2024
Novel FOXL2 Mutation in an Ovarian Adult Granulosa Cell Tumor: Report of a Case With Diagnostic and Clinicopathologic Implications
Nagy A, Niu N, Ratner E, Hui P, Buza N. Novel FOXL2 Mutation in an Ovarian Adult Granulosa Cell Tumor: Report of a Case With Diagnostic and Clinicopathologic Implications. International Journal Of Gynecological Pathology 2024, 43: 631-636. PMID: 38426544, DOI: 10.1097/pgp.0000000000001024.Peer-Reviewed Original ResearchAdult granulosa cell tumorGranulosa cell tumorsOvarian sex cord-stromal tumorsSex cord-stromal tumorsCord-stromal tumorsCell tumorsFOXL2 mutationMutation c.Fibromatous stromaMalignant ovarian sex cord-stromal tumorAdjuvant vaginal cuff brachytherapyOvarian adult granulosa cell tumorsBilateral salpingo-oophorectomyRight ovarian massVaginal cuff brachytherapyAtypical endometrial hyperplasiaSuperficial myometrial invasionRoutine molecular testingUniform tumor cellsEndometrioid endometrial adenocarcinomaNested growth patternPoint mutation c.Months follow-upSalpingo-oophorectomyTotal hysterectomy
2021
Molecular Diagnosis
Weisman P, Wei J, Hui P. Molecular Diagnosis. Practical Anatomic Pathology 2021, 417-431. DOI: 10.1007/978-3-030-68608-6_16.Peer-Reviewed Original ResearchGynecologic pathologyMolecular diagnostic techniquesGynecologic tumorsCell tumorsTherapeutic implicationsOvarian sex cord-stromal tumorsHigh-grade endometrial stromal sarcomaSertoli-Leydig cell tumorSex cord-stromal tumorsJuvenile granulosa cell tumorMolecular diagnostic findingsSpindle cell leiomyosarcomaEndometrial stromal sarcomaGranulosa cell tumorsGestational trophoblastic diseaseLow mitotic ratePeutz-Jeghers syndromeDiagnostic techniquesFibrosarcoma-like tumorsStromal sarcomaOvarian neoplasiaSporadic settingHistological featuresTrophoblastic diseaseDiagnostic findings
2020
Lack of genetic homozygosity in prepubertal teratomas: divergent pathogenesis distinct from that of teratomas in adolescents
Snir OL, DeJoseph M, Wu X, Rottmann D, Wong S, Buza N, Hui P. Lack of genetic homozygosity in prepubertal teratomas: divergent pathogenesis distinct from that of teratomas in adolescents. Laboratory Investigation 2020, 100: 1447-1454. PMID: 32694569, DOI: 10.1038/s41374-020-0468-6.Peer-Reviewed Original ResearchConceptsOvarian teratomaPatient ageImmature teratomaTesticular teratomaMature teratomaSacrococcygeal teratomaMixed germ cell tumorGerm cell tumorsMature ovarian teratomaChildren 18 yearsDivergent pathogenesisGenetic zygosityPrepubertal teratomasCell tumorsGonadal teratomaTeratomaGenetic homozygosityNormal tissuesPatientsGerm cell developmentSacrococcygealAgeCell developmentDepartmental archivesGerm cells
2018
FOXL2 Mutation Analysis of Ovarian Sex Cord-Stromal Tumors
Buza N, Wong S, Hui P. FOXL2 Mutation Analysis of Ovarian Sex Cord-Stromal Tumors. International Journal Of Gynecological Pathology 2018, 37: 305-315. PMID: 28700438, DOI: 10.1097/pgp.0000000000000426.Peer-Reviewed Original ResearchConceptsSex cord-stromal tumorsAdult granulosa cell tumorGranulosa cell tumorsOvarian sex cord-stromal tumorsCell tumorsReticulin patternFOXL2 mutationStaining patternSertoli-Leydig cell tumorFOXL2 mutation statusAbundant pale cytoplasmSingle institutional cohortThird of casesWild-type tumorsFOXL2 mutation analysisNegative tumorsPositive tumorsTumor sizeReticulin stainingType tumorsPale cytoplasmNuclear atypiaMutation statusPositive casesTumors
