A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease
Sun Q, Lee W, Mohri Y, Takeo M, Lim CH, Xu X, Myung P, Atit RP, Taketo MM, Moubarak RS, Schober M, Osman I, Gay DL, Saur D, Nishimura EK, Ito M. A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease. Nature Communications 2019, 10: 5023. PMID: 31685822, PMCID: PMC6828673, DOI: 10.1038/s41467-019-12733-1.Peer-Reviewed Original ResearchConceptsMouse modelNovel mouse modelMelanoma progression modelDeadly skin cancerAnimal modelsSkin cancerBona fide sourceAdvanced stageMelanoma inductionMalignant transformationHuman melanomaMelanomaGene signatureAnagen onsetMolecular profilingMelanoma initiationMelanocyte stem cellsNormal WntStem cellsProgression modelHuman diseasesRecent studiesCancerDiseaseProgression