2001
Glycosylation and the Immune System
Rudd P, Elliott T, Cresswell P, Wilson I, Dwek R. Glycosylation and the Immune System. Science 2001, 291: 2370-2376. PMID: 11269318, DOI: 10.1126/science.291.5512.2370.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigen-Antibody ReactionsAntigen-Presenting CellsAntigens, CD1Carrier ProteinsCollectinsComplement System ProteinsEndoplasmic ReticulumEpitopesGlycoproteinsGlycosylationHistocompatibility AntigensHumansImmune SystemImmunoglobulinsPolysaccharidesProtein FoldingT-LymphocytesViral Envelope ProteinsConceptsImmune systemMajor histocompatibility complex antigensAntigen-presenting cellsAdaptive immune responsesCellular immune systemHistocompatibility complex antigensHumoral immune systemT cell receptor complexRheumatoid arthritisMannose-binding lectinAutoimmune diseasesCell receptor complexT cellsImmune responseComplex antigensPeptide antigensComplement componentsImmunoglobulin GAntigenKey moleculesReceptor complexSpecific glycoformsGlycoproteinGlycopeptide antigensArthritis
1999
Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules
Mommaas A, Mulder A, Jordens R, Out C, Tan M, Cresswell P, Kluin P, Koning F. Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules. European Journal Of Immunology 1999, 29: 571-580. PMID: 10064073, DOI: 10.1002/(sici)1521-4141(199902)29:02<571::aid-immu571>3.0.co;2-e.Peer-Reviewed Original ResearchConceptsHuman epidermal Langerhans cellsEpidermal Langerhans cellsLangerhans cellsT cellsAntigen-specific T cellsMannose receptorPeripheral blood mononuclear cellsHLA class II moleculesProtein antigensBlood-derived DCsBlood mononuclear cellsAntigen-presenting cellsNaive T cellsDendritic cell lineageClass II moleculesClass II compartmentsFunctional mannose receptorsLymph nodesAntigen uptakeMononuclear cellsMHC classEndocytic capacitySkin damageReceptor-mediated endocytosis pathwayAntigen
1987
An epitope common to HLA class I and class II antigens, Ig light chains, and β2-microglobulin
Lutz P, Cresswell P. An epitope common to HLA class I and class II antigens, Ig light chains, and β2-microglobulin. Immunogenetics 1987, 25: 228-233. PMID: 2437022, DOI: 10.1007/bf00404692.Peer-Reviewed Original ResearchConceptsB-lymphoblastoid cell linesClass I heavy chainsWestern blottingClass I major histocompatibility complex antigensClass II MHC antigensMajor histocompatibility complex antigensClass IHLA class I heavy chainsClass II antigensHistocompatibility complex antigensHLA class IBeta-2-microglobulinLight chainHeavy chainNormal human serumWestern blot analysisMHC antigensII antigensComplex antigensImmunoglobulin light chainsM1 mAbΒ2-microglobulinMonoclonal antibodiesAntigenHuman immunoglobulinAntigen recognition by T lymphocytes
Cresswell P. Antigen recognition by T lymphocytes. Trends In Immunology 1987, 8: 67-69. PMID: 25289464, DOI: 10.1016/0167-5699(87)90843-7.Peer-Reviewed Original ResearchImmune recognition of human major histocompatibility antigens: localization by a comprehensive synthetic strategy of the continuous antigenic sites in the first domain of HLA‐DR2 β chain
Ulrich R, Atassi H, Lutz P, Cresswell P, Atassi M. Immune recognition of human major histocompatibility antigens: localization by a comprehensive synthetic strategy of the continuous antigenic sites in the first domain of HLA‐DR2 β chain. European Journal Of Immunology 1987, 17: 497-502. PMID: 2436923, DOI: 10.1002/eji.1830170410.Peer-Reviewed Original ResearchConceptsAntibody-binding activityHuman major histocompatibility antigensBeta chainMajor histocompatibility antigensAntigenic sitesHistocompatibility antigensImmune recognitionChain antiserumIsolated beta chainsMost antiseraAntiserumPeptide 81Continuous antigenic sitesΒ-chainPeptidesFirst domainHLAImmunodominanceAntigenComprehensive synthetic strategy
1986
Expression of differentiation antigens by hybrids of human lymphoblastoid cells
