2010
Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
Boiko A, Razorenova O, van de Rijn M, Swetter S, Johnson D, Ly D, Butler P, Yang G, Joshua B, Kaplan M, Longaker M, Weissman I. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature 2010, 466: 133-137. PMID: 20596026, PMCID: PMC2898751, DOI: 10.1038/nature09161.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, NeoplasmBone and BonesBone TransplantationDNA-Binding ProteinsHumansLung NeoplasmsMelanomaMelanoma-Specific AntigensMiceMice, KnockoutNeoplasm MetastasisNeoplasm ProteinsNeoplasm TransplantationNeoplastic Stem CellsNerve Tissue ProteinsNeural CrestReceptors, Nerve Growth FactorSkinSkin TransplantationTransplantation, Heterologous
2009
Unfolded Protein Response Regulation in Keloid Cells
Butler PD, Wang Z, Ly DP, Longaker MT, Koong AC, Yang GP. Unfolded Protein Response Regulation in Keloid Cells. Journal Of Surgical Research 2009, 167: 151-157. PMID: 19631342, PMCID: PMC2888625, DOI: 10.1016/j.jss.2009.04.036.Peer-Reviewed Original ResearchConceptsUnfolded protein responsePancreatic ER kinaseXBP-1 proteinNuclear localizationXBP-1Keloid fibroblastsNormal fibroblastsExtracellular matrixXBP-1 splicingUPR transducersSpecific molecular defectsPathologic wound healingUPR responseUPR activationProtein responseER kinaseCellular responsesMolecular defectsATF-6Keloid cellsResponse regulationProteinWound healing therapyWound microenvironmentActivation