Protein Kinase C-Mediated Phosphorylation of the Leukemia-Associated HOXA9 Protein Impairs Its DNA Binding Ability and Induces Myeloid Differentiation
Vijapurkar U, Fischbach N, Shen W, Brandts C, Stokoe D, Lawrence HJ, Largman C. Protein Kinase C-Mediated Phosphorylation of the Leukemia-Associated HOXA9 Protein Impairs Its DNA Binding Ability and Induces Myeloid Differentiation. Molecular And Cellular Biology 2004, 24: 3827-3837. PMID: 15082777, PMCID: PMC387750, DOI: 10.1128/mcb.24.9.3827-3837.2004.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBone Marrow CellsCasein Kinase IICell DifferentiationCell LineDNA-Binding ProteinsEnzyme ActivationHomeodomain ProteinsIsoenzymesLeukemia, MyeloidMiceMolecular Sequence DataMyeloid CellsPhorbol EstersPhosphorylationProtein BindingProtein Kinase CProtein Serine-Threonine KinasesSerineConceptsProtein kinase CProtein Kinase C-Mediated PhosphorylationMyeloid differentiationCasein kinase IIMurine bone marrow cellsN-terminal regionMurine marrow cellsHematopoietic cell linesDNA binding abilityHigh-level expressionHOXA9 proteinCooperative DNAEndogenous Hoxa9Specific PKC inhibitorMarrow cellsDNA bindingConsensus sequenceKinase IIProtein impairsMolecular mechanismsKinase CHOXA9 expressionHOXA9HOXA9 overexpressionPhosphorylation