Howell D, Salter R, Koppelman B, Cresswell P. Expression of differentiation antigens by hybrids of human lymphoblastoid cells. Human Immunology 1986, 17: 443-455. PMID: 3098709, DOI: 10.1016/0198-8859(86)90303-4.Peer-Reviewed Original ResearchConceptsParent cell lineCell linesClass IClass II antigensB lymphocyte antigensClass II histocompatibility antigensLymphocyte differentiation markersT-lymphoblastoid cell lineII antigensHistocompatibility antigensLymphocyte antigenDifferentiation antigensLymphoblastoid cell linesParental antigensHNK-1AntigenMonoclonal antibodiesHuman lymphoblastoid cellsT-LCLDifferentiation markersLymphoblastoid cellsCurrent study
1985
Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
Salter R, Howell D, Cresswell P. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. Immunogenetics 1985, 21: 235-246. PMID: 3872841, DOI: 10.1007/bf00375376.Peer-Reviewed Original ResearchConceptsHLA class IClass II antigen expressionClass II antigensHLA-B antigensClass III antigensAntigen expressionLymphoblastoid cell linesTotal HLA class IHLA class II antigensHLA-A2 antigenHLA-B5 antigenHLA-A antigensB-lymphoblastoid cell linesCell linesHLA-DRHLA-B5HLA-A2B-LCLParental cell lineAntigenEnhanced expressionDecreased amountCEMRChromosome 6
1984
Expression of class I histocompatibility antigens on human T-B lymphoblast hybrids
Howell D, Kostyu D, Ting J, Cresswell P. Expression of class I histocompatibility antigens on human T-B lymphoblast hybrids. Somatic Cell And Molecular Genetics 1984, 10: 217-224. PMID: 6609440, DOI: 10.1007/bf01535244.Peer-Reviewed Original ResearchConceptsClass I histocompatibilityB-LCLLymphoblastoid cell linesB antigensPaucity of HLAHLA class I heavy chainsHLA-B antigensHLA-A antigensB-lymphoblastoid cell linesB antigen expressionClass I heavy chainsAntigen expressionB expressionHLAIndirect immunofluorescenceAntigenLow levelsClass IT-LCLHistocompatibilityCell linesHeavy chain mRNATotal levelsCEMRHeavy chain
1983
Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybrids
Howell D, Hartzman R, Cresswell P. Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybrids. Human Immunology 1983, 8: 167-175. PMID: 6417070, DOI: 10.1016/0198-8859(83)90011-3.Peer-Reviewed Original Research
1981
A human leukocyte antigen identified by a monoclonal antibody
Berger A, Davis J, Cresswell P. A human leukocyte antigen identified by a monoclonal antibody. Human Immunology 1981, 3: 231-245. PMID: 6975769, DOI: 10.1016/0198-8859(81)90020-3.Peer-Reviewed Original ResearchConceptsLeukocyte antigenT cell linesB cell linesB lymphocytesCell linesMonoclonal antibodiesHuman leukocyte antigenPeripheral blood cellsBone marrow cellsAllogeneic cellsT cellsB cellsErythroid seriesMore antigensAntigenHuman leukocytesMarrow cellsBlood cellsNegative populationAntibodiesLymphocytesApproximate molecular weightCellsElectrophoretic mobilityMonocytes
1980
A public HLA antigen associated with HLA-A9, Aw32, and Bw4
Kostyu D, Cresswell P, Amos D. A public HLA antigen associated with HLA-A9, Aw32, and Bw4. Immunogenetics 1980, 10: 433-442. PMID: 22457917, DOI: 10.1007/bf01572579.Peer-Reviewed Original Research
1976
HLA antigens: rabbit antisera reacting with all A series or all B series specificities
Cresswell P, Ayres J. HLA antigens: rabbit antisera reacting with all A series or all B series specificities. European Journal Of Immunology 1976, 6: 82-88. PMID: 786698, DOI: 10.1002/eji.1830060203.Peer-Reviewed Original ResearchConceptsCytotoxicity of HLAHLA alloantiseraHLA antigensA2 substanceHuman peripheral blood lymphocytesPeripheral blood lymphocytesComplement-mediated cytotoxicityType of serumHLA-B12HLA-A2Blood lymphocytesHLA-B7Beta 2microglobulinHLAFragments of rabbitHLA lociCultured cell linesAntigenic determinantsAllelic productsRabbitsCell linesImmune precipitationRabbit antiserumAntigenAntiserum