2016
Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma
Poruk KE, Valero V, Saunders T, Blackford AL, Griffin JF, Poling J, Hruban RH, Anders RA, Herman J, Zheng L, Rasheed ZA, Laheru DA, Ahuja N, Weiss MJ, Cameron JL, Goggins M, Iacobuzio-Donahue CA, Wood LD, Wolfgang CL. Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma. Annals Of Surgery 2016, 264: 1073-1081. PMID: 26756760, PMCID: PMC4936958, DOI: 10.1097/sla.0000000000001600.Peer-Reviewed Original ResearchConceptsCytokeratin-positive CTCsPancreatic adenocarcinomaMesenchymal markersVimentin-positive CTCsEpithelial tumor cells (ISET) methodFourth leading causeBetter treatment stratificationPortal blood samplesSignificant independent predictorsPotential prognostic biomarkerBiology of metastasisDetection of CTCsSurgical resectionIndependent predictorsPrognostic factorsMedian timeMultivariable analysisPDAC patientsPrognostic utilityCancer deathPatient prognosisLeading causeTreatment stratificationCancer recurrencePoor survival
2015
Early hospital readmission for gastrointestinal-related complications predicts long-term mortality after pancreatectomy
Hicks CW, Tosoian JJ, Craig-Schapiro R, Valero V, Cameron JL, Eckhauser FE, Hirose K, Makary MA, Pawlik TM, Ahuja N, Weiss MJ, Wolfgang CL. Early hospital readmission for gastrointestinal-related complications predicts long-term mortality after pancreatectomy. The American Journal Of Surgery 2015, 210: 636-642.e1. PMID: 26384793, PMCID: PMC4634566, DOI: 10.1016/j.amjsurg.2015.05.009.Peer-Reviewed Original ResearchConceptsEarly hospital readmissionHospital readmissionOverall mortalityLong-term mortalitySignificant independent predictorsBaseline group differencesPancreatectomy patientsIndependent predictorsPrognostic significanceInstitutional databaseRisk factorsPancreatectomyMultivariate analysisReadmissionMortalityComplicationsPatientsAdditional studiesGroup differencesStatewide datasetMorbiditySocial factors