2001
Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus
Chin K, Cresswell P. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 15125-15130. PMID: 11752458, PMCID: PMC64994, DOI: 10.1073/pnas.011593298.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCells, CulturedCytomegalovirusDNA, ComplementaryHumansInterferon-alphaInterferon-betaMolecular Sequence DataOxidoreductases Acting on CH-CH Group DonorsProtein BiosynthesisProteinsSequence Homology, Amino AcidViral Envelope ProteinsVirus ReplicationMultiple species express thiol oxidoreductases related to GILT
Phan U, Maric M, Dick T, Cresswell P. Multiple species express thiol oxidoreductases related to GILT. Immunogenetics 2001, 53: 342-346. PMID: 11491538, DOI: 10.1007/s002510100323.Peer-Reviewed Original ResearchCathepsin S Regulates the Expression of Cathepsin L and the Turnover of γ-Interferon-inducible Lysosomal Thiol Reductase in B Lymphocytes*
Honey K, Duff M, Beers C, Brissette W, Elliott E, Peters C, Maric M, Cresswell P, Rudensky A. Cathepsin S Regulates the Expression of Cathepsin L and the Turnover of γ-Interferon-inducible Lysosomal Thiol Reductase in B Lymphocytes*. Journal Of Biological Chemistry 2001, 276: 22573-22578. PMID: 11306582, DOI: 10.1074/jbc.m101851200.Peer-Reviewed Original ResearchConceptsB cellsCathepsin SMajor histocompatibility complex (MHC) class II moleculesClass II presentation pathwayT cell responsesPeripheral lymphoid organsCathepsin L proteinClass II moleculesInvariant chain cleavageAntigenic peptide fragmentsDendritic cellsLymphoid organsLysosomal thiol reductaseAntigen presentationPresentation pathwayB lymphocytesCell responsesMature giltsΓ-interferon-inducible lysosomal thiol reductaseInvariant chainThiol reductaseInducible lysosomal thiol reductaseNovel mechanismCathepsin LCells
2000
Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)
Arunachalam B, Phan U, Geuze H, Cresswell P. Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT). Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 745-750. PMID: 10639150, PMCID: PMC15401, DOI: 10.1073/pnas.97.2.745.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBinding SitesCOS CellsDisulfidesDNA, ComplementaryEndosomesEnzyme InductionHumansHydrogen-Ion ConcentrationInterferon-gammaLysosomesMannosephosphatesMicroscopy, ImmunoelectronMolecular Sequence DataMutagenesisOxidation-ReductionProtein Disulfide Reductase (Glutathione)Protein Processing, Post-TranslationalSequence Analysis, DNATumor Cells, CulturedConceptsGamma interferon inducible lysosomal thiol reductaseLysosomal thiol reductaseThiol reductaseDisulfide bondsC-terminal prosequenceEndocytic pathwayThioredoxin familyCysteine residuesDisulfide bond reductionEfficient proteolysisCell typesAmino acidsLysosomal systemEnzymeLysosomesSoluble glycoproteinReductaseActive siteBond reductionAntigen processingImportant roleEnzymatic reductionMutagenesisThioredoxinProsequence
1999
The N‐terminal region of tapasin is required to stabilize the MHC class I loading complex
Bangia N, Lehner P, Hughes E, Surman M, Cresswell P. The N‐terminal region of tapasin is required to stabilize the MHC class I loading complex. European Journal Of Immunology 1999, 29: 1858-1870. PMID: 10382748, DOI: 10.1002/(sici)1521-4141(199906)29:06<1858::aid-immu1858>3.0.co;2-c.Peer-Reviewed Original ResearchAntigen PresentationAntiportersATP Binding Cassette Transporter, Subfamily B, Member 2ATP-Binding Cassette TransportersBase SequenceBeta 2-MicroglobulinBinding SitesBiological Transport, ActiveCalcium-Binding ProteinsCalreticulinCell LineDNA PrimersDrug StabilityHeat-Shock ProteinsHistocompatibility Antigens Class IHumansImmunoglobulinsIsomerasesKineticsMacromolecular SubstancesMembrane Transport ProteinsMolecular ChaperonesProtein BindingProtein Disulfide-IsomerasesRibonucleoproteins
1998
Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC
Herberg J, Sgouros J, Jones T, Copeman J, Humphray S, Sheer D, Cresswell P, Beck S, Trowsdale J. Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. European Journal Of Immunology 1998, 28: 459-467. PMID: 9521053, DOI: 10.1002/(sici)1521-4141(199802)28:02<459::aid-immu459>3.0.co;2-z.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntiportersATP Binding Cassette Transporter, Subfamily B, Member 2ATP-Binding Cassette TransportersBase SequenceCentromereExonsGenes, MHC Class IHistocompatibility Antigens Class IHumansImmunoglobulinsIntronsMembrane Transport ProteinsMiceMolecular Sequence DataPhylogenyRatsConceptsTapasin geneMouse ESTsSyntenic positionsGenomic analysisSeparate exonsGene sequencesDistinct phylogenyEndoplasmic reticulumGenesK locusChromosome 17IgC domainFunctional significanceLociMHC class IClass IHLA-DP locusTAP2 genesEquivalent locationsTAP transporterTapasin moleculePhylogenyIntronsChromosomesESTs
1994
Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells
Denzin L, Robbins N, Carboy-Newcomb C, Cresswell P. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. Immunity 1994, 1: 595-606. PMID: 7600288, DOI: 10.1016/1074-7613(94)90049-3.Peer-Reviewed Original ResearchAntigen PresentationAntigens, Differentiation, B-LymphocyteBase SequenceBiological TransportCell LineCell MembraneFlow CytometryHistocompatibility Antigens Class IIHLA-D AntigensHLA-DR3 AntigenHumansHybrid CellsKineticsMolecular Sequence DataMutationNeoplasm ProteinsPrecipitin TestsSodium Dodecyl SulfateTime FactorsTransfection
1992
Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer
Spies T, Cerundolo V, Colonna M, Cresswell P, Townsend A, DeMars R. Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer. Nature 1992, 355: 644-646. PMID: 1538752, DOI: 10.1038/355644a0.Peer-Reviewed Original Research