2018
Biomarker P16 predicts progression risk of anal low-grade squamous intraepithelial lesions
Liu Y, Blakely M, Sigel K, Thin TH, Hui P, Donovan M, Gaisa MM. Biomarker P16 predicts progression risk of anal low-grade squamous intraepithelial lesions. AIDS 2018, 32: 2309-2316. PMID: 30005024, PMCID: PMC6862769, DOI: 10.1097/qad.0000000000001957.Peer-Reviewed Original ResearchConceptsLow-grade squamous intraepithelial lesionsAnal low-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsHigh-grade squamous intraepithelial lesionsBiomarker p16Intraepithelial lesionsIndex lesionP16 immunohistochemistryProgression riskHigh-risk human papillomavirus DNACD4 T-cell countFormer smoker statusHistory of condylomaT-cell countsHR-HPV DNAYear of diagnosisHuman papillomavirus DNASemi-quantitative scoring systemAssociation of predictorsLogistic regression modelsOnly significant predictorOrdinal logistic regression modelsClinical outcomesUnderwent surveillanceRetrospective study
2016
Mismatch repair deficiency testing in clinical practice
Buza N, Ziai J, Hui P. Mismatch repair deficiency testing in clinical practice. Expert Review Of Molecular Diagnostics 2016, 16: 591-604. PMID: 26895074, DOI: 10.1586/14737159.2016.1156533.Peer-Reviewed Original ResearchConceptsLynch syndromeDeficiency testingMismatch repair deficiency testingMicrosatellite instabilityMMR deficiency testingMMR gene deficiencyDNA mismatch repair genesCurrent diagnostic algorithmsLynch syndrome familiesProfound genetic instabilityMicrosatellite instability analysisMismatch repair genesEndometrial malignancyClinical managementUltimate diagnosisClinical OncologyClinical practiceClinical testingTumor tissueSyndromeCancer developmentMMR genesDiagnostic algorithmGene deficiencyGermline DNA