2012
Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response
Kuerten S, Schickel A, Kerkloh C, Recks MS, Addicks K, Ruddle NH, Lehmann PV. Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response. Acta Neuropathologica 2012, 124: 861-873. PMID: 22842876, DOI: 10.1007/s00401-012-1023-3.Peer-Reviewed Original ResearchConceptsTertiary lymphoid organsExperimental autoimmune encephalomyelitisMyelin-specific T cell responseCentral nervous systemB cell aggregatesT cell responsesMultiple sclerosisB cell aggregationDeterminant spreadingB cellsCell responsesActive immune responseMyelin basic proteinLymphoid neogenesisAutoimmune encephalomyelitisMS patientsAggressive diseaseAutoimmune pathologyPatient populationLymphoid organsDisease onsetDisease progressionT cellsImmune responsePathogenic contribution
2005
Pathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiology
Marta CB, Oliver AR, Sweet RA, Pfeiffer SE, Ruddle NH. Pathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiology. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13992-13997. PMID: 16172404, PMCID: PMC1236555, DOI: 10.1073/pnas.0504979102.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsAutoantibodiesB-LymphocytesEncephalomyelitis, Autoimmune, ExperimentalGlycosylationHumansImmunizationImmunodominant EpitopesImmunoglobulin GMiceMice, Inbred C57BLMyelin ProteinsMyelin SheathMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinOligodendrogliaProlineRatsSerineConceptsHuman myelin oligodendrocyte glycoproteinMyelin oligodendrocyte glycoproteinExperimental autoimmune encephalomyelitisAnti-MOG antibodiesMultiple sclerosis patientsSclerosis patientsMouse myelin oligodendrocyte glycoproteinB cell-deficient miceMyelin oligodendrocyte glycoprotein antibodyB cell requirementCell-deficient miceAutoimmune encephalomyelitisAntibody pathogenicityPathogenic IgGC57BL/6 miceGlycoprotein antibodiesControl subjectsOligodendrocyte glycoproteinOnly immunizationMOG proteinHigh titersComparable titersMyelin componentsOligodendrocyte physiologyAntigenic determinants