2024
Using a Bayesian analytic approach to identify county-level ecological factors associated with survival among individuals with early-onset colorectal cancer
Siddique S, Baum L, Deziel N, Kelly J, Warren J, Ma X. Using a Bayesian analytic approach to identify county-level ecological factors associated with survival among individuals with early-onset colorectal cancer. PLOS ONE 2024, 19: e0311540. PMID: 39471191, PMCID: PMC11521299, DOI: 10.1371/journal.pone.0311540.Peer-Reviewed Original ResearchConceptsAge-of-onset colorectal cancerEarly-onset colorectal cancerEnd Results Program dataCenters for Disease Control and Prevention dataCounty-level factorsColorectal cancerHealth risk behaviorsIdentified principal componentsOdds of survivalPreventive servicesSurvival disparitiesLinear mixed modelsEOCRCChronic diseasesPreventive factorsUS countiesSalt Lake CountyCA residentsRisk behaviorsUnited StatesProgram dataCounty-levelOlder ageBayesian analytical approachYounger ageDelineating Urbanicity and Rurality: Impact on Environmental Exposure Assessment
Song Y, Deziel N, Bell M. Delineating Urbanicity and Rurality: Impact on Environmental Exposure Assessment. Environmental Science And Technology 2024, 58: 19178-19188. PMID: 39412270, DOI: 10.1021/acs.est.4c06942.Peer-Reviewed Original ResearchConceptsEnvironmental exposuresEnvironmental exposure assessmentExposure of particulate matterUrban/rural disparitiesDemographic compositionHealth StudyHealth researchPopulation-basedClassification systemExposure assessmentSpatial patternsHealth impactsRural areasHealthRuralParticulate matterLand surface temperatureWest VirginiaUnited StatesSurface temperatureUrbanizationResearch questionsAssessmentDisparitiesExposureHigh ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study
Rogne T, Wang R, Wang P, Deziel N, Metayer C, Wiemels J, Chen K, Warren J, Ma X. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. The Lancet Planetary Health 2024, 8: e506-e514. PMID: 38969477, PMCID: PMC11260908, DOI: 10.1016/s2542-5196(24)00121-9.Peer-Reviewed Original ResearchConceptsRisk of childhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLatino childrenNon-Latino white childrenAssociated with risk of adverse pregnancy outcomesCalifornia Cancer RegistryRisk of acute lymphoblastic leukemiaCalifornia birth recordsRisk of adverse pregnancy outcomesPre-pregnancy periodAssociated with riskBayesian meta-regressionNational Institutes of HealthCancer RegistryCases of childhood acute lymphoblastic leukemiaNational Center for Advancing Translational SciencesAdverse pregnancy outcomesAcute lymphoblastic leukemia casesInstitutes of HealthInvestigation of mechanistic pathwaysBirth recordsGestational weeks 8Pre-pregnancyNitrate exposure from drinking water and dietary sources among Iowa farmers using private wells
Skalaban T, Thompson D, Madrigal J, Blount B, Espinosa M, Kolpin D, Deziel N, Jones R, Beane Freeman L, Hofmann J, Ward M. Nitrate exposure from drinking water and dietary sources among Iowa farmers using private wells. The Science Of The Total Environment 2024, 919: 170922. PMID: 38350573, DOI: 10.1016/j.scitotenv.2024.170922.Peer-Reviewed Original ResearchConceptsMaximum contaminant levelUrinary nitrate concentrationDietary intakeNitrate concentrationsNitrate excretionNitrate exposureDietary nitrateDrinking waterDietary assessment toolsPrivate wellsAssociated with adverse health risksVulnerable to nitrate contaminationWater nitrate concentrationsNitrate ingestionAdverse health risksAgricultural Health StudyDrinking water intakeMedian intakeProspective cohortUrinary nitrateDietary nitrate ingestionContamination levelsNitrate contaminationNitrate intakeHealth StudyAssessing exposure and health consequences of chemicals in drinking water in the 21st Century
Deziel N, Villanueva C. Assessing exposure and health consequences of chemicals in drinking water in the 21st Century. Journal Of Exposure Science & Environmental Epidemiology 2024, 34: 1-2. PMID: 38429481, DOI: 10.1038/s41370-024-00639-0.Peer-Reviewed Original ResearchDrinking WaterHumans
2023
Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study
Rosen Vollmar A, Lin E, Nason S, Santiago K, Johnson C, Ma X, Godri Pollitt K, Deziel N. Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 737-747. PMID: 37730931, PMCID: PMC10541328, DOI: 10.1038/s41370-023-00603-4.Peer-Reviewed Original ResearchConceptsThyroid hormone concentrationsNeonatal characteristicsThyroid hormone measurementsHormone concentrationsThyroid hormonesBlood spotsPilot studyNewborn DBSHormone measurementsPopulation-based studyThyroid hormone levelsEnvironmental risk factorsPFAS concentrationsNewborn screening testNon-parametric WilcoxonThyroid diseaseRisk factorsHormone levelsKruskal-Wallis testPFAS exposureThyroid hormone dataScreening testNeonatal DBSEnvironmental exposuresPerformance liquid chromatography-mass spectrometryUrinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study
