2019
Operative Mortality Prediction for Primary Rectal Cancer: Age Matters
Li Z, Coleman J, D'Adamo CR, Wolf J, Katlic M, Ahuja N, Blumberg D, Ahuja V. Operative Mortality Prediction for Primary Rectal Cancer: Age Matters. Journal Of The American College Of Surgeons 2019, 228: 627-633. PMID: 30630082, DOI: 10.1016/j.jamcollsurg.2018.12.014.Peer-Reviewed Original ResearchConceptsPrimary rectal cancerRectal cancerLogistic regression modelsActual mortalityOlder patientsRisk calculatorAmerican CollegeCovariate-adjusted logistic regression modelsCurrent risk calculatorsICD-9/10 codesColorectal cancer increasesSurgeons NSQIP databaseYears age groupAge categoriesMortality risk estimatesOperative mortalityNSQIP databaseRegression modelsPrognostic valueFunctional statusCancer increasesCare discussionsMortality predictionCPT codesAge groups
2018
Trends in Outcomes After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy
Gani F, Conca-Cheng AM, Nettles B, Ahuja N, Johnston FM. Trends in Outcomes After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. Journal Of Surgical Research 2018, 234: 240-248. PMID: 30527480, DOI: 10.1016/j.jss.2018.09.032.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinomaChemotherapy, Cancer, Regional PerfusionCombined Modality TherapyCytoreduction Surgical ProceduresDatabases, FactualFemaleHumansHyperthermia, InducedLogistic ModelsMaleMiddle AgedPatient SelectionPeritoneal NeoplasmsPostoperative ComplicationsRisk FactorsTreatment OutcomeConceptsCRS/HIPECHyperthermic intraperitoneal chemotherapyMedian operative timeLength of stayPostoperative morbidityCytoreductive surgeryOperative timeIntraperitoneal chemotherapySelect patientsClinical outcomesSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseCommon primary tumor siteQuality Improvement Program databaseMultivariable logistic regression analysisLow preoperative hematocritImprovement Program databasePreoperative serum albuminCareful patient selectionPrimary tumor siteLogistic regression analysisPostoperative complicationsPostoperative deathsPreoperative hematocritPeritoneal carcinomatosis
2017
Can echogenic appearance of neuroendocrine liver metastases on intraoperative ultrasonography predict tumor biology and prognosis?
Dogeas E, Chong CCN, Weiss MJ, Ahuja N, Choti MA. Can echogenic appearance of neuroendocrine liver metastases on intraoperative ultrasonography predict tumor biology and prognosis? Hepato Pancreato Biliary 2017, 20: 237-243. PMID: 29103839, DOI: 10.1016/j.hpb.2017.08.029.Peer-Reviewed Original ResearchConceptsNeuroendocrine liver metastasesTumor biologyLiver metastasesShorter median disease-free survivalMedian disease-free survivalDisease-free survivalManagement of patientsPotential prognostic factorsSmaller tumor sizeLong-term outcomesHypoechoic metastasesAdditional metastasesPrognostic factorsClinicopathologic factorsSurgical interventionSurgical strategyPreoperative imagingTumor sizeHypoechoic lesionsIntraoperative ultrasonographyNeuroendocrine tumorsProspective dataHyperechoic lesionsTumor gradeBiologic behavior
2015
Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinoma
Rezaee N, Barbon C, Zaki A, He J, Salman B, Hruban RH, Cameron JL, Herman JM, Ahuja N, Lennon AM, Weiss MJ, Wood LD, Wolfgang CL. Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinoma. Hepato Pancreato Biliary 2015, 18: 236-246. PMID: 27017163, PMCID: PMC4814593, DOI: 10.1016/j.hpb.2015.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Pancreatic DuctalDatabases, FactualDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedNeoplasm GradingNeoplasm InvasivenessNeoplasms, Cystic, Mucinous, and SerousNeoplasms, Second PrimaryPancreatectomyPancreatic NeoplasmsProportional Hazards ModelsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsIntraductal papillary mucinous neoplasmHigh-grade dysplasiaPancreatic ductal adenocarcinomaNon-invasive intraductal papillary mucinous neoplasmsIntermediate-grade dysplasiaPapillary mucinous neoplasmRemnant pancreasVascular invasionMucinous neoplasmsDuctal adenocarcinomaInvasive pancreatic ductal adenocarcinomaMedian overall survivalLymph node metastasisRate of progressionSubsequent developmentIntermediate dysplasiaPancreatic resectionOverall survivalNode metastasisPerineural invasionMalignant entitiesRisk factorsPatientsDysplasiaPancreasSurvival Following Lung Metastasectomy in Soft Tissue Sarcomas
Giuliano K, Sachs T, Montgomery E, Guzzetta A, Brock M, Pawlik TM, Yang SC, Ahuja N. Survival Following Lung Metastasectomy in Soft Tissue Sarcomas. The Thoracic And Cardiovascular Surgeon 2015, 64: 150-158. PMID: 26339728, DOI: 10.1055/s-0035-1563538.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overChildChild, PreschoolDisease-Free SurvivalFemaleHumansInfantKaplan-Meier EstimateLung NeoplasmsMaleMetastasectomyMiddle AgedNeoplasm GradingPneumonectomyRetrospective StudiesRisk FactorsSarcomaSoft Tissue NeoplasmsThoracoscopyTime FactorsTreatment OutcomeYoung AdultConceptsDisease-free intervalSoft tissue sarcomasLung metastasectomyTissue sarcomasLonger disease-free intervalLower pathologic gradeMedian overall survivalKaplan-Meier estimatesLog-rank testLow-grade tumorsGreatest survival advantageOverall survivalPostoperative factorsImproved survivalPatient selectionTumor characteristicsPathologic gradeMetastasis diagnosisCommon siteSurvival advantageSurvival analysisYounger ageMetastasectomyPatientsSurvivalPromoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival Outcome
Deckers IA, Schouten LJ, Van Neste L, van Vlodrop IJ, Soetekouw PM, Baldewijns MM, Jeschke J, Ahuja N, Herman JG, van den Brandt PA, van Engeland M. Promoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival Outcome. Clinical Cancer Research 2015, 21: 3492-3500. PMID: 25904753, PMCID: PMC4612631, DOI: 10.1158/1078-0432.ccr-14-2049.Peer-Reviewed Original ResearchConceptsCDO1 promoter methylationNetherlands Cohort StudyCysteine dioxygenase type 1Prognostic markerPromoter methylationCcRCC casesRenal cell cancer patientsProspective Netherlands Cohort StudyMultivariate modelRelative prognostic valueKaplan-Meier curvesPopulation-based seriesClear cell renal cell cancer (ccRCC) patientsCurrent prognostic markersPoor survival outcomesConfidence intervalsRelevant prognostic informationIndividual patient outcomesMultivariate HRCohort studyMethylation-specific PCR analysisCancer Genome AtlasPrognostic factorsPrognostic valuePromoter methylation statusEarly hospital readmission for gastrointestinal-related complications predicts long-term mortality after pancreatectomy
Hicks CW, Tosoian JJ, Craig-Schapiro R, Valero V, Cameron JL, Eckhauser FE, Hirose K, Makary MA, Pawlik TM, Ahuja N, Weiss MJ, Wolfgang CL. Early hospital readmission for gastrointestinal-related complications predicts long-term mortality after pancreatectomy. The American Journal Of Surgery 2015, 210: 636-642.e1. PMID: 26384793, PMCID: PMC4634566, DOI: 10.1016/j.amjsurg.2015.05.009.Peer-Reviewed Original ResearchConceptsEarly hospital readmissionHospital readmissionOverall mortalityLong-term mortalitySignificant independent predictorsBaseline group differencesPancreatectomy patientsIndependent predictorsPrognostic significanceInstitutional databaseRisk factorsPancreatectomyMultivariate analysisReadmissionMortalityComplicationsPatientsAdditional studiesGroup differencesStatewide datasetMorbiditySocial factorsTracking Early Readmission After Pancreatectomy to Index and Nonindex Institutions: A More Accurate Assessment of Readmission
Tosoian JJ, Hicks CW, Cameron JL, Valero V, Eckhauser FE, Hirose K, Makary MA, Pawlik TM, Ahuja N, Weiss MJ, Wolfgang CL. Tracking Early Readmission After Pancreatectomy to Index and Nonindex Institutions: A More Accurate Assessment of Readmission. JAMA Surgery 2015, 150: 152-158. PMID: 25535811, PMCID: PMC4461067, DOI: 10.1001/jamasurg.2014.2346.Peer-Reviewed Original ResearchConceptsTertiary care referral centerPatient-level factorsNonindex hospitalEarly readmissionReferral centerMultivariable analysisPatterns of readmissionPostoperative drain placementRate of readmissionRisk of readmissionData of patientsAge 65 yearsHigh-volume institutionsDistal pancreatectomyPostoperative infectionPrimary outcomeLiver diseaseDrain placementInstitutional databaseRisk factorsPancreatectomyRetrospective analysisReadmissionMAIN OUTCOMEPatients
2014
Hospital Volume and Patient Outcomes in Hepato-Pancreatico-Biliary Surgery: Is Assessing Differences in Mortality Enough?
Schneider EB, Ejaz A, Spolverato G, Hirose K, Makary MA, Wolfgang CL, Ahuja N, Weiss M, Pawlik TM. Hospital Volume and Patient Outcomes in Hepato-Pancreatico-Biliary Surgery: Is Assessing Differences in Mortality Enough? Journal Of Gastrointestinal Surgery 2014, 18: 2105-2115. PMID: 25297443, DOI: 10.1007/s11605-014-2619-9.Peer-Reviewed Original ResearchConceptsLength of stayHV hospitalsHV centersHospital volumeMajor complicationsLV centersBiliary surgeryHPB surgeryHospital patientsShorter median LOSMedian LOSComplex HPB surgeryHospital volume strataIncidence of complicationsPost-operative complicationsOverall mean ageHepato-PancreaticoLV hospitalsMedical comorbiditiesImpact of regionalizationMean ageBiliary proceduresHemorrhagic anemiaPatient outcomesIndex mortality
2013
Trends and Risk Factors for Transfusion in Hepatopancreatobiliary Surgery
Lucas DJ, Schexneider KI, Weiss M, Wolfgang CL, Frank SM, Hirose K, Ahuja N, Makary M, Cameron JL, Pawlik TM. Trends and Risk Factors for Transfusion in Hepatopancreatobiliary Surgery. Journal Of Gastrointestinal Surgery 2013, 18: 719-728. PMID: 24323432, DOI: 10.1007/s11605-013-2417-9.Peer-Reviewed Original ResearchConceptsRisk of transfusionRisk factorsPerioperative transfusionPreoperative hematocritBlood transfusionHPB proceduresPublic Use FilePatient-level risk factorsAnesthesiologists class IVIncidence of transfusionPerioperative blood transfusionPatient-level factorsHigh-risk factorsPatient-specific factorsHepatopancreatobiliary proceduresTransfusion utilizationPreoperative albuminTransfusion rateASA classificationPancreatic resectionHPB surgeryHepatopancreatobiliary surgeryProcedure typeInclusion criteriaTransfusionAssessing Readmission After General, Vascular, and Thoracic Surgery Using ACS-NSQIP
Lucas DJ, Haider A, Haut E, Dodson R, Wolfgang CL, Ahuja N, Sweeney J, Pawlik TM. Assessing Readmission After General, Vascular, and Thoracic Surgery Using ACS-NSQIP. Annals Of Surgery 2013, 258: 430-439. PMID: 24022435, PMCID: PMC4623433, DOI: 10.1097/sla.0b013e3182a18fcc.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDatabases, FactualDecision Support TechniquesFemaleFollow-Up StudiesHealth Status IndicatorsHumansLength of StayMaleMiddle AgedMultivariate AnalysisPatient ReadmissionPostoperative ComplicationsRegression AnalysisRisk FactorsROC CurveSurgical Procedures, OperativeThoracic Surgical ProceduresUnited StatesVascular Surgical ProceduresConceptsASA classReadmission ratesThoracic surgerySurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramInteger-based scoreMedian American SocietyStay 10 daysMedian patient ageRisk of readmissionHigher readmission ratesQuality Improvement ProgramAnesthesiologists classInpatient complicationsMedian LOSPatient agePatient characteristicsNonelective surgeryUpper gastrointestinalACS-NSQIPReadmission riskRisk factorsReadmissionAmerican College2564 resected periampullary adenocarcinomas at a single institution: trends over three decades
He J, Ahuja N, Makary MA, Cameron JL, Eckhauser FE, Choti MA, Hruban RH, Pawlik TM, Wolfgang CL. 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades. Hepato Pancreato Biliary 2013, 16: 83-90. PMID: 23472829, PMCID: PMC3892319, DOI: 10.1111/hpb.12078.Peer-Reviewed Original ResearchConceptsPeriampullary adenocarcinomaBile ductSingle institutionPancreatic cancerIntraductal papillary mucinous neoplasmNumber of patientsPapillary mucinous neoplasmRelative survival ratesCurative intentWorse survivalLongterm outcomesMucinous neoplasmsSafe resectionLongterm survivalPathological diagnosisPrimary siteSurvival ratePancreaticoduodenectomyAdenocarcinomaPatientsSurvivalResectionSignificant differencesCancerDiagnosis
2011
Predicting the Risk of Perioperative Mortality in Patients Undergoing Pancreaticoduodenectomy: A Novel Scoring System
Venkat R, Puhan MA, Schulick RD, Cameron JL, Eckhauser FE, Choti MA, Makary MA, Pawlik TM, Ahuja N, Edil BH, Wolfgang CL. Predicting the Risk of Perioperative Mortality in Patients Undergoing Pancreaticoduodenectomy: A Novel Scoring System. JAMA Surgery 2011, 146: 1277-1284. PMID: 22106320, DOI: 10.1001/archsurg.2011.294.Peer-Reviewed Original ResearchConceptsTotal pancreatectomyCharlson indexInstitutional databaseRisk scorePreoperative serum albumin levelHigher Charlson indexPreoperative risk factorsHigh-risk patientsSerum albumin levelTertiary referral centerMultivariate logistic regressionHosmer-Lemeshow testNovel scoring systemSimple integer scoreHigh-volume programPerioperative mortalityReferral centerAlbumin levelsMale sexTumor sizeTraining cohortRisk factorsTherapeutic decisionsObservational studyPancreatectomy
2010
Asian Race/Ethnicity as a Risk Factor for Bile Duct Injury During Cholecystectomy
Downing SR, Datoo G, Oyetunji TA, Fullum T, Chang DC, Ahuja N. Asian Race/Ethnicity as a Risk Factor for Bile Duct Injury During Cholecystectomy. JAMA Surgery 2010, 145: 785-787. PMID: 20713933, PMCID: PMC4086633, DOI: 10.1001/archsurg.2010.131.Peer-Reviewed Original ResearchConceptsBile duct injuryAsian race/ethnicityRace/ethnicitySignificant risk factorsRisk factorsDuct injuryIatrogenic bile duct injuryMultivariate logistic regression analysisAberrant biliary anatomyHospital days 0Nationwide Inpatient SampleLogistic regression analysisAcute cholecystitisOpen cholecystectomySerious complicationsMale sexBiliary anatomyInpatient SampleCholecystectomyDay 0Older ageLaparoscopicRegression analysisInjuryProcedure codes
2009
Predictors of Survival After Resection of Retroperitoneal Sarcoma
Nathan H, Raut CP, Thornton K, Herman JM, Ahuja N, Schulick RD, Choti MA, Pawlik TM. Predictors of Survival After Resection of Retroperitoneal Sarcoma. Annals Of Surgery 2009, 250: 970-976. PMID: 19644351, PMCID: PMC3099434, DOI: 10.1097/sla.0b013e3181b25183.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleFollow-Up StudiesHumansInfantInfant, NewbornKaplan-Meier EstimateMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPostoperative PeriodPrognosisProportional Hazards ModelsRetroperitoneal NeoplasmsRetrospective StudiesRisk FactorsSarcomaSEER ProgramSurvival RateTime FactorsUnited StatesYoung AdultConceptsPrimary retroperitoneal sarcomaRetroperitoneal sarcomaPredictors of survivalAJCC staging systemTumor sizeStaging systemRPS resectionHistological subtypesCurrent AJCC staging systemPatients Undergoing ResectionDiscriminatory abilityEnd Results (SEER) databaseAmerican Joint CommitteeCancer (AJCC) staging systemLymph node metastasisModerate discriminatory abilityMalignant fibrous histiocytomaProportional hazards modelPoor discriminatory abilityPrevalent histologyUndergoing resectionNode metastasisAJCC stageMultivariable analysisResults database
2008
Multilevel Analysis of the Impact of Community vs Patient Factors on Access to Immediate Breast Reconstruction Following Mastectomy in Maryland
Rosson GD, Singh NK, Ahuja N, Jacobs LK, Chang DC. Multilevel Analysis of the Impact of Community vs Patient Factors on Access to Immediate Breast Reconstruction Following Mastectomy in Maryland. JAMA Surgery 2008, 143: 1076-1081. PMID: 19015466, DOI: 10.1001/archsurg.143.11.1076.Peer-Reviewed Original ResearchConceptsRace/ethnicityImmediate reconstructionPatient factorsPatient's neighborhoodMaryland hospital discharge databasePatient race/ethnicityAfrican American race/ethnicityBreast Reconstruction Following MastectomyImmediate reconstruction ratesNinth Revision procedureImmediate breast reconstructionHospital discharge databaseCommunity factorsCommunity-level factorsPublic health policy measuresSame hospitalizationPatient characteristicsPatient demographicsHealth policy measuresNegative associationDischarge databaseFollowing MastectomyBreast reconstructionInpatient careRevision procedures
2002
DNA Methylation and Environmental Exposures in Human Hepatocellular Carcinoma
Shen L, Ahuja N, Shen Y, Habib NA, Toyota M, Rashid A, Issa JP. DNA Methylation and Environmental Exposures in Human Hepatocellular Carcinoma. Journal Of The National Cancer Institute 2002, 94: 755-761. PMID: 12011226, DOI: 10.1093/jnci/94.10.755.Peer-Reviewed Original Research