Featured Publications
Decomposing a deterministic path to mesenchymal niche formation by two intersecting morphogen gradients
Qu R, Gupta K, Dong D, Jiang Y, Landa B, Saez C, Strickland G, Levinsohn J, Weng PL, Taketo MM, Kluger Y, Myung P. Decomposing a deterministic path to mesenchymal niche formation by two intersecting morphogen gradients. Developmental Cell 2022, 57: 1053-1067.e5. PMID: 35421372, PMCID: PMC9050909, DOI: 10.1016/j.devcel.2022.03.011.Peer-Reviewed Original ResearchConceptsMorphogen gradientsCell fate specificationWnt/β-cateninFate specificationShape tissuesOrgan formationCell fateDermal condensatesGenetic perturbationsNiche formationDifferentiation processSpatiotemporal patterningCell behaviorΒ-cateninMore intermediatesComputational approachProliferationMorphogenesisScRNAOrganogenesisShhKey componentProgenitorsCritical transitionDKK1Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis
Gupta K, Levinsohn J, Linderman G, Chen D, Sun TY, Dong D, Taketo MM, Bosenberg M, Kluger Y, Choate K, Myung P. Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis. Developmental Cell 2018, 48: 17-31.e6. PMID: 30595533, PMCID: PMC6361530, DOI: 10.1016/j.devcel.2018.11.032.Peer-Reviewed Original ResearchConceptsDermal condensatesSingle-cell RNA sequencingUnbiased single-cell RNA sequencingWnt/β-catenin signalingΒ-catenin signalingTranscriptional statesDifferentiation trajectoriesAppendage morphogenesisRNA sequencingHF morphogenesisCellular eventsRecent progenyCell differentiationMorphogenesisClusters of cellsMolecular differencesDistinctive populationCell analysisCellsDifferentiationHF developmentProgenySignalingDC cellsSequencingThe origins of skin diversity: lessons from dermal fibroblasts
Myung P, Andl T, Atit R. The origins of skin diversity: lessons from dermal fibroblasts. Development 2022, 149 PMID: 36444877, PMCID: PMC10112899, DOI: 10.1242/dev.200298.Peer-Reviewed Original ResearchConceptsFibroblast subtypesSingle-cell levelWnt/β-cateninLineage diversificationHair follicle growthDermal developmentDermal fibroblastsExtraordinary diversityPositional signalsNatural variationFibroblast heterogeneityΒ-cateninDevelopmental originsDiverse groupMolecular heterogeneityCentral roleDiversityFibroblastsFollicle growthImportant roleLineagesSpeciesDiversificationDifferentiationOrigin
2022
Segmental basaloid follicular hamartomas derive from a post‐zygotic SMO p.L412F pathogenic variant and express hair follicle development‐related proteins in a pattern that distinguish them from basal cell carcinomas
Atzmony L, Ugwu N, Bercovitch LG, Robinson‐Bostom L, Ko CJ, Myung P, Choate KA. Segmental basaloid follicular hamartomas derive from a post‐zygotic SMO p.L412F pathogenic variant and express hair follicle development‐related proteins in a pattern that distinguish them from basal cell carcinomas. American Journal Of Medical Genetics Part A 2022, 188: 3525-3530. PMID: 35972041, PMCID: PMC9669121, DOI: 10.1002/ajmg.a.62951.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Basal CellHair FollicleHamartomaHedgehog ProteinsHumansSkin DiseasesSkin NeoplasmsSmoothened ReceptorConceptsBasal cell carcinomaCell carcinomaFollicular hamartomaProliferation indexBasaloid skin tumorsSporadic basal cell carcinomasBasaloid follicular hamartomaKi-67 expressionLow proliferation indexCentral nervous systemWhole-exome sequencingSystemic involvementExpression of hedgehogMultiple lesionsSkin tumorsWnt/beta-catenin pathwayBasaloid lesionsNervous systemVariable involvementPathogenic variantsSegmental distributionPost-zygotic mutational eventSOX-9 expressionNormal tissuesExome sequencing
2018
Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing
Lim CH, Sun Q, Ratti K, Lee SH, Zheng Y, Takeo M, Lee W, Rabbani P, Plikus MV, Cain JE, Wang DH, Watkins DN, Millar S, Taketo MM, Myung P, Cotsarelis G, Ito M. Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing. Nature Communications 2018, 9: 4903. PMID: 30464171, PMCID: PMC6249328, DOI: 10.1038/s41467-018-07142-9.Peer-Reviewed Original ResearchConceptsSonic hedgehog pathwayMechanisms of scarringHair follicle neogenesisHF neogenesisFibrotic repairScarring woundsMurine skinShh overexpressionWound repairHair follicle regenerationWound healingFollicle neogenesisHedgehog pathwayDermal papillaWnt activationFibrosisWoundsScarringHealingSignal activationNeogenesisActivation resultsMammalian woundsActivationFollicle regenerationCutaneous immunohistochemical staining pattern of p53β isoforms
