Featured Publications
Interspecies commensal interactions have nonlinear impacts on host immunity
Rice TA, Bielecka AA, Nguyen MT, Rosen CE, Song D, Sonnert ND, Yang Y, Cao Y, Khetrapal V, Catanzaro JR, Martin AL, Rashed SA, Leopold SR, Hao L, Yu X, van Dijk D, Ring AM, Flavell RA, de Zoete MR, Palm NW. Interspecies commensal interactions have nonlinear impacts on host immunity. Cell Host & Microbe 2022, 30: 988-1002.e6. PMID: 35640610, PMCID: PMC9283318, DOI: 10.1016/j.chom.2022.05.004.Peer-Reviewed Original ResearchConceptsImmunological outcomesCell activationIntestinal epithelial cell activationInflammatory bowel disease patientsBowel disease patientsDendritic cell activationMesenteric lymph nodesSystemic antibody responsesEpithelial cell activationImmunological milieuLymph nodesAntibody responseDisease patientsAkkermansia muciniphilaGnotobiotic miceHost immunityCommensal microbesHuman cohortsHuman gut bacteriaGut bacteriaMiceAllobaculumMuciniphilaDiseaseIncomplete penetrance
2013
Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective Immunity
Palm NW, Rosenstein RK, Yu S, Schenten DD, Florsheim E, Medzhitov R. Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective Immunity. Immunity 2013, 39: 976-985. PMID: 24210353, PMCID: PMC3852615, DOI: 10.1016/j.immuni.2013.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAnaphylaxisAnimalsBee VenomsCrotalid VenomsGenes, ReporterImmunity, InnateImmunoglobulin EImmunoglobulin GInsect ProteinsInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Interleukin-4InterleukinsLymphocyte ActivationLysophospholipidsMelittenMembrane LipidsMiceMice, Inbred BALB CMice, KnockoutMyeloid Differentiation Factor 88OvalbuminPhospholipases A2PhospholipidsReceptors, IgEReceptors, InterleukinTh2 CellsConceptsInnate immune systemBee venom phospholipase A2Components of venomPhospholipase A2Immune responseGroup 2 Innate Lymphoid Cell ActivationVenom phospholipase A2Immune systemInnate lymphoid cell activationType 2 immune responsesLymphoid cell activationType 2 responsesProtective immune responseConfer protective immunityIgE responseInterleukin-33Receptor ST2Protective immunityCell type responsesCell activationLethal doseMajor allergenBee venomAllergensVenom toxins