2021
Molecular Diagnosis
Weisman P, Wei J, Hui P. Molecular Diagnosis. Practical Anatomic Pathology 2021, 417-431. DOI: 10.1007/978-3-030-68608-6_16.Peer-Reviewed Original ResearchGynecologic pathologyMolecular diagnostic techniquesGynecologic tumorsCell tumorsTherapeutic implicationsOvarian sex cord-stromal tumorsHigh-grade endometrial stromal sarcomaSertoli-Leydig cell tumorSex cord-stromal tumorsJuvenile granulosa cell tumorMolecular diagnostic findingsSpindle cell leiomyosarcomaEndometrial stromal sarcomaGranulosa cell tumorsGestational trophoblastic diseaseLow mitotic ratePeutz-Jeghers syndromeDiagnostic techniquesFibrosarcoma-like tumorsStromal sarcomaOvarian neoplasiaSporadic settingHistological featuresTrophoblastic diseaseDiagnostic findings
2020
Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease
Zheng XZ, Qin XY, Chen SW, Wang P, Zhan Y, Zhong PP, Buza N, Jin YL, Wu BQ, Hui P. Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease. Modern Pathology 2020, 33: 1979-1988. PMID: 32404958, DOI: 10.1038/s41379-020-0566-4.Peer-Reviewed Original ResearchConceptsNon-molar gestationsGestational trophoblastic diseaseTrophoblastic diseaseHigh riskGestational trophoblastic neoplasiaProducts of conceptionPatient demographicsClinical followClinical outcomesGynecology HospitalTrophoblastic neoplasiaBeijing ObstetricsFIGO criteriaChinese patientsClinical prognosisPatient managementLarge cohortGestationMolar gestationDiseaseGenetic abnormalitiesChromosomal monosomyChromosomal aneuploidyHydatidiformUniparental disomy
2011
Molecular Diagnosis of Gestational Trophoblastic Disease
Hui P. Molecular Diagnosis of Gestational Trophoblastic Disease. Current Clinical Pathology 2011, 161-178. DOI: 10.1007/978-1-61779-394-3_11.Peer-Reviewed Original ResearchMinimal histological abnormalitiesGestational trophoblastic diseaseAvailable ancillary studiesGestational trophoblastic disordersNormal pregnancyHistological diagnosisTrophoblastic diseaseGynecological pathologyHistological abnormalitiesAncillary studiesTrophoblastic disordersComplete hydatidiformPartial hydatidiformDaily practiceDiagnosisHydatidiformMolecular diagnosisSignificant percentagePathologistsHydropic abortusGenetic Basis of Gestational Trophoblastic Disease
Hui P. Genetic Basis of Gestational Trophoblastic Disease. Current Clinical Pathology 2011, 41-55. DOI: 10.1007/978-1-61779-394-3_3.Peer-Reviewed Original ResearchGestational trophoblastic diseasePlacental site trophoblastic tumorEpithelioid trophoblastic tumorTrophoblastic tumorIntermediate trophoblastTrophoblastic diseaseExaggerated placental site reactionChorionic villous trophoblastPlacental site noduleUnique clinical settingGestational choriocarcinomaSite reactionsMalignant tumorsLesional cellsProliferative lesionsProliferative disordersTrophoblastic cellsVillous trophoblastBiomarker expressionClinical settingImplantation sitesTumorsUnique genetic factorsRecent linkage studiesComplete hydatidiformGestational Choriocarcinoma
Hui P. Gestational Choriocarcinoma. Current Clinical Pathology 2011, 127-137. DOI: 10.1007/978-1-61779-394-3_8.Peer-Reviewed Original ResearchGestational choriocarcinomaMalignant tumorsMethotrexate-based chemotherapyMortality of patientsDecidua of pregnancyHematogenous spreadCure rateFatal malignancyTrophoblastic diseaseChemotherapy managementAggressive formChoriocarcinomaChorial villiTumorsTumor cellsSarcomaDiseaseChemotherapyPatientsPregnancyDramatic decreaseMalignancyMortalityPlacentaDeciduaUrinary hCG Screening in the Gynecologic Oncology Population
