2014
β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche
Deschene ER, Myung P, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I, Greco V. β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche. Science 2014, 343: 1353-1356. PMID: 24653033, PMCID: PMC4096864, DOI: 10.1126/science.1248373.Peer-Reviewed Original ResearchConceptsWild-type cellsWnt/β-catenin signalingΒ-catenin signalingΒ-catenin activationMouse hair follicle stem cellsΒ-cateninStem cell nicheHair follicle stem cellsFollicle stem cellsNiche signalsMutant cellsCell divisionCell nicheCoordinated regenerationHair growthWnt ligandsCellular displacementCell behaviorStem cellsHair regenerationTissue growthSignalingCellsTissue regenerationActivation
2011
Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration
Rabbani P, Takeo M, Chou W, Myung P, Bosenberg M, Chin L, Taketo MM, Ito M. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration. Cell 2011, 145: 941-955. PMID: 21663796, PMCID: PMC3962257, DOI: 10.1016/j.cell.2011.05.004.Peer-Reviewed Original ResearchConceptsSecondary hair germMelanocyte stem cellsStem cellsStem cell behaviorStem cell populationHair regenerationHair follicle formationPigment-producing melanocytesHair follicle regenerationHair follicle bulgeEpithelial stem cellsGenetic mouse modelsCoordinated activationWntKey pathwaysCell behaviorWnt activationFollicle bulgeFollicle regenerationComplex organHair germFollicle formationCell populationsMcSCsCells