2013
Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma
Su SC, Hu X, Kenney PA, Merrill MM, Babaian KN, Zhang XY, Maity T, Yang SF, Lin X, Wood CG. Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma. Clinical Cancer Research 2013, 19: 6461-6472. PMID: 24122794, PMCID: PMC4191899, DOI: 10.1158/1078-0432.ccr-13-1284.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAnimalsCarcinogenesisCarcinoma, Renal CellCell Line, TumorCell MovementDrug Resistance, NeoplasmFemaleHuman Umbilical Vein Endothelial CellsHumansIndolesKidney NeoplasmsLysophospholipidsMiceMice, Inbred BALB CMice, NudeMicrovesselsNeoplasm InvasivenessPhosphoric Diester HydrolasesPyrrolesSignal TransductionSunitinibTranscriptomeTumor BurdenXenograft Model Antitumor AssaysConceptsLPA receptor 1Lysophosphatidic acidATX-LPAResistance of RCCRenal cell carcinomaGene expression profilesExtracellular lysophospholipase DRCC cell linesTarget genesCell motilityEndothelial cellsExpression profilesIntracellular signalingInvasion responsesRCC tumorigenesisHuman renal cell carcinomaSignaling AxisSensitivity of RCCRCC cellsFunctional roleXenograft modelAltered expressionRenal tumorigenesisCell carcinomaLysophospholipase D
2010
Novel ZEB1 expression in bladder tumorigenesis
Kenney PA, Wszolek MF, Rieger‐Christ K, Neto BS, Gould JJ, Harty NJ, Mosquera JM, Zeheb R, Loda M, Darling DS, Libertino JA, Summerhayes IC. Novel ZEB1 expression in bladder tumorigenesis. BJU International 2010, 107: 656-663. PMID: 20735391, DOI: 10.1111/j.1464-410x.2010.09489.x.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transitionTransitional cell carcinomaZEB1 expressionNuclear ZEB1 expressionTissue microarrayBladder tumorsTumor progressionGrade I/IIBladder tumorigenesisMuscle-invasive UCBCancer-specific survivalGrade III tumorsNormal bladder mucosaExpression levelsExpression of ZEB1Underlying cellular changesCell linesBladder cell linesUM-UC-3Bladder tumor progressionProtein expression levelsBladder carcinoma cell lineInvasive UCBWestern blot analysisNodal involvement