Richter C, Buza N, Hui P, Silasi D, Azodi M, Santin A, Rutherford T, Schwartz P. Urinary hCG Screening in the Gynecologic Oncology Population. Journal Of Gynecologic Surgery 2011, 27: 143-146. DOI: 10.1089/gyn.2010.0048.Peer-Reviewed Original ResearchGestational trophoblastic diseasePositive urine pregnancy testUrine pregnancy testGynecologic malignanciesUrinary hCGTrophoblastic diseasePregnancy testHuman chorionic gonadotropin testingClear cell ovarian carcinomaGynecologic oncology clinicGynecologic oncology populationRetrospective chart reviewHCG testingChart reviewNonpregnant patientsConsecutive patientsOncology populationPrimary peritonealOncology clinicVaginal carcinomaNongynecologic malignanciesUterine cancerFallopian tubeOvarian carcinomaOvarian cancer
2010
Gestational trophoblastic disease: histopathological diagnosis in the molecular era
Buza N, Hui P. Gestational trophoblastic disease: histopathological diagnosis in the molecular era. Diagnostic Histopathology 2010, 16: 526-537. DOI: 10.1016/j.mpdhp.2010.08.002.Peer-Reviewed Original ResearchGestational trophoblastic diseaseTrophoblastic diseaseTrophoblastic tumorCharacteristic histological featuresExaggerated placental sitePlacental site noduleEpithelioid trophoblastic tumorTumor-like conditionsFuture diagnostic algorithmsDiagnosis of hydatidiformUnique neoplasmGestational choriocarcinomaPlacental siteHistological featuresHistopathological diagnosisDifferential diagnosisDiagnostic criteriaMolecular testingPlacental trophoblastsProliferative disordersDiagnostic algorithmDiagnosisPartial hydatidiformHeterogeneous groupDiagnostic problemsGestational Trophoblastic Disease
Chhieng D, Hui P. Gestational Trophoblastic Disease. Current Clinical Pathology 2010, 131-138. DOI: 10.1007/978-1-60761-164-6_8.Peer-Reviewed Original ResearchExpression of glypican 3 in placental site trophoblastic tumor
Ou-Yang RJ, Hui P, Yang XJ, Zynger DL. Expression of glypican 3 in placental site trophoblastic tumor. Diagnostic Pathology 2010, 5: 64. PMID: 20868507, PMCID: PMC2954974, DOI: 10.1186/1746-1596-5-64.Peer-Reviewed Original ResearchConceptsPlacental site trophoblastic tumorPlacental site noduleInvasive cervical squamous cell carcinomaCervical squamous cell carcinomaNon-trophoblastic tumorsSquamous cell carcinomaTrophoblastic tumorCell carcinomaCytoplasmic stainingRare gestational trophoblastic neoplasmDiagnostic markerGestational trophoblastic neoplasmsGestational trophoblastic diseaseUseful diagnostic markerNon-neoplastic tissuesMembrane-bound heparan sulfate proteoglycanEndometrial adenocarcinomaUterine tumorsIntermediate trophoblastTrophoblastic diseaseTrophoblastic neoplasmsImmunohistochemical expressionHepatocellular carcinomaImmunohistochemical markersResultsEighty percent
2008
Epithelioid trophoblastic tumor: comparative genomic hybridization and diagnostic DNA genotyping
Xu ML, Yang B, Carcangiu ML, Hui P. Epithelioid trophoblastic tumor: comparative genomic hybridization and diagnostic DNA genotyping. Modern Pathology 2008, 22: 232-238. PMID: 18820674, DOI: 10.1038/modpathol.2008.165.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarcinoma, Squamous CellComparative Genomic HybridizationDiagnosis, DifferentialEndometrial NeoplasmsEpithelioid CellsFemaleGene Expression Regulation, NeoplasticGenetic TestingGenotypeGestational Trophoblastic DiseaseHumansItalyLung NeoplasmsMiddle AgedPregnancyUnited StatesUterine Cervical NeoplasmsConceptsEpithelioid trophoblastic tumorTrophoblastic tumorSquamous cell carcinomaUterine cervixComparative genomic hybridizationCommon squamous cell carcinomaChromosomal alterationsInvasive squamous cell carcinomaChorionic-type intermediate trophoblastGestational trophoblastic diseaseGenomic hybridizationDNA genotypingIntermediate trophoblastTrophoblastic diseaseAnatomic locationComparative genomic hybridization analysisTrophoblastic originTumorsGenomic hybridization analysisCervixNormal tissuesTrophoblastic natureConventional comparative genomic hybridizationCarcinomaChromosomal profile