Vollmar A, Rattray N, Cai Y, Jain A, Yan H, Deziel N, Calafat A, Wilcox A, Jukic A, Johnson C. Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study. Environmental Health Perspectives 2023, 131: 097006. PMID: 37702489, PMCID: PMC10498870, DOI: 10.1289/ehp12125.Peer-Reviewed Original ResearchConceptsUrinary paraben concentrationsDiet-related metabolitesEarly Pregnancy StudyUrinary metabolomePregnancy StudyParaben concentrationsReproductive functionMultivariable linear regressionFemale reproductive functionDietary exposure assessmentUltrahigh-performance liquid chromatography-quadrupole timeMetabolomic analysisParaben exposureProspective cohortLiquid chromatography-quadrupole timeOrthogonal partial least squares discriminant analysisPericonceptional periodPotential confoundersUrinary concentrationsMetabolomic markersNutritional epidemiologyUnivariate statistical analysisExposure informationCritical windowUrine samplesResidential proximity to unconventional oil and gas development and birth defects in Ohio
Gaughan C, Sorrentino K, Liew Z, Johnson N, Clark C, Soriano M, Plano J, Plata D, Saiers J, Deziel N. Residential proximity to unconventional oil and gas development and birth defects in Ohio. Environmental Research 2023, 229: 115937. PMID: 37076028, PMCID: PMC10198955, DOI: 10.1016/j.envres.2023.115937.Peer-Reviewed Original ResearchConceptsNeural tube defectsCertain birth defectsBirth defectsOdds ratioRegistry-based cohort studyTube defectsConfidence intervalsResidential proximityState birth recordsBirth defect typeState surveillance systemsMaternal residential proximityLimb reduction defectsCohort studyUnexposed mothersStructural birth defectsLive birthsInfant sexBirth recordsSpina bifidaReduction defectsFemale offspringDevelopmental toxicantsExposure metricsHealth risks of heavy metals in food and their economic burden in Armenia
Pipoyan D, Stepanyan S, Beglaryan M, Stepanyan S, Mendelsohn R, Deziel N. Health risks of heavy metals in food and their economic burden in Armenia. Environment International 2023, 172: 107794. PMID: 36758298, DOI: 10.1016/j.envint.2023.107794.Peer-Reviewed Original ResearchConceptsHeavy metal intakeBenchmark dose levelsBlood pressureLead exposureEconomic burdenDose levelsDietary exposureEuropean Food Safety AuthorityAdverse health impactsDiet surveyDaily intakeExcess exposureConsumer safety concernsFood Safety AuthorityHealth impactsHealth risksSafety concernsIntakeLower IQ levelsExposureSpecific pathwaysExposure valuesSafety AuthorityPopulationMetal intake
2022
Urinary phenol concentrations and fecundability and early pregnancy loss
Vollmar A, Weinberg C, Baird D, Wilcox A, Calafat A, Deziel N, Johnson C, Jukic A. Urinary phenol concentrations and fecundability and early pregnancy loss. Human Reproduction 2022, 38: 139-155. PMID: 36346334, PMCID: PMC10089295, DOI: 10.1093/humrep/deac230.Peer-Reviewed Original ResearchConceptsEarly pregnancy lossPregnancy lossUrinary phenol concentrationsIntraclass correlation coefficientMenstrual cycleNational InstituteDaily first-morning urine specimensPhenol exposureEnvironmental Health SciencesFirst morning urine specimensLogistic regressionSTUDY FUNDING/COMPETINGMultivariable logistic regressionPARTICIPANTS/MATERIALSROLE OF CHANCEIntramural Research ProgramClinical miscarriageProspective cohortIncreased oddsLive birthsEpidemiologic studiesUrine specimensHealth SciencesEndocrine-disrupting potentialReproductive functionHemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study
Jain A, Morris M, Lin EZ, Khan SA, Ma X, Deziel NC, Godri Pollitt KJ, Johnson CH. Hemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study. The Science Of The Total Environment 2022, 854: 158716. PMID: 36113793, DOI: 10.1016/j.scitotenv.2022.158716.Peer-Reviewed Original ResearchUnconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017
Clark CJ, Johnson NP, Soriano M, Warren JL, Sorrentino KM, Kadan-Lottick NS, Saiers JE, Ma X, Deziel NC. Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017. Environmental Health Perspectives 2022, 130: 087001. PMID: 35975995, PMCID: PMC9383266, DOI: 10.1289/ehp11092.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCase-control studyOdds ratioChildhood leukemiaLymphoblastic leukemiaPerinatal windowRegistry-based case-control studyChildhood acute lymphoblastic leukemiaConfidence intervalsResidential proximityChildren ages 2Risk factorsMaternal raceChild healthExposure windowsSocio-economic statusPotential associationLeukemiaLogistic regressionAge 2Birth yearCommon formBirth residenceDevelopment exposureOddsRegional Scale Assessment of Shallow Groundwater Vulnerability to Contamination from Unconventional Hydrocarbon Extraction
