2020
Redefining the Role of Surgical Management of Metastatic Renal Cell Carcinoma
Hsiang WR, Kenney PA, Leapman MS. Redefining the Role of Surgical Management of Metastatic Renal Cell Carcinoma. Current Oncology Reports 2020, 22: 35. PMID: 32170461, DOI: 10.1007/s11912-020-0895-y.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaSystemic therapyRenal cell carcinomaCytoreductive nephrectomySurgical therapyCell carcinomaManagement of mRCCPoor-risk metastatic renal cell carcinomaInitial systemic therapyReviewThe treatment landscapeTargeted therapy eraUpfront cytoreductive nephrectomyViable treatment approachSequence of surgeryTherapy eraTreatment landscapeUnselected patientsSurgical managementSummaryRecent evidenceRecent FindingsOneTreatment approachesNephrectomyTherapyOptimal rolePatients
2019
Outcomes for urologic oncology procedures: are there differences between academic and community hospitals?
Syed JS, Abello A, Nguyen J, Lee AJH, Desloges JJ, Leapman MS, Kenney PA. Outcomes for urologic oncology procedures: are there differences between academic and community hospitals? World Journal Of Urology 2019, 38: 1187-1193. PMID: 31420696, DOI: 10.1007/s00345-019-02902-8.Peer-Reviewed Original ResearchConceptsLength of stayCommunity hospitalAcademic hospitalReadmission ratesRadical cystectomyHospital-based outcomesDirect costsMean direct costUrologic oncology proceduresStudent's t-testCase mix indexIndex admissionVizient databaseRadical nephroureterectomyPartial cystectomySurgical treatmentUrologic malignanciesOncologic proceduresPartial nephrectomyCystectomyOncology proceduresAcademic centersHospitalProstatectomyStay
2015
Prediction of Pulmonary Metastasis in Renal Cell Carcinoma Patients with Indeterminate Pulmonary Nodules
Adibi M, Kenney PA, Thomas AZ, Borregales LD, Nogueras-González GM, Wang X, Devine CE, Karam JA, Wood CG. Prediction of Pulmonary Metastasis in Renal Cell Carcinoma Patients with Indeterminate Pulmonary Nodules. European Urology 2015, 69: 352-360. PMID: 26382085, DOI: 10.1016/j.eururo.2015.08.053.Peer-Reviewed Original ResearchConceptsLung metastasis-free survivalIndeterminate pulmonary nodulesRenal cell carcinomaAdvanced renal cell carcinomaPulmonary metastasesCell carcinomaPulmonary nodulesMultivariable Cox regression modelsRenal cell carcinoma patientsRadical nephrectomy patientsCell carcinoma patientsMetastasis-free survivalCox regression modelIndividualized risk stratificationAvailable preoperative imagingKidney cancer patientsSmall lung nodulesThree yrNephrectomy patientsPreoperative chestOverall cohortCarcinoma patientsDistant metastasisPathological variablesRadical nephrectomy
2013
Preoperative Pulmonary Embolism Does Not Predict Poor Postoperative Outcomes in Patients with Renal Cell Carcinoma and Venous Thrombus
Abel EJ, Wood CG, Eickstaedt N, Fang JE, Kenney P, Bagrodia A, Youssef RF, Sagalowsky AI, Margulis V. Preoperative Pulmonary Embolism Does Not Predict Poor Postoperative Outcomes in Patients with Renal Cell Carcinoma and Venous Thrombus. Journal Of Urology 2013, 190: 452-457. PMID: 23434945, DOI: 10.1016/j.juro.2013.02.033.Peer-Reviewed Original ResearchConceptsPreoperative pulmonary embolismCancer-specific survivalRenal cell carcinomaPulmonary embolismPoor postoperative outcomesCell carcinomaSpecific survivalVenous thrombiPostoperative outcomesMetastatic renal cell carcinomaCox proportional hazards analysisWorse cancer-specific survivalConsecutive patient recordsHigh-level thrombusProportional hazards analysisHigher T stagePostoperative disease recurrencePerioperative mortalityMedian followupDisease recurrenceTumor thrombusT stageTertiary hospitalEarly mortalityMulticenter study
