2009
Unfolded Protein Response Regulation in Keloid Cells
Butler PD, Wang Z, Ly DP, Longaker MT, Koong AC, Yang GP. Unfolded Protein Response Regulation in Keloid Cells. Journal Of Surgical Research 2009, 167: 151-157. PMID: 19631342, PMCID: PMC2888625, DOI: 10.1016/j.jss.2009.04.036.Peer-Reviewed Original ResearchConceptsUnfolded protein responsePancreatic ER kinaseXBP-1 proteinNuclear localizationXBP-1Keloid fibroblastsNormal fibroblastsExtracellular matrixXBP-1 splicingUPR transducersSpecific molecular defectsPathologic wound healingUPR responseUPR activationProtein responseER kinaseCellular responsesMolecular defectsATF-6Keloid cellsResponse regulationProteinWound healing therapyWound microenvironmentActivation
2008
Use of organotypic coculture to study keloid biology
Butler PD, Ly DP, Longaker MT, Yang GP. Use of organotypic coculture to study keloid biology. The American Journal Of Surgery 2008, 195: 144-148. PMID: 18070722, PMCID: PMC2245861, DOI: 10.1016/j.amjsurg.2007.10.003.Peer-Reviewed Original ResearchConceptsNormal human keratinocytesAnimal modelsKeloid formationOrganotypic skinKeloid biologyDermal contracturesDefinitive therapyFetal calf serumOrganotypic skin modelsCollagen depositionDermal thicknessMuscle actinOrganotypic skin culturesSkin culturesCollagen stainingPathologic scarsOrganotypic coculturesCollagen productionHuman keratinocytesSkinContractureCalf serumDermal layerDermal structuresEagle's medium