2024
Prolonged length of stay and omission of adjuvant therapy are associated with early mortality after pancreatic adenocarcinoma resection
Ying L, Ilagan-Ying Y, Kunstman J, Peters N, Almeida M, Blackburn H, Ferrucci L, Billingsley K, Khan S, Chhoda A, John N, Salem R, Sharma A, Ahuja N. Prolonged length of stay and omission of adjuvant therapy are associated with early mortality after pancreatic adenocarcinoma resection. Surgical Oncology Insight 2024, 1: 100007. DOI: 10.1016/j.soi.2024.100007.Peer-Reviewed Original ResearchFactors associated with early mortalityCases of pancreatic adenocarcinomaPancreatic adenocarcinoma resectionRisk of early mortalityLength of stayEarly mortalityAdjuvant chemotherapyPancreatic adenocarcinomaChemotherapy utilizationAdenocarcinoma resectionRisk factors associated with early mortalityOmission of adjuvant therapyNon-metastatic pancreatic adenocarcinomaMultivariate Cox regression modelAssociated with early mortalityPost-resection survivalIncreased risk of early mortalityParticipant Use FileProlonged hospital stayProlonged length of stayAdjuvant chemotherapy utilizationDecrease perioperative complicationsCox regression modelsNon-academic centersHospital risk factors
2018
Trends in Outcomes After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy
Gani F, Conca-Cheng AM, Nettles B, Ahuja N, Johnston FM. Trends in Outcomes After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. Journal Of Surgical Research 2018, 234: 240-248. PMID: 30527480, DOI: 10.1016/j.jss.2018.09.032.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinomaChemotherapy, Cancer, Regional PerfusionCombined Modality TherapyCytoreduction Surgical ProceduresDatabases, FactualFemaleHumansHyperthermia, InducedLogistic ModelsMaleMiddle AgedPatient SelectionPeritoneal NeoplasmsPostoperative ComplicationsRisk FactorsTreatment OutcomeConceptsCRS/HIPECHyperthermic intraperitoneal chemotherapyMedian operative timeLength of stayPostoperative morbidityCytoreductive surgeryOperative timeIntraperitoneal chemotherapySelect patientsClinical outcomesSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseCommon primary tumor siteQuality Improvement Program databaseMultivariable logistic regression analysisLow preoperative hematocritImprovement Program databasePreoperative serum albuminCareful patient selectionPrimary tumor siteLogistic regression analysisPostoperative complicationsPostoperative deathsPreoperative hematocritPeritoneal carcinomatosis
2014
Hospital Volume and Patient Outcomes in Hepato-Pancreatico-Biliary Surgery: Is Assessing Differences in Mortality Enough?
Schneider EB, Ejaz A, Spolverato G, Hirose K, Makary MA, Wolfgang CL, Ahuja N, Weiss M, Pawlik TM. Hospital Volume and Patient Outcomes in Hepato-Pancreatico-Biliary Surgery: Is Assessing Differences in Mortality Enough? Journal Of Gastrointestinal Surgery 2014, 18: 2105-2115. PMID: 25297443, DOI: 10.1007/s11605-014-2619-9.Peer-Reviewed Original ResearchConceptsLength of stayHV hospitalsHV centersHospital volumeMajor complicationsLV centersBiliary surgeryHPB surgeryHospital patientsShorter median LOSMedian LOSComplex HPB surgeryHospital volume strataIncidence of complicationsPost-operative complicationsOverall mean ageHepato-PancreaticoLV hospitalsMedical comorbiditiesImpact of regionalizationMean ageBiliary proceduresHemorrhagic anemiaPatient outcomesIndex mortalityRace-based differences in length of stay among patients undergoing pancreatoduodenectomy
Schneider EB, Calkins KL, Weiss MJ, Herman JM, Wolfgang CL, Makary MA, Ahuja N, Haider AH, Pawlik TM. Race-based differences in length of stay among patients undergoing pancreatoduodenectomy. Surgery 2014, 156: 528-537. PMID: 24973128, DOI: 10.1016/j.surg.2014.04.004.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlack or African AmericanCross-Sectional StudiesFemaleGeneral SurgeryHealthcare DisparitiesHispanic or LatinoHospital MortalityHospitalsHumansLength of StayLogistic ModelsMaleMiddle AgedPancreaticoduodenectomyPostoperative ComplicationsRacial GroupsRetrospective StudiesUnited StatesWhite PeopleConceptsHigh-volume hospitalsHigh-volume surgeonsHispanic patientsRace-based differencesWhite patientsMedian annual surgeon volumeAnnual hospital volumeAnnual surgeon volumeOverall median LOSNationwide Inpatient SampleMultivariable logistic regressionLength of stayHospital mortalityHospital lengthMedian LOSHospital volumeOperative morbidityProvider volumeSurgeon volumeMedian lengthPD patientsInpatient SamplePatient racePancreatoduodenectomyEligible individualsThe Impact of Postoperative Complications on the Administration of Adjuvant Therapy Following Pancreaticoduodenectomy for Adenocarcinoma