2017
Frequent homozygosity in both mature and immature ovarian teratomas: a shared genetic basis of tumorigenesis
Snir OL, DeJoseph M, Wong S, Buza N, Hui P. Frequent homozygosity in both mature and immature ovarian teratomas: a shared genetic basis of tumorigenesis. Modern Pathology 2017, 30: 1467-1475. PMID: 28664933, DOI: 10.1038/modpathol.2017.66.Peer-Reviewed Original ResearchConceptsMixed germ cell tumorGerm cell tumorsPure immature teratomaImmature teratomaCell tumorsMature teratomaGenetic zygosityMixed ovarian germ cell tumorOvarian germ cell tumorsOvarian immature teratomaImmature ovarian teratomaDifferent pathogenetic pathwaysMature cystic teratomaImmature teratoma componentsDifferent biological behaviorTeratoma componentsRate of homozygosityCystic teratomaOvarian teratomaTumor recurrenceCommon cellular originPathogenetic pathwaysGrade 2TumorsTeratoma
2010
Nonepithelial Tumor of Ovary
Chhieng D, Hui P. Nonepithelial Tumor of Ovary. Current Clinical Pathology 2010, 173-191. DOI: 10.1007/978-1-60761-164-6_11.Peer-Reviewed Original ResearchEpithelial Neoplasms of Ovary
Chhieng D, Hui P. Epithelial Neoplasms of Ovary. Current Clinical Pathology 2010, 145-172. DOI: 10.1007/978-1-60761-164-6_10.Peer-Reviewed Original ResearchSurface epithelial tumorsGerm cell tumorsCell tumorsEpithelial tumorsOvarian neoplasmsPrimary ovarian neoplasmsSex cord tumorSex cord differentiationPrimary ovarian tumorsOvarian stromal cellsTransitional cell tumorsBreast primaryHistological subtypesOvarian tumorsClinical behaviorClinicopathological stagingEpithelial neoplasmsSecondary tumorsClear cellsTheca cellsGranulosa cellsCell originTumorsLeydig cellsStromal cells
2008
Expression of CD56 and WT1 in Ovarian Stroma and Ovarian Stromal Tumors
He H, Luthringer DJ, Hui P, Lau SK, Weiss LM, Chu PG. Expression of CD56 and WT1 in Ovarian Stroma and Ovarian Stromal Tumors. The American Journal Of Surgical Pathology 2008, 32: 884-890. PMID: 18425046, DOI: 10.1097/pas.0b013e3181609d59.Peer-Reviewed Original ResearchConceptsSpindle cell sarcomaSpindle cell tumorsOvarian stromal cellsUterine smooth muscle tumorsExpression of CD56Endometrial stromal tumorsOvarian fibromaSmooth muscle tumorsCell sarcomaCell tumorsOvarian cellular fibromasSmooth muscle actinStromal tumorsOvarian stromaProgesterone receptorNormal ovariesStromal cellsOvarian fibrothecomaOvarian leiomyomaMuscle tumorsCellular fibromaMuscle actinOvarian stromal originOvarian stromal tumorsEndometrial stromal cells
2005
Atypical angiomyolipoma of kidney in a patient with tuberous sclerosis: a case report with p53 gene mutation analysis.
Ma L, Kowalski D, Javed K, Hui P. Atypical angiomyolipoma of kidney in a patient with tuberous sclerosis: a case report with p53 gene mutation analysis. Archives Of Pathology & Laboratory Medicine 2005, 129: 676-9. PMID: 15859641, DOI: 10.5858/2005-129-0676-aaokia.Peer-Reviewed Original ResearchConceptsHMB-45Tuberous sclerosisP53 mutationsPerivascular epithelioid cell tumorCommon benign mesenchymal tumorsFocal p53 immunoreactivityP53 gene mutation analysisSmooth muscle-like cellsEpithelioid cell tumorBenign mesenchymal tumorsMuscle-like cellsGene mutation analysisAtypical angiomyolipomaEpithelioid angiomyolipomaRenal angiomyolipomaCase reportMesenchymal tumorsCell tumorsAML progressionAML casesP53 immunoreactivityFrequent mitosesP53 abnormalitiesAngiomyolipomaEpithelioid cells