2020
ERas Enhances Resistance to Cisplatin-Induced Apoptosis by Suppressing Autophagy in Gastric Cancer Cell
Tian H, Wang W, Meng X, Wang M, Tan J, Jia W, Li P, Li J, Zhou Q. ERas Enhances Resistance to Cisplatin-Induced Apoptosis by Suppressing Autophagy in Gastric Cancer Cell. Frontiers In Cell And Developmental Biology 2020, 7: 375. PMID: 32083074, PMCID: PMC7005724, DOI: 10.3389/fcell.2019.00375.Peer-Reviewed Original ResearchCisplatin-induced apoptosisResistance to cisplatin-induced apoptosisEpithelial mesenchymal transitionEmbryonic stem cell-expressed RasGastric cancerRas protein familyGC cellsAGS GC cellsGastric cancer cellsCell-expressed RasOutcome of GC patientsProtein familyGC cell linesCancer-related deathsPromote tumorigenicityAKT/mTOR signaling pathwayTumorigenic growthSignaling pathwayEmbryonic stem cellsTreatment of GCBGC-823Growth of embryonic stem cellsCancer cellsCell linesAutophagy process
2011
Reduced Level of Ribonucleotide Reductase R2 Subunits Increases Dependence on Homologous Recombination Repair of Cisplatin-Induced DNA Damage
Lin ZP, Lee Y, Lin F, Belcourt MF, Li P, Cory JG, Glazer PM, Sartorelli AC. Reduced Level of Ribonucleotide Reductase R2 Subunits Increases Dependence on Homologous Recombination Repair of Cisplatin-Induced DNA Damage. Molecular Pharmacology 2011, 80: 1000-1012. PMID: 21875941, PMCID: PMC3228527, DOI: 10.1124/mol.111.074708.Peer-Reviewed Original ResearchConceptsNucleotide excision repairHomologous recombination repairR2 subunitRibonucleotide reductaseRecombination repairCell cycleP53-deficient human colon cancer cellsDNA damageS phaseDepletion of BRCA1Mammalian ribonucleotide reductaseSubsequent S phaseDouble-strand breaksHuman colon cancer cellsP53-deficient cancer cellsSingle-strand gapsCancer cellsCisplatin-induced DNA damageColon cancer cellsCisplatin-DNA lesionsGap-filling synthesisHeteromeric enzymeReplication stressΓ-H2AX inductionDNA repair