Featured Publications
Decomposing a deterministic path to mesenchymal niche formation by two intersecting morphogen gradients
Qu R, Gupta K, Dong D, Jiang Y, Landa B, Saez C, Strickland G, Levinsohn J, Weng PL, Taketo MM, Kluger Y, Myung P. Decomposing a deterministic path to mesenchymal niche formation by two intersecting morphogen gradients. Developmental Cell 2022, 57: 1053-1067.e5. PMID: 35421372, PMCID: PMC9050909, DOI: 10.1016/j.devcel.2022.03.011.Peer-Reviewed Original ResearchConceptsMorphogen gradientsCell fate specificationWnt/β-cateninFate specificationShape tissuesOrgan formationCell fateDermal condensatesGenetic perturbationsNiche formationDifferentiation processSpatiotemporal patterningCell behaviorΒ-cateninMore intermediatesComputational approachProliferationMorphogenesisScRNAOrganogenesisShhKey componentProgenitorsCritical transitionDKK1The origins of skin diversity: lessons from dermal fibroblasts
Myung P, Andl T, Atit R. The origins of skin diversity: lessons from dermal fibroblasts. Development 2022, 149 PMID: 36444877, PMCID: PMC10112899, DOI: 10.1242/dev.200298.Peer-Reviewed Original ResearchConceptsFibroblast subtypesSingle-cell levelWnt/β-cateninLineage diversificationHair follicle growthDermal developmentDermal fibroblastsExtraordinary diversityPositional signalsNatural variationFibroblast heterogeneityΒ-cateninDevelopmental originsDiverse groupMolecular heterogeneityCentral roleDiversityFibroblastsFollicle growthImportant roleLineagesSpeciesDiversificationDifferentiationOrigin
2012
Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration
Myung PS, Takeo M, Ito M, Atit RP. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration. Journal Of Investigative Dermatology 2012, 133: 31-41. PMID: 22810306, PMCID: PMC3479363, DOI: 10.1038/jid.2012.230.Peer-Reviewed Original ResearchConceptsWnt ligand secretionHair follicle epitheliumFollicle growthHair follicle growthWnt ligandsEpithelial Wnt ligandsHair cycle arrestFollicular epitheliumLigand secretionFollicle epitheliumWnt/β-catenin activationΒ-cateninAnagen inductionWnt/β-cateninStem cell markersΒ-catenin activationPotential cellular targetsHair follicle stem cellsCellular sourceCell markersHair disordersFollicle stem cellsHair folliclesEpitheliumHair follicle regeneration