Enhanced skin toxicity associated with the combination of clofarabine plus cytarabine for the treatment of acute leukemia
Zhang B, Bolognia J, Marks P, Podoltsev N. Enhanced skin toxicity associated with the combination of clofarabine plus cytarabine for the treatment of acute leukemia. Cancer Chemotherapy And Pharmacology 2014, 74: 303-307. PMID: 24908437, DOI: 10.1007/s00280-014-2504-y.Peer-Reviewed Original ResearchConceptsAcute leukemiaSkin toxicityCombination of clofarabineInitiation of chemotherapyPalmar-plantar erythrodysesthesiaCutaneous side effectsTwo-drug combinationsDifferent chemotherapeutic agentsCytarabine chemotherapyCytarabine groupResultsTen patientsCutaneous toxicityToxic erythemaCutaneous reactionsSkin findingsMedical recordsInstitutional experienceSevere formSide effectsPatientsBody foldsClofarabineChemotherapeutic agentsChemotherapyLeukemiaMarrow Assessment for Hemophagocytic Lymphohistiocytosis Demonstrates Poor Correlation With Disease Probability
Ho C, Yao X, Tian L, Li FY, Podoltsev N, Xu ML. Marrow Assessment for Hemophagocytic Lymphohistiocytosis Demonstrates Poor Correlation With Disease Probability. American Journal Of Clinical Pathology 2014, 141: 62-71. PMID: 24343738, DOI: 10.1309/ajcpmd5tjefoovbw.Peer-Reviewed Original ResearchConceptsFindings of hemophagocytosisHemophagocytic lymphohistiocytosisHistologic findingsProbability of HLHSecondary hemophagocytic lymphohistiocytosisCore biopsy specimenCore biopsy specimensDisease probabilityFisher's exact testElevated ferritinClinical suspicionMarrow assessmentHLH groupBiopsy specimenLaboratory criteriaBiopsy specimensMedical recordsHemophagocytosisExact testLymphohistiocytosisPatientsSignificant correlationAspiratesPoor correlationFindings