2023
Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study
Vollmar A, Rattray N, Cai Y, Jain A, Yan H, Deziel N, Calafat A, Wilcox A, Jukic A, Johnson C. Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study. Environmental Health Perspectives 2023, 131: 097006. PMID: 37702489, PMCID: PMC10498870, DOI: 10.1289/ehp12125.Peer-Reviewed Original ResearchConceptsUrinary paraben concentrationsDiet-related metabolitesEarly Pregnancy StudyUrinary metabolomePregnancy StudyParaben concentrationsReproductive functionMultivariable linear regressionFemale reproductive functionDietary exposure assessmentUltrahigh-performance liquid chromatography-quadrupole timeMetabolomic analysisParaben exposureProspective cohortLiquid chromatography-quadrupole timeOrthogonal partial least squares discriminant analysisPericonceptional periodPotential confoundersUrinary concentrationsMetabolomic markersNutritional epidemiologyUnivariate statistical analysisExposure informationCritical windowUrine samples
2022
Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort
Luo J, Ramlau-Hansen CH, Kesmodel US, Xiao J, Vasiliou V, Deziel NC, Zhang Y, Olsen J, Liew Z. Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort. Environmental Health Perspectives 2022, 130: 017006. PMID: 35080464, PMCID: PMC8791068, DOI: 10.1289/ehp9478.Peer-Reviewed Original ResearchConceptsDanish National Birth CohortMaternal alcohol intakePrenatal PFAS exposurePalpebral fissure lengthShorter palpebral fissure lengthNational Birth CohortYears of agePFAS exposureSecond tertileAlcohol intakePrenatal exposureOdds ratioBirth cohortSpecific neurologic deficitsConfidence intervalsFetal brain developmentSex-specific associationsNeurologic deficitsFirst trimesterPotential confoundersNeurodevelopmental effectsAlcohol exposureStratified analysisNormal groupMultinomial logistic regression
2020
Unconventional oil and gas development and health outcomes: A scoping review of the epidemiological research
Deziel NC, Brokovich E, Grotto I, Clark CJ, Barnett-Itzhaki Z, Broday D, Agay-Shay K. Unconventional oil and gas development and health outcomes: A scoping review of the epidemiological research. Environmental Research 2020, 182: 109124. PMID: 32069745, DOI: 10.1016/j.envres.2020.109124.Peer-Reviewed Original ResearchConceptsHealth outcomesLow birth weightAdverse birth outcomesAdverse health outcomesFull-text evaluationOutcomes of interestHuman health outcomesAsthma exacerbationsPreterm deliveryPregnancy outcomesBirth outcomesPotential confoundersBirth weightBody of evidenceCancer incidenceEligible studiesExposure assessment methodologyPotential environmental health hazardInclusion criteriaStudy populationEpidemiological studiesExposure assessment approachHealth problemsEnvironmental health hazardsSignificant association
2018
A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women
Deziel NC, Yi H, Stapleton HM, Huang H, Zhao N, Zhang Y. A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women. BMC Cancer 2018, 18: 637. PMID: 29871608, PMCID: PMC5989427, DOI: 10.1186/s12885-018-4553-9.Peer-Reviewed Original ResearchConceptsCase-control studyThyroid cancer riskPFR exposureThyroid cancerPFR metabolitesOdds ratioCancer riskPapillary thyroid cancer casesUrinary biomarker measurementsTime of diagnosisLarger tumor sizeCancer case-control studySpot urine samplesThyroid cancer casesPapillary thyroid cancer riskTumor sizePotential confoundersThyroid hormone regulationUrinary concentrationsCancer casesMultiple linear regression analysisFemale controlsLinear regression analysisBackgroundGrowing evidenceBiomarker measurementsShale gas activity and increased rates of sexually transmitted infections in Ohio, 2000–2016
Deziel NC, Humeau Z, Elliott EG, Warren JL, Niccolai LM. Shale gas activity and increased rates of sexually transmitted infections in Ohio, 2000–2016. PLOS ONE 2018, 13: e0194203. PMID: 29570712, PMCID: PMC5865738, DOI: 10.1371/journal.pone.0194203.Peer-Reviewed Original ResearchConceptsMixed-effects Poisson regression modelsAnnual rate ratiosCases of chlamydiaRate ratioRates of chlamydiaRates of gonorrheaCommunity health effortsPoisson regression modelsPotential confoundersSTI ratesHealth effortsGonorrheaReportable STIsChlamydiaEcologic studySyphilisConfidence intervalsOhio DepartmentInfectionSecular trends
2017
Occupational exposure to pesticides and other biocides and risk of thyroid cancer
Zeng F, Lerro C, Lavoué J, Huang H, Siemiatycki J, Zhao N, Ma S, Deziel NC, Friesen MC, Udelsman R, Zhang Y. Occupational exposure to pesticides and other biocides and risk of thyroid cancer. Occupational And Environmental Medicine 2017, 74: 502. PMID: 28202579, PMCID: PMC5572578, DOI: 10.1136/oemed-2016-103931.Peer-Reviewed Original ResearchConceptsThyroid cancerOccupational exposurePopulation-based case-control studyIncident thyroid cancer casesUnconditional logistic regression modelsCase-control studyPapillary thyroid cancerThyroid cancer casesJob-exposure matrixLogistic regression modelsHigher cumulative probabilityPotential confoundersThyroid microcarcinomaCancer casesHigh riskSignificant associationCancerObserved associationsCumulative probabilityStrong associationRiskAssociationExposureFurther investigationRegression models