2013
Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma
Cai G, Wong R, Chhieng D, Levy GH, Gettinger SN, Herbst RS, Puchalski JT, Homer RJ, Hui P. Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma. Cancer Cytopathology 2013, 121: 500-507. PMID: 23495083, DOI: 10.1002/cncy.21288.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overAnaplastic Lymphoma KinaseBiomarkers, TumorBone NeoplasmsCytodiagnosisDNA, NeoplasmErbB ReceptorsFeasibility StudiesFemaleGene RearrangementHumansIn Situ Hybridization, FluorescenceLiver NeoplasmsLung NeoplasmsMaleMiddle AgedMutationNeoplasm Recurrence, LocalPrognosisProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsReal-Time Polymerase Chain ReactionReceptor Protein-Tyrosine KinasesSoft Tissue NeoplasmsYoung AdultConceptsALK gene rearrangementMetastatic lung adenocarcinomaEGFR mutationsKRAS mutationsMetastatic tumorsEpidermal growth factor receptorLung adenocarcinomaCytological specimensGene rearrangementsMolecular testsMolecular alterationsKirsten rat sarcoma viral oncogene homolog (KRAS) mutationsALK gene rearrangement analysisAnaplastic lymphoma kinase (ALK) gene rearrangementEGFR T790M mutationRat sarcoma viral oncogene homolog mutationsCases of lungT790M mutationImportant therapeutic implicationsFine needle aspiratesGene rearrangement analysisCell block materialGrowth factor receptorRecurrent lungRecurrent adenocarcinoma
2010
Glial Heterotopia of the Uterine Cervix: DNA Genotyping Confirmation of its Fetal Origin
Siddon A, Hui P. Glial Heterotopia of the Uterine Cervix: DNA Genotyping Confirmation of its Fetal Origin. International Journal Of Gynecological Pathology 2010, 29: 394-397. PMID: 20567155, DOI: 10.1097/pgp.0b013e3181c5a7e8.Peer-Reviewed Original ResearchConceptsGlial heterotopiaUterine cervixGlial tissueKlinefelter syndromeFetal originGlial fibrillary acidic proteinMature glial tissueFibrillary acidic proteinDown syndrome fetusesFetal brain tissueEndocervical glandular epitheliumFetal tissue samplesS100 immunohistochemistryCervical polypsCervical lesionsElective terminationIntriguing lesionsPregnancy terminationIdentical genetic profilesSyndrome fetusesGlandular epitheliumSyndromeBrain tissueFirst gestationDown syndrome
2009
Anaplastic oligoastrocytoma in Turcot syndrome
Baehring J, Hui P, Piepmeier J, Bannykh SI. Anaplastic oligoastrocytoma in Turcot syndrome. Journal Of Neuro-Oncology 2009, 95: 293-298. PMID: 19495563, DOI: 10.1007/s11060-009-9928-y.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenosine TriphosphatasesAgedAstrocytomaColorectal Neoplasms, Hereditary NonpolyposisDNA Repair EnzymesDNA-Binding ProteinsDNA, NeoplasmFemaleHumansImmunoenzyme TechniquesMagnetic Resonance ImagingMismatch Repair Endonuclease PMS2MutL Protein Homolog 1MutS Homolog 2 ProteinNuclear ProteinsPedigreePolymerase Chain ReactionConceptsHereditary non-polyposis colorectal cancerTurcot syndromeAnaplastic oligoastrocytomaNon-polyposis colorectal cancerYear old womanHandful of casesColorectal cancerLarge bowelDNA mismatch repair systemOlder womenBrain tumorsTumor DNABody sitesFamilial clusteringGermline mutationsRare variantsSyndromeOligoastrocytomasCancerMismatch repair systemChance occurrenceDetailed molecular dataBowelPathogenesisTumors
2008
Lack of Genetic Association Between Exaggerated Placental Site Reaction and Placental Site Trophoblastic Tumor
Jorge D, Hui P. Lack of Genetic Association Between Exaggerated Placental Site Reaction and Placental Site Trophoblastic Tumor. International Journal Of Gynecological Pathology 2008, 27: 562-567. PMID: 18753963, DOI: 10.1097/pgp.0b013e31816d1d00.Peer-Reviewed Original ResearchSynovial Sarcoma of the Stomach
Makhlouf HR, Ahrens W, Agarwal B, Dow N, Marshalleck JJ, Lee EL, Dotto JE, Hui P, Sobin LH, Oliveira A, Miettinen M. Synovial Sarcoma of the Stomach. The American Journal Of Surgical Pathology 2008, 32: 275-281. PMID: 18223331, DOI: 10.1097/pas.0b013e31812e6a58.Peer-Reviewed Original ResearchConceptsSynovial sarcomaTumor sizeSYT-SSX fusion transcriptsGastric synovial sarcomaGastric primary tumorSpindle cell neoplasmRound cell componentFocal keratinPartial gastrectomyPostoperative radiationMedian ageSegmental resectionVariable prognosisRecurrence 6Immunohistochemical featuresPrimary tumorKIT immunoreactivityMicroscopic calcificationCell neoplasmsTumors 25Differential diagnosisGastrointestinal tractOval lesionTransmural massPatients
2007
Absence of Y chromosome in human placental site trophoblastic tumor
Hui P, Wang HL, Chu P, Yang B, Huang J, Baergen RN, Sklar J, Yang XJ, Soslow RA. Absence of Y chromosome in human placental site trophoblastic tumor. Modern Pathology 2007, 20: 1055-1060. PMID: 17643092, DOI: 10.1038/modpathol.3800941.Peer-Reviewed Original Research
2005
Atypical angiomyolipoma of kidney in a patient with tuberous sclerosis: a case report with p53 gene mutation analysis.
Ma L, Kowalski D, Javed K, Hui P. Atypical angiomyolipoma of kidney in a patient with tuberous sclerosis: a case report with p53 gene mutation analysis. Archives Of Pathology & Laboratory Medicine 2005, 129: 676-9. PMID: 15859641, DOI: 10.5858/2005-129-0676-aaokia.Peer-Reviewed Original ResearchConceptsHMB-45Tuberous sclerosisP53 mutationsPerivascular epithelioid cell tumorCommon benign mesenchymal tumorsFocal p53 immunoreactivityP53 gene mutation analysisSmooth muscle-like cellsEpithelioid cell tumorBenign mesenchymal tumorsMuscle-like cellsGene mutation analysisAtypical angiomyolipomaEpithelioid angiomyolipomaRenal angiomyolipomaCase reportMesenchymal tumorsCell tumorsAML progressionAML casesP53 immunoreactivityFrequent mitosesP53 abnormalitiesAngiomyolipomaEpithelioid cells
2002
Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma)
Hui P, Glusac EJ, Sinard JH, Perkins AS. Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma). Journal Of Cutaneous Pathology 2002, 29: 385-389. PMID: 12139632, DOI: 10.1034/j.1600-0560.2002.290701.x.Peer-Reviewed Original ResearchConceptsCutaneous fibrous histiocytomaDermatofibrosarcoma protuberansFibrous histiocytomaAR allelesCommon benign fibrohistiocytic lesionBenign fibrohistiocytic lesionsReactive fibroblastic proliferationCell typesCases of dermatofibromaAndrogen receptor geneMixed cell typeNeoplastic cell typesHistiocytoid featuresDeep fibrous histiocytomaFemale patientsHistological typeFibrohistiocytic lesionsHistiocytoid cellsInflammatory process