentalFemaleGrowth InhibitorsHistocompatibility Antigens Class IHistocompatibility Antigens Class IILymphocyte ActivationMacromolecular SubstancesMacrophagesMiceMice, Inbred C57BLMice, KnockoutMicrogliaMolecular Sequence DataMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinNitric OxideSpinal CordT-LymphocytesConceptsExperimental autoimmune encephalomyelitisT cell proliferationT cellsT cell linesCNS APCCNS APCsAutoimmune encephalomyelitisMHC-IITarget organsInducible NO synthase-deficient miceT cell cytokine productionTh1 T cellsAutoreactive T cellsCell cytokine productionIFN-gamma productionB7-1 expressionSynthase-deficient miceCell proliferationMac-1 cellsCell linesInitiation of diseaseProduction of NOResident microgliaMyelin oligodendrocyteCytokine production
2000
Kinetics and Cellular Origin of Cytokines in the Central Nervous System: Insight into Mechanisms of Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis
Juedes A, Hjelmström P, Bergman C, Neild A, Ruddle N. Kinetics and Cellular Origin of Cytokines in the Central Nervous System: Insight into Mechanisms of Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2000, 164: 419-426. PMID: 10605038, DOI: 10.4049/jimmunol.164.1.419.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCentral Nervous SystemChemokinesCytokinesEncephalomyelitis, Autoimmune, ExperimentalFemaleImmunophenotypingInflammation MediatorsInjections, SubcutaneousInterferon-gammaKineticsLymphocyte ActivationMacrophagesMiceMice, Inbred C57BLMicrogliaMolecular Sequence DataMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinSpleenTh1 CellsTh2 CellsTumor Necrosis Factor-alphaConceptsMyelin oligodendrocyte glycoproteinExperimental autoimmune encephalomyelitisAutoimmune encephalomyelitisOligodendrocyte glycoproteinTNF-alphaT cellsDay 7IFN-inducible protein-10TNF-alpha-producing cellsMonocyte chemotactic protein-1MOG35-55 peptideChronic clinical courseAnti-inflammatory cytokinesCD4 T cellsCourse of diseaseChemotactic protein-1Sensitive single-cell assayCellular originTNF-alpha productionRecruitment of macrophagesCentral nervous systemMOG35-55Clinical courseTh1 cytokinesTh2 cytokines
1996
Leishmania‐infected macrophages sequester endogenously synthesized parasite antigens from presentation to CD4+ T cells
Kima P, Soong L, Chicharro C, Ruddle N, McMahon‐Pratt D. Leishmania‐infected macrophages sequester endogenously synthesized parasite antigens from presentation to CD4+ T cells. European Journal Of Immunology 1996, 26: 3163-3169. PMID: 8977318, DOI: 10.1002/eji.1830261249.Peer-Reviewed Original ResearchConceptsT cellsAntigen presentationParasite antigensMajor histocompatibility complex (MHC) class II moleculesMHC class II pathwayActivation of CD4Peritoneal exudate cellsClass II pathwayClass II moleculesHost immune systemCell linesT cell linesAmastigote antigensLeishmania antigenAntigen sequestrationLeishmania amastigotesMacrophage cell lineExudate cellsCD4Immune systemLive parasitesParasite moleculesAntigenMacrophagesInfected cells
1972
Approaches to the Quantitative Analysis of Delayed Hypersensitivity
Ruddle N. Approaches to the Quantitative Analysis of Delayed Hypersensitivity. Current Topics In Microbiology And Immunology 1972, 57: 75-110. PMID: 4554356, DOI: 10.1007/978-3-642-65297-4_3.Peer-Reviewed Original Research