Wu W, He J, Cameron JL, Makary M, Soares K, Ahuja N, Rezaee N, Herman J, Zheng L, Laheru D, Choti MA, Hruban RH, Pawlik TM, Wolfgang CL, Weiss MJ. The Impact of Postoperative Complications on the Administration of Adjuvant Therapy Following Pancreaticoduodenectomy for Adenocarcinoma. Annals Of Surgical Oncology 2014, 21: 2873-2881. PMID: 24770680, PMCID: PMC4454347, DOI: 10.1245/s10434-014-3722-6.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantCombined Modality TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm StagingPancreatic NeoplasmsPancreaticoduodenectomyPostoperative ComplicationsPrognosisRadiotherapy, AdjuvantRetrospective StudiesSurvival RateConceptsAdjuvant therapyPostoperative complicationsMedian survivalMultivariate analysisClavien-Dindo complication gradeTherapy warrants further investigationMultimodality adjuvant therapyOverall complication rateMethodsA retrospective reviewGrade of complicationsLonger median survivalLength of stayWarrants further investigationAdjuvant chemotherapyMedian TTANeoadjuvant approachComplication gradeComplication rateSevere complicationsRetrospective reviewClinicopathological dataResultsA totalPancreaticoduodenectomyRadiation therapyComplicationsInpatient survival after gastrectomy for gastric cancer in the 21st century
Wang H, Pawlik TM, Duncan MD, Hui X, Selvarajah S, Canner JK, Haider AH, Ahuja N, Schneider EB. Inpatient survival after gastrectomy for gastric cancer in the 21st century. Journal Of Surgical Research 2014, 190: 72-78. PMID: 24725677, DOI: 10.1016/j.jss.2014.03.015.Peer-Reviewed Original ResearchConceptsLength of stayHospital-level factorsHospital mortalityGastric cancerNonelective admissionsLonger LOSBetter patient selectionNationwide Inpatient SampleMultivariable regression modelingRegionalization of careType of procedureInpatient survivalSurgery typeSurgical treatmentMultivariable analysisPatient selectionInpatient SamplePrimary diagnosisMale genderPrimary procedureProcedure typeTeaching hospitalLower oddsGastrectomyPatientsIs Minimally Invasive Colon Resection Better Than Traditional Approaches?: First Comprehensive National Examination With Propensity Score Matching
Juo YY, Hyder O, Haider AH, Camp M, Lidor A, Ahuja N. Is Minimally Invasive Colon Resection Better Than Traditional Approaches?: First Comprehensive National Examination With Propensity Score Matching. JAMA Surgery 2014, 149: 177-184. PMID: 24352653, PMCID: PMC4036435, DOI: 10.1001/jamasurg.2013.3660.Peer-Reviewed Original ResearchConceptsRoutine discharge ratesLaparoscopic colectomyOpen colectomyOstomy ratesColon resectionHospital mortalityComplication rateClinical outcomesUS Nationwide Inpatient Sample databaseNationwide Inpatient Sample databaseInvasive colon resectionPatients 21 yearsUS hospital dischargesShorter median lengthFavorable clinical outcomeLow complication rateLength of stayMost clinical outcomesOverall hospitalization costsLower mortality rateElective colectomyPerioperative outcomesDischarge dispositionHospital dischargeHospitalization costs
2010
Teaching Hospital Status and Operative Mortality in the United States: Tipping Point in the Volume-Outcome Relationship Following Colon Resections?
Hayanga AJ, Mukherjee D, Chang D, Kaiser H, Lee T, Gearhart S, Ahuja N, Freischlag J. Teaching Hospital Status and Operative Mortality in the United States: Tipping Point in the Volume-Outcome Relationship Following Colon Resections? JAMA Surgery 2010, 145: 346-350. PMID: 20404284, PMCID: PMC4036455, DOI: 10.1001/archsurg.2010.24.Peer-Reviewed Original ResearchConceptsNationwide Inpatient SampleLength of stayVolume-outcome relationshipColon resectionTeaching hospitalBenign diseaseOperative mortalityMean LOSColorectal surgery fellowshipsOdds of deathVolume-outcome effectRetrospective data analysisFederal poverty levelArea Resource FileComorbidity scoreSurgical resectionColon surgeryHospital covariatesNinth RevisionInpatient SampleInsurance statusPatient covariatesSurgeon characteristicsTH statusHospital status