Ko CJ, Myung P, Leffell DJ, Bourdon JC. Cutaneous immunohistochemical staining pattern of p53β isoforms. Journal Of Clinical Pathology 2018, 71: 1120. PMID: 30305316, DOI: 10.1136/jclinpath-2018-205098.Peer-Reviewed Original ResearchConceptsSquamous tumorsMarkers of differentiationSquamous proliferationIsoforms of p53Mutational statusHair folliclesP53 pathwayDomain mutationsExact biological significanceP53Differentiated layersSkinP53 isoformsSuch mutationsIsoformsDifferent isoformsNumerous functionsTumorsCancerMutationsFolliclesBiological significance
2015
Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool
Mesa KR, Rompolas P, Zito G, Myung P, Sun TY, Brown S, Gonzalez DG, Blagoev KB, Haberman AM, Greco V. Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Nature 2015, 522: 94-97. PMID: 25849774, PMCID: PMC4457634, DOI: 10.1038/nature14306.Peer-Reviewed Original Research
2014
β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche
Deschene ER, Myung P, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I, Greco V. β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche. Science 2014, 343: 1353-1356. PMID: 24653033, PMCID: PMC4096864, DOI: 10.1126/science.1248373.Peer-Reviewed Original ResearchConceptsWild-type cellsWnt/β-catenin signalingΒ-catenin signalingΒ-catenin activationMouse hair follicle stem cellsΒ-cateninStem cell nicheHair follicle stem cellsFollicle stem cellsNiche signalsMutant cellsCell divisionCell nicheCoordinated regenerationHair growthWnt ligandsCellular displacementCell behaviorStem cellsHair regenerationTissue growthSignalingCellsTissue regenerationActivation
2012
Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration
Myung PS, Takeo M, Ito M, Atit RP. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration. Journal Of Investigative Dermatology 2012, 133: 31-41. PMID: 22810306, PMCID: PMC3479363, DOI: 10.1038/jid.2012.230.Peer-Reviewed Original ResearchConceptsWnt ligand secretionHair follicle epitheliumFollicle growthHair follicle growthWnt ligandsEpithelial Wnt ligandsHair cycle arrestFollicular epitheliumLigand secretionFollicle epitheliumWnt/β-catenin activationΒ-cateninAnagen inductionWnt/β-cateninStem cell markersΒ-catenin activationPotential cellular targetsHair follicle stem cellsCellular sourceCell markersHair disordersFollicle stem cellsHair folliclesEpitheliumHair follicle regenerationDissecting the bulge in hair regeneration
Myung P, Ito M. Dissecting the bulge in hair regeneration. Journal Of Clinical Investigation 2012, 122: 448-454. PMID: 22293183, PMCID: PMC3266778, DOI: 10.1172/jci57414.Peer-Reviewed Original Research
2011
Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration
Rabbani P, Takeo M, Chou W, Myung P, Bosenberg M, Chin L, Taketo MM, Ito M. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration. Cell 2011, 145: 941-955. PMID: 21663796, PMCID: PMC3962257, DOI: 10.1016/j.cell.2011.05.004.Peer-Reviewed Original ResearchConceptsSecondary hair germMelanocyte stem cellsStem cellsStem cell behaviorStem cell populationHair regenerationHair follicle formationPigment-producing melanocytesHair follicle regenerationHair follicle bulgeEpithelial stem cellsGenetic mouse modelsCoordinated activationWntKey pathwaysCell behaviorWnt activationFollicle bulgeFollicle regenerationComplex organHair germFollicle formationCell populationsMcSCsCells
2009
Defining the hair follicle stem cell (Part II)
Myung P, Andl T, Ito M. Defining the hair follicle stem cell (Part II). Journal Of Cutaneous Pathology 2009, 36: 1134-1137. PMID: 19712246, DOI: 10.1111/j.1600-0560.2009.01412.x.Peer-Reviewed Original ResearchDefining the hair follicle stem cell (Part I)
Myung P, Andl T, Ito M. Defining the hair follicle stem cell (Part I). Journal Of Cutaneous Pathology 2009, 36: 1031-1034. PMID: 19674210, DOI: 10.1111/j.1600-0560.2009.01396.x.Peer-Reviewed Original Research