2013
A novel human CD1d knock-in mouse model demonstrates potent anti-tumor potential of human CD1d-restricted iNKT cells (P5001)
Yuan W, Wen X, Rao P, Cresswell P, Porcelli S, Kim S, Carreño L, Lawrenczyk A. A novel human CD1d knock-in mouse model demonstrates potent anti-tumor potential of human CD1d-restricted iNKT cells (P5001). The Journal Of Immunology 2013, 190: 110.1-110.1. DOI: 10.4049/jimmunol.190.supp.110.1.Peer-Reviewed Original ResearchINKT cellsHuman iNKT cellsAnti-tumor therapyMouse modelHuman iNKT cell responsesPotent anti-tumor functionsHuman CD1dPowerful anti-tumor effectCD1d antigen presentationFunctional iNKT cellsINKT cell responsesInvariant NKT cellsNKT cell developmentExpression of CD4Conventional mouse modelsAnti-tumor functionAntigen presentation pathwayAnti-tumor effectsHuman clinical trialsAnti-tumor potentialNKT cellsClinical trialsAntigen presentationChallenge modelPreclinical assessment
1999
Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells
Tomazin R, Boname J, Hegde N, Lewinsohn D, Altschuler Y, Jones T, Cresswell P, Nelson J, Riddell S, Johnson D. Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells. Nature Medicine 1999, 5: 1039-1043. PMID: 10470081, DOI: 10.1038/12478.Peer-Reviewed Original ResearchConceptsHuman cytomegalovirusT cellsT lymphocytesClass II proteinsMHC class II antigen presentation pathwayMHC class II pathwayClass II antigen presentation pathwayHCMV-infected macrophagesAntigen presentation pathwayClass II pathwayLifelong latent infectionLife-threatening diseaseMonocytes/macrophagesMHC class IImportant host cellsMHC class II proteinsImmune evasion proteinsVirus reactivationHLA-DRLatent reservoirPresent antigensGlial cellsUbiquitous herpesvirusLatent infectionPresentation pathway