1997
Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing
Denzin L, Sant'Angelo D, Hammond C, Surman M, Cresswell P. Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing. Science 1997, 278: 106-109. PMID: 9311912, DOI: 10.1126/science.278.5335.106.Peer-Reviewed Original ResearchConceptsHLA-DOII-like moleculeAntigen processingClass IIHLA-DMMajor histocompatibility complex classMHC class IIHistocompatibility complex classClass II moleculesII-CLIP complexesHLA-DM functionT cell linesB cellsChain-derived peptideAntigenic peptidesImportant modulatorCell linesDM functionInvariant chain-derived peptidesComplex classNegative regulationPeptides
1996
HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules
Denzin L, Hammond C, Cresswell P. HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules. Journal Of Experimental Medicine 1996, 184: 2153-2166. PMID: 8976171, PMCID: PMC2196380, DOI: 10.1084/jem.184.6.2153.Peer-Reviewed Original ResearchConceptsClass II moleculesHLA-DR moleculesHLA-DMDR moleculesMajor histocompatibility complex classAntigenic peptidesEmpty class II moleculesCLIP dissociationHistocompatibility complex classMHC class II compartmentsHLA-DM moleculesClass II compartmentsII-CLIP complexesClass II dimersAlpha beta dimersAntigen processingBeta dimersDR complexesCell linesInvariant chain fragmentComplex classAssociationLow levelsTrafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM
Robbins N, Hammond C, Denzin L, Pan M, Cresswell P. Trafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM. Human Immunology 1996, 45: 13-23. PMID: 8655355, DOI: 10.1016/0198-8859(95)00152-2.Peer-Reviewed Original ResearchConceptsMHC class II moleculesClass II moleculesClass-II-associated invariant chain peptidesMHC-class-II-restricted antigen presentationMajor histocompatibility complex (MHC) class II moleculesMHC class IIInvariant chain peptidePercoll gradientAntigen presentationClass IIHLA-DMAntigenic peptidesInvariant chainPeptide loadingAlpha beta dimersChain peptideImmunoelectron micrographsDM moleculesBeta dimersCompartmentsProteolytic fragmentsEndocytic compartmentsIntracellular compartments
1995
HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading
Denzin L, Cresswell P. HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 1995, 82: 155-165. PMID: 7606781, DOI: 10.1016/0092-8674(95)90061-6.Peer-Reviewed Original Research
1994
In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides
Avva R, Cresswell P. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides. Immunity 1994, 1: 763-774. PMID: 7895165, DOI: 10.1016/s1074-7613(94)80018-9.Peer-Reviewed Original ResearchConceptsHLA-DM expressionDR alpha beta dimersHLA-DR moleculesCLIP dissociationClass II moleculesHLA-DR complexInvariant chain peptideII-peptide complexesPrimary aliphatic aminesResidual fragmentsChain-derived peptideClass IIHLA-DMAliphatic aminesCarboxylic acidsSuch complexesUnbranched hydrocarbonsAlpha beta dimersChain peptideInvariant chain-derived peptidesComplexesVivoCLIP complexBeta dimersDissociation