HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo
Fischbach NA, Rozenfeld S, Shen W, Fong S, Chrobak D, Ginzinger D, Kogan SC, Radhakrishnan A, Le Beau MM, Largman C, Lawrence HJ. HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo. Blood 2004, 105: 1456-1466. PMID: 15522959, DOI: 10.1182/blood-2004-04-1583.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsBone Marrow CellsCell DifferentiationCell Line, TransformedCell ProliferationCell Transformation, NeoplasticErythropoiesisFemaleHomeodomain ProteinsKaryotypingLeukemia, MyeloidLymphopoiesisMiceMice, CongenicMice, Inbred C57BLMyeloid Ecotropic Viral Integration Site 1 ProteinMyeloid Progenitor CellsNeoplasm ProteinsPhenotypeTime FactorsConceptsHematopoietic stem cellsMurine bone marrowPre-B-cell leukemia transcription factor 1Potential cooperative interactionsHox gene expressionMyelomonocytic precursorsHematopoietic stem cell expansionStructure-function relationshipsStem cell expansionHox genesTranscription factor 1Homeobox genesHox familyHuman myeloid leukemiaDNA bindingGene expressionMalignant hematopoiesisHOXB6Gene transferAberrant activationMonocytic differentiationCell expansionDirect interactionStem cellsHuman acute myeloid leukemiaProtein Kinase C-Mediated Phosphorylation of the Leukemia-Associated HOXA9 Protein Impairs Its DNA Binding Ability and Induces Myeloid Differentiation
Vijapurkar U, Fischbach N, Shen W, Brandts C, Stokoe D, Lawrence HJ, Largman C. Protein Kinase C-Mediated Phosphorylation of the Leukemia-Associated HOXA9 Protein Impairs Its DNA Binding Ability and Induces Myeloid Differentiation. Molecular And Cellular Biology 2004, 24: 3827-3837. PMID: 15082777, PMCID: PMC387750, DOI: 10.1128/mcb.24.9.3827-3837.2004.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBone Marrow CellsCasein Kinase IICell DifferentiationCell LineDNA-Binding ProteinsEnzyme ActivationHomeodomain ProteinsIsoenzymesLeukemia, MyeloidMiceMolecular Sequence DataMyeloid CellsPhorbol EstersPhosphorylationProtein BindingProtein Kinase CProtein Serine-Threonine KinasesSerineConceptsProtein kinase CProtein Kinase C-Mediated PhosphorylationMyeloid differentiationCasein kinase IIMurine bone marrow cellsN-terminal regionMurine marrow cellsHematopoietic cell linesDNA binding abilityHigh-level expressionHOXA9 proteinCooperative DNAEndogenous Hoxa9Specific PKC inhibitorMarrow cellsDNA bindingConsensus sequenceKinase IIProtein impairsMolecular mechanismsKinase CHOXA9 expressionHOXA9HOXA9 overexpressionPhosphorylation