Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis
Gupta K, Levinsohn J, Linderman G, Chen D, Sun TY, Dong D, Taketo MM, Bosenberg M, Kluger Y, Choate K, Myung P. Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis. Developmental Cell 2018, 48: 17-31.e6. PMID: 30595533, PMCID: PMC6361530, DOI: 10.1016/j.devcel.2018.11.032.Peer-Reviewed Original ResearchConceptsDermal condensatesSingle-cell RNA sequencingUnbiased single-cell RNA sequencingWnt/β-catenin signalingΒ-catenin signalingTranscriptional statesDifferentiation trajectoriesAppendage morphogenesisRNA sequencingHF morphogenesisCellular eventsRecent progenyCell differentiationMorphogenesisClusters of cellsMolecular differencesDistinctive populationCell analysisCellsDifferentiationHF developmentProgenySignalingDC cellsSequencingThe origins of skin diversity: lessons from dermal fibroblasts
Myung P, Andl T, Atit R. The origins of skin diversity: lessons from dermal fibroblasts. Development 2022, 149 PMID: 36444877, PMCID: PMC10112899, DOI: 10.1242/dev.200298.Peer-Reviewed Original ResearchConceptsFibroblast subtypesSingle-cell levelWnt/β-cateninLineage diversificationHair follicle growthDermal developmentDermal fibroblastsExtraordinary diversityPositional signalsNatural variationFibroblast heterogeneityΒ-cateninDevelopmental originsDiverse groupMolecular heterogeneityCentral roleDiversityFibroblastsFollicle growthImportant roleLineagesSpeciesDiversificationDifferentiationOrigin