1999
Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells
Tomazin R, Boname J, Hegde N, Lewinsohn D, Altschuler Y, Jones T, Cresswell P, Nelson J, Riddell S, Johnson D. Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells. Nature Medicine 1999, 5: 1039-1043. PMID: 10470081, DOI: 10.1038/12478.Peer-Reviewed Original ResearchConceptsHuman cytomegalovirusT cellsT lymphocytesClass II proteinsMHC class II antigen presentation pathwayMHC class II pathwayClass II antigen presentation pathwayHCMV-infected macrophagesAntigen presentation pathwayClass II pathwayLifelong latent infectionLife-threatening diseaseMonocytes/macrophagesMHC class IImportant host cellsMHC class II proteinsImmune evasion proteinsVirus reactivationHLA-DRLatent reservoirPresent antigensGlial cellsUbiquitous herpesvirusLatent infectionPresentation pathway
1998
The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules.
Hammond C, Denzin L, Pan M, Griffith J, Geuze H, Cresswell P. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules. The Journal Of Immunology 1998, 161: 3282-91. PMID: 9759843, DOI: 10.4049/jimmunol.161.7.3282.Peer-Reviewed Original ResearchIntracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class II molecules.
Arunachalam B, Pan M, Cresswell P. Intracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class II molecules. The Journal Of Immunology 1998, 160: 5797-806. PMID: 9637490, DOI: 10.4049/jimmunol.160.12.5797.Peer-Reviewed Original ResearchAllelesAnimalsCell Transformation, ViralElectrophoresis, Polyacrylamide GelFlow CytometryFluorescent Antibody Technique, IndirectHerpesvirus 4, HumanHistocompatibility Antigens Class IIHLA-D AntigensHLA-DR AntigensLysosomesMiceOxidoreductasesOxidoreductases Acting on Sulfur Group DonorsProteinsRabbitsSodium Dodecyl SulfateSurface PropertiesQuantitative Defect in Staphylococcal Enterotoxin A Binding and Presentation by HLA-DM-Deficient T2.AkCells Corrected by Transfection of HLA-DM Genes
Albert L, Denzin L, Ghumman B, Bangia N, Cresswell P, Watts T. Quantitative Defect in Staphylococcal Enterotoxin A Binding and Presentation by HLA-DM-Deficient T2.AkCells Corrected by Transfection of HLA-DM Genes. Cellular Immunology 1998, 183: 42-51. PMID: 9578718, DOI: 10.1006/cimm.1997.1236.Peer-Reviewed Original Research
1997
Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing
Denzin L, Sant'Angelo D, Hammond C, Surman M, Cresswell P. Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing. Science 1997, 278: 106-109. PMID: 9311912, DOI: 10.1126/science.278.5335.106.Peer-Reviewed Original ResearchConceptsHLA-DOII-like moleculeAntigen processingClass IIHLA-DMMajor histocompatibility complex classMHC class IIHistocompatibility complex classClass II moleculesII-CLIP complexesHLA-DM functionT cell linesB cellsChain-derived peptideAntigenic peptidesImportant modulatorCell linesDM functