2018
A novel epigenetic modulating agent sensitizes pancreatic cells to a chemotherapy agent
Thakar M, Hu Y, Morreale M, Lerner L, Lin W, Sen R, Cai Y, Karunasena E, Thakar M, Saggi S, Keer H, Ahuja N. A novel epigenetic modulating agent sensitizes pancreatic cells to a chemotherapy agent. PLOS ONE 2018, 13: e0199130. PMID: 29927979, PMCID: PMC6013229, DOI: 10.1371/journal.pone.0199130.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaDNA methyltransferase 1Chemotherapeutic agent irinotecanEpigenetic modulating agentsPDAC cell linesCell viabilityMechanism of actionSystemic chemotherapyCancer mortalityChemotherapy responseDuctal adenocarcinomaChemotherapy agentsEpigenetic sensitizationModulating agentsGuadecitabineAdditional studiesPancreatic cellsSerial concentrationsRest periodCell linesNanomolar concentrationsImproved responseEpigenetic modulatorsSensitizationMethyltransferase 1
2015
A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts
Springer S, Wang Y, Dal Molin M, Masica DL, Jiao Y, Kinde I, Blackford A, Raman SP, Wolfgang CL, Tomita T, Niknafs N, Douville C, Ptak J, Dobbyn L, Allen PJ, Klimstra DS, Schattner MA, Schmidt CM, Yip-Schneider M, Cummings OW, Brand RE, Zeh HJ, Singhi AD, Scarpa A, Salvia R, Malleo G, Zamboni G, Falconi M, Jang JY, Kim SW, Kwon W, Hong SM, Song KB, Kim SC, Swan N, Murphy J, Geoghegan J, Brugge W, Castillo C, Mino-Kenudson M, Schulick R, Edil BH, Adsay V, Paulino J, van Hooft J, Yachida S, Nara S, Hiraoka N, Yamao K, Hijioka S, van der Merwe S, Goggins M, Canto MI, Ahuja N, Hirose K, Makary M, Weiss MJ, Cameron J, Pittman M, Eshleman JR, Diaz LA, Papadopoulos N, Kinzler KW, Karchin R, Hruban RH, Vogelstein B, Lennon AM. A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts. Gastroenterology 2015, 149: 1501-1510. PMID: 26253305, PMCID: PMC4782782, DOI: 10.1053/j.gastro.2015.07.041.Peer-Reviewed Original Research
2014
A comparison of open and minimally invasive surgery for hepatic and pancreatic resections using the nationwide inpatient sample
Ejaz A, Sachs T, He J, Spolverato G, Hirose K, Ahuja N, Wolfgang CL, Makary MA, Weiss M, Pawlik TM. A comparison of open and minimally invasive surgery for hepatic and pancreatic resections using the nationwide inpatient sample. Surgery 2014, 156: 538-547. PMID: 25017135, PMCID: PMC4316739, DOI: 10.1016/j.surg.2014.03.046.Peer-Reviewed Original ResearchConceptsMIS patientsInpatient outcomesLiver operationsNationwide Inpatient Sample databasePreoperative medical comorbiditiesIncidence of complicationsMultiple comorbid conditionsShorter median lengthAppropriate International ClassificationNationwide Inpatient SampleInvasive surgery techniquesDuration of stayHospital mortalityPostoperative morbidityHepatic resectionMedical comorbiditiesPancreatic resectionComorbid conditionsMIS groupMedian lengthOpen surgeryInpatient SampleOpen procedureRobotic assistInternational ClassificationAssessing the experience in complex hepatopancreatobiliary surgery among graduating chief residents: Is the operative experience enough?
Sachs TE, Ejaz A, Weiss M, Spolverato G, Ahuja N, Makary MA, Wolfgang CL, Hirose K, Pawlik TM. Assessing the experience in complex hepatopancreatobiliary surgery among graduating chief residents: Is the operative experience enough? Surgery 2014, 156: 385-393. PMID: 24953270, PMCID: PMC4316664, DOI: 10.1016/j.surg.2014.03.006.Peer-Reviewed Original ResearchConceptsMedian numberBiliary tractHPB casesHepatopancreatobiliary surgeryCase volumeMean numberPancreas casesChief yearChief residentsAccreditation CouncilGeneral surgery residentsHPB operationsMajor resectionAnatomic resectionSimple cholecystectomyPancreatic operationsPostgraduate year 1TA casesComplex liverPancreasOperative experienceResident operative autonomyLiverSame time periodSurgery residents