2012
Integration of Surgery and Systemic Therapy for Renal Cell Carcinoma
Kenney PA, Wood CG. Integration of Surgery and Systemic Therapy for Renal Cell Carcinoma. Urologic Clinics Of North America 2012, 39: 211-231. PMID: 22487764, DOI: 10.1016/j.ucl.2012.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, HormonalCarcinoma, Renal CellChemotherapy, AdjuvantCombined Modality TherapyFemaleHumansImmunotherapyKidney NeoplasmsMaleNeoadjuvant TherapyNeoplasm InvasivenessNeoplasm StagingNephrectomyPrognosisRadiotherapy, AdjuvantRisk AssessmentSurvival AnalysisTreatment OutcomeConceptsRenal cell carcinomaSystemic therapyCell carcinomaMetastatic renal cell carcinomaAdvanced nonmetastatic diseaseUpfront cytoreductive nephrectomyIntegration of surgeryCytoreductive nephrectomyCytoreductive surgeryNeoadjuvant therapyNonmetastatic diseaseAdjuvant therapyMetastatic diseaseAppropriate patientsTherapySurgeryDiseaseCurrent roleNephrectomyFurther studiesCarcinomaPotential benefitsPatientsTrialsHIGHER PERIOPERATIVE MORBIDITY AND IN‐HOSPITAL MORTALITY IN PATIENTS WITH END‐STAGE RENAL DISEASE UNDERGOING NEPHRECTOMY FOR NON‐METASTATIC KIDNEY CANCER: A POPULATION‐BASED ANALYSIS
Kenney PA, Karam JA. HIGHER PERIOPERATIVE MORBIDITY AND IN‐HOSPITAL MORTALITY IN PATIENTS WITH END‐STAGE RENAL DISEASE UNDERGOING NEPHRECTOMY FOR NON‐METASTATIC KIDNEY CANCER: A POPULATION‐BASED ANALYSIS. BJU International 2012, 110: e191-e191. PMID: 22321381, DOI: 10.1111/j.1464-410x.2012.11018.x.Peer-Reviewed Original Research
2011
Nonclamping partial nephrectomy: towards improved nephron sparing
Wszolek MF, Kenney PA, Libertino JA. Nonclamping partial nephrectomy: towards improved nephron sparing. Nature Reviews Urology 2011, 8: 523-527. PMID: 21811227, DOI: 10.1038/nrurol.2011.103.Peer-Reviewed Original Research
2010
Comparison of hilar clamping and non‐hilar clamping partial nephrectomy for tumours involving a solitary kidney
Wszolek MF, Kenney PA, Lee Y, Libertino JA. Comparison of hilar clamping and non‐hilar clamping partial nephrectomy for tumours involving a solitary kidney. BJU International 2010, 107: 1886-1892. PMID: 21070570, DOI: 10.1111/j.1464-410x.2010.09713.x.Peer-Reviewed Original ResearchConceptsLatest glomerular filtration ratesGlomerular filtration rateNon-clamping groupEarly glomerular filtration ratePreoperative glomerular filtration rateSolitary functional kidneyHilar clampingPartial nephrectomyClamping groupSolitary kidneySpecific survivalRenal cell carcinoma-specific survivalInstitutional review board-approved retrospective reviewSurgical margin positivity ratesFunctional kidneyMean ischaemia timeSimilar cancer controlRenal Disease equationLocal recurrence rateMargin positivity ratesModification of DietCarcinoma-specific survivalSpectrum of complicationsNumber of tumorsAutotransplant proceduresNon‐clamped partial nephrectomy: techniques and surgical outcomes
Smith GL, Kenney PA, Lee Y, Libertino JA. Non‐clamped partial nephrectomy: techniques and surgical outcomes. BJU International 2010, 107: 1054-1058. PMID: 21040369, DOI: 10.1111/j.1464-410x.2010.09798.x.Peer-Reviewed Original ResearchConceptsPartial nephrectomyVascular clampingGroup AGroup BSolitary kidneyRenal functionBlood lossOncological efficacyPercentage changeVon Hippel-Lindau diseaseFour-variable ModificationRenal vascular clampingMedian tumor sizeRate of complicationsRenal Disease equationGlomerular filtration rateSubset of patientsMedian percentage changeRate of recurrencePositive margin rateHippel-Lindau diseaseUnclamped groupPerioperative deathsPreoperative eGFRRetrospective review