2022
Correlative Assessment of p53 Immunostaining Patterns and TP53 Mutation Status by Next-Generation Sequencing in High-Grade Endometrial Carcinomas
Matsumoto N, Manrai P, Rottmann D, Wu X, Assem H, Hui P, Buza N. Correlative Assessment of p53 Immunostaining Patterns and TP53 Mutation Status by Next-Generation Sequencing in High-Grade Endometrial Carcinomas. International Journal Of Gynecological Pathology 2022, 42: 567-575. PMID: 36730675, DOI: 10.1097/pgp.0000000000000930.Peer-Reviewed Original ResearchConceptsHigh-grade endometrial carcinomasEndometrial carcinomaEndometrioid endometrial carcinomaTP53 mutation statusP53 immunohistochemistrySerous componentIHC staining patternNext-generation sequencing resultsNuclear overexpressionGrade 3 endometrioid endometrial carcinomaMutation statusTP53 mutationsCytoplasmic stainingStaining patternSerous endometrial carcinomaAberrant p53 expressionMixed endometrial carcinomasClinical prognosisSurrogate markerAberrant p53 proteinTherapeutic decisionsIHC patternsTP53 alterationsTumor histotypesP53 expression
2018
FOXL2 Mutation Analysis of Ovarian Sex Cord-Stromal Tumors
Buza N, Wong S, Hui P. FOXL2 Mutation Analysis of Ovarian Sex Cord-Stromal Tumors. International Journal Of Gynecological Pathology 2018, 37: 305-315. PMID: 28700438, DOI: 10.1097/pgp.0000000000000426.Peer-Reviewed Original ResearchConceptsSex cord-stromal tumorsAdult granulosa cell tumorGranulosa cell tumorsOvarian sex cord-stromal tumorsCell tumorsReticulin patternFOXL2 mutationStaining patternSertoli-Leydig cell tumorFOXL2 mutation statusAbundant pale cytoplasmSingle institutional cohortThird of casesWild-type tumorsFOXL2 mutation analysisNegative tumorsPositive tumorsTumor sizeReticulin stainingType tumorsPale cytoplasmNuclear atypiaMutation statusPositive casesTumors
2014
Egg Donor Pregnancy
Buza N, Hui P. Egg Donor Pregnancy. International Journal Of Gynecological Pathology 2014, 33: 507-510. PMID: 25083967, DOI: 10.1097/pgp.0b013e3182a1028b.Peer-Reviewed Original ResearchConceptsDonor pregnanciesMedical recordsClinical gestational ageFirst case reportPatients' medical recordsPositive nuclear stainingNormal staining patternVillous stromal cellsMaternal decidual tissuesDNA genotypingChorionic villous tissueGestational ageUnderwent dilationCase reportUterine contentsVillous tissueMorphologic featuresStromal cellsPregnancyStaining patternComplete hydatidiformPartial hydatidiformChorionic villiNuclear stainingMicroscopic evaluation
2007
Expression of Mucins, SIMA, Villin, and CDX2 in Small-Intestinal Adenocarcinoma
Zhang MQ, Lin F, Hui P, Chen ZM, Ritter JH, Wang HL. Expression of Mucins, SIMA, Villin, and CDX2 in Small-Intestinal Adenocarcinoma. American Journal Of Clinical Pathology 2007, 128: 808-816. PMID: 17951204, DOI: 10.1309/jaf3kvgjhqcj1qf9.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overAntigens, NeoplasmBiomarkers, TumorCDX2 Transcription FactorFemaleFluorescent Antibody Technique, IndirectHomeodomain ProteinsHumansImmunoenzyme TechniquesIntestinal NeoplasmsIntestine, SmallMaleMicrofilament ProteinsMiddle AgedMucinsNeoplasm ProteinsConceptsSmall intestinal mucin antigenSmall intestinal adenocarcinomaColorectal adenocarcinomaFocal staining patternExpression of mucinsFrequency of expressionMucin antigenFocal stainingPositive stainingDiffuse immunoreactivityAdenocarcinomaDiffuse stainingStaining patternMUC5ACMUC1MUC2Morphologic similaritiesStainingCDX2ExpressionVillinImmunoreactivityAntigenBiomarkers
2005
HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma: preferential expression of HMGA2 in malignant peripheral nerve sheath tumor
Hui P, Li N, Johnson C, De Wever I, Sciot R, Manfioletti G, Tallini G. HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma: preferential expression of HMGA2 in malignant peripheral nerve sheath tumor. Modern Pathology 2005, 18: 1519-1526. PMID: 16056249, DOI: 10.1038/modpathol.3800464.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsNerve sheath tumorsSheath tumorsSynovial sarcomaSYT-SSX fusion transcriptsRoutine surgical pathology practiceStaining patternMonophasic synovial sarcomaReal-time reverse transcription-polymerase chain reactionAvailable immunohistochemical markersReverse transcription-polymerase chain reactionSurgical pathology practiceTranscription-polymerase chain reactionExpression of HMGA2Nuclear staining patternHistological diagnosisPolymerase chain reactionProtein immunohistochemistryBiphasic tumorSignificant immunoreactivityImmunohistochemical markersImmunohistochemical stainingSarcomaGlandular component