Soriano MA, Deziel NC, Saiers JE. Regional Scale Assessment of Shallow Groundwater Vulnerability to Contamination from Unconventional Hydrocarbon Extraction. Environmental Science And Technology 2022, 56: 12126-12136. PMID: 35960643, PMCID: PMC9454823, DOI: 10.1021/acs.est.2c00470.Peer-Reviewed Original ResearchConceptsGroundwater vulnerabilityGroundwater contamination riskRegional-scale assessmentEnvironmental justice issuesUOG extractionShallow groundwaterSurface spillsSpatial transferabilityDomestic water wellsNortheastern USAContaminant transport processesGroundwater monitoringContamination riskStudy areaUnconventional hydrocarbon extractionScale assessmentDomestic purposesWater wellsContaminationSubsurface leakageVulnerability predictionHydrocarbon extractionModeling frameworkRegional modelGroundwater flowA Task-Specific Algorithm to Estimate Occupational (1→3)-β-D-glucan Exposure for Farmers in the Biomarkers of Exposure and Effect in Agriculture Study
Friesen MC, Hung F, Xie S, Viet SM, Deziel NC, Locke SJ, Josse PR, Sauvé JF, Andreotti G, Thorne PS, Beane-Freeman LE, Hofmann JN. A Task-Specific Algorithm to Estimate Occupational (1→3)-β-D-glucan Exposure for Farmers in the Biomarkers of Exposure and Effect in Agriculture Study. Annals Of Work Exposures And Health 2022, 66: 974-984. PMID: 35731645, PMCID: PMC9551320, DOI: 10.1093/annweh/wxac041.Peer-Reviewed Original ResearchAssessing Exposure to Unconventional Oil and Gas Development: Strengths, Challenges, and Implications for Epidemiologic Research
Deziel NC, Clark CJ, Casey JA, Bell ML, Plata DL, Saiers JE. Assessing Exposure to Unconventional Oil and Gas Development: Strengths, Challenges, and Implications for Epidemiologic Research. Current Environmental Health Reports 2022, 9: 436-450. PMID: 35522388, PMCID: PMC9363472, DOI: 10.1007/s40572-022-00358-4.Peer-Reviewed Original ResearchAssessing community-level exposure to social vulnerability and isolation: spatial patterning and urban-rural differences
Deziel NC, Warren JL, Bravo MA, Macalintal F, Kimbro RT, Bell ML. Assessing community-level exposure to social vulnerability and isolation: spatial patterning and urban-rural differences. Journal Of Exposure Science & Environmental Epidemiology 2022, 33: 198-206. PMID: 35388169, PMCID: PMC9535035, DOI: 10.1038/s41370-022-00435-8.Peer-Reviewed Original ResearchWhere Is Air Quality Improving, and Who Benefits? A Study of PM2.5 and Ozone Over 15 Years
Bravo MA, Warren JL, Leong MC, Deziel NC, Kimbro RT, Bell ML, Miranda ML. Where Is Air Quality Improving, and Who Benefits? A Study of PM2.5 and Ozone Over 15 Years. American Journal Of Epidemiology 2022, 191: 1258-1269. PMID: 35380633, PMCID: PMC9989362, DOI: 10.1093/aje/kwac059.Peer-Reviewed Original ResearchPrenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort
Luo J, Ramlau-Hansen CH, Kesmodel US, Xiao J, Vasiliou V, Deziel NC, Zhang Y, Olsen J, Liew Z. Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort. Environmental Health Perspectives 2022, 130: 017006. PMID: 35080464, PMCID: PMC8791068, DOI: 10.1289/ehp9478.Peer-Reviewed Original ResearchConceptsDanish National Birth CohortMaternal alcohol intakePrenatal PFAS exposurePalpebral fissure lengthShorter palpebral fissure lengthNational Birth CohortYears of agePFAS exposureSecond tertileAlcohol intakePrenatal exposureOdds ratioBirth cohortSpecific neurologic deficitsConfidence intervalsFetal brain developmentSex-specific associationsNeurologic deficitsFirst trimesterPotential confoundersNeurodevelopmental effectsAlcohol exposureStratified analysisNormal groupMultinomial logistic regressionObserved vs. self-reported agricultural activities: Evaluating 24-hr recall in a pilot study
Hung F, Hofmann JN, Josse PR, Locke SJ, Stapleton EM, Andreotti G, Deziel NC, Freeman L, Friesen MC. Observed vs. self-reported agricultural activities: Evaluating 24-hr recall in a pilot study. Journal Of Occupational And Environmental Hygiene 2022, 19: 87-90. PMID: 34895098, PMCID: PMC9756316, DOI: 10.1080/15459624.2021.2015074.Peer-Reviewed Original Research
2021
Invited Perspective: Oil and Gas Development and Adverse Birth Outcomes: What More Do We Need to Know?
Deziel NC. Invited Perspective: Oil and Gas Development and Adverse Birth Outcomes: What More Do We Need to Know? Environmental Health Perspectives 2021, 129: 071301. PMID: 34287014, PMCID: PMC8312483, DOI: 10.1289/ehp9715.Peer-Reviewed Original Research