2004
The Role of Bisphosphonates in the Treatment of Skeletal Complications of Breast Cancer
El-Rayes B, LoRusso P. The Role of Bisphosphonates in the Treatment of Skeletal Complications of Breast Cancer. American Journal Of Cancer 2004, 3: 369-375. DOI: 10.2165/00024669-200403060-00004.Peer-Reviewed Original ResearchBreast cancerZoledronic acidPamidronic acidIbandronic acidPlacebo-controlled trialSerum creatinine levelsSpinal cord compressionLarge randomized studiesMetastatic breast cancerRole of bisphosphonatesBreast cancer patientsClodronic acidClass of agentsCord compressionGastrointestinal symptomsRenal impairmentSkeletal complicationsSkeletal eventsCreatinine levelsMajor toxicityBone destructionBone metastasesRadiographic evidenceRandomized studySignificant morbidity
2001
Analysis of skeletal-related events in breast cancer and response to therapy
LoRusso P. Analysis of skeletal-related events in breast cancer and response to therapy. Seminars In Oncology 2001, 28: 22-27. PMID: 11544572, DOI: 10.1016/s0093-7754(01)90228-3.Peer-Reviewed Original ResearchConceptsBone metastasesSkeletal morbiditySkeletal complicationsSkeletal related eventsTreatment of choiceBone painIntravenous pamidronateBisphosphonate treatmentSignificant morbidityCancer patientsPotent bisphosphonateStandard treatmentBone resorptionSurrogate markerClinical trialsCommon siteMetastatic cancerBreast cancerMorbidityMetastasisPatientsLife measurementsTherapyComplicationsPamidronate