2019
Early alterations in stem-like/resident T cells, innate and myeloid cells in the bone marrow in preneoplastic gammopathy
Bailur JK, McCachren SS, Doxie DB, Shrestha M, Pendleton K, Nooka AK, Neparidze N, Parker TL, Bar N, Kaufman JL, Hofmeister CC, Boise LH, Lonial S, Kemp ML, Dhodapkar KM, Dhodapkar MV. Early alterations in stem-like/resident T cells, innate and myeloid cells in the bone marrow in preneoplastic gammopathy. JCI Insight 2019, 5 PMID: 31013254, PMCID: PMC6629164, DOI: 10.1172/jci.insight.127807.Peer-Reviewed Original ResearchMeSH KeywordsBone MarrowCell Transformation, NeoplasticFemaleGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 1-alphaHumansImmunity, InnateImmunologic MemoryImmunologic SurveillanceIntercellular Signaling Peptides and ProteinsMaleMiddle AgedMonoclonal Gammopathy of Undetermined SignificanceMultiple MyelomaMyeloid CellsPrecancerous ConditionsRNA-SeqSingle-Cell AnalysisStem CellsT-LymphocytesTumor MicroenvironmentConceptsMemory T cellsSingle-cell transcriptome analysisT cellsMyeloid cellsMyeloma patientsTerminal effector differentiationImmune cellsHealthy donorsProlonged dormancyTranscriptome analysisBone marrowBone marrow immune cellsStem-like cellsStem-like T cellsAge-matched healthy donorsDistinct genomic profilesResident T cellsSingle immune cellsT cell compartmentBone marrow plasmaCell compartmentGenomic profilesCancer cellsPreneoplastic gammopathyImmune microenvironment
2016
Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells
Boddupalli CS, Bar N, Kadaveru K, Krauthammer M, Pornputtapong N, Mai Z, Ariyan S, Narayan D, Kluger H, Deng Y, Verma R, Das R, Bacchiocchi A, Halaban R, Sznol M, Dhodapkar MV, Dhodapkar KM. Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells. JCI Insight 2016, 1: e88955. PMID: 28018970, PMCID: PMC5161225, DOI: 10.1172/jci.insight.88955.Peer-Reviewed Original ResearchTumor-infiltrating lymphocytesMemory T cellsTissue-resident memory T cellsT cell receptorImmune checkpointsT cellsIndividual metastasesSubset of TILsExpression of ICsCell receptorTumor cellsLess IL-2Blood T cellsExpression of VEGFTIL infiltrationDurable responsesAdvanced melanomaImmune therapyNeoantigen loadIL-2Immune cellsNonlymphoid tissuesSame patientMyeloid cellsMetastasis
2015
Tissue resident memory T cells create genetically distinct immune microenvironments within melanoma metastasis
Dhodapkar K, Bar N, Boddupalli C, Kadaveru K, Mai Z, Deng Y, Sznol M, Dhodapkar M. Tissue resident memory T cells create genetically distinct immune microenvironments within melanoma metastasis. Journal For ImmunoTherapy Of Cancer 2015, 3: o15. PMCID: PMC4645446, DOI: 10.1186/2051-1426-3-s2-o15.Peer-Reviewed Original Research