2012
Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen
Jeschke J, Van Neste L, Glöckner SC, Dhir M, Calmon MF, Deregowski V, Van Criekinge W, Vlassenbroeck I, Koch A, Chan TA, Cope L, Hooker CM, Schuebel KE, Gabrielson E, Winterpacht A, Baylin SB, Herman JG, Ahuja N. Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen. Epigenetics 2012, 7: 701-709. PMID: 22647880, DOI: 10.4161/epi.20445.Peer-Reviewed Original ResearchConceptsPoor overall survivalBreast cancerOverall survivalPrognosis predictionEffective biomarkersClinical prognostic variablesPrimary breast cancerDetection of BCFrequent methylated genesStrongest single markersSignificant prognosticatorBC patientsValidation cohortPrognostic variablesPrognostic signatureEarly detectionCancerBiomarkersPromoter hypermethylationMethylation changesTumor heterogeneityPrognosisSingle markerGene expression approachSurvival
2011
Nurse-Perceived Barriers to Effective Communication Regarding Prognosis and Optimal End-of-Life Care for Surgical ICU Patients: A Qualitative Exploration (314-A)
Aslakson R, Wyskiel R, Thornton I, Copley C, Shaffer D, Zyra M, Ahuja N, Nelson J, Pronovost P. Nurse-Perceived Barriers to Effective Communication Regarding Prognosis and Optimal End-of-Life Care for Surgical ICU Patients: A Qualitative Exploration (314-A). Journal Of Pain And Symptom Management 2011, 41: 193. DOI: 10.1016/j.jpainsymman.2010.10.051.Peer-Reviewed Original Research
2010
Surgical intensive care unit clinician estimates of the adequacy of communication regarding patient prognosis
Aslakson RA, Wyskiel R, Shaeffer D, Zyra M, Ahuja N, Nelson JE, Pronovost PJ. Surgical intensive care unit clinician estimates of the adequacy of communication regarding patient prognosis. Critical Care 2010, 14: r218. PMID: 21114837, PMCID: PMC3220002, DOI: 10.1186/cc9346.Peer-Reviewed Original ResearchConceptsICU physiciansICU nursesNurse practitionersSurgical ICUPatient prognosisAdequacy of communicationHealth care providers' opinionsHigh-quality ICU careHigh satisfactionCare providers' opinionsCare unit patientsHealth care providersFamily members' perspectivesLower satisfactionICU careUnit patientsFurther validation studiesClinicians' estimatesClinicians' perceptionsPractice guidelinesProviders' opinionsNurse communicationCare providersPatient's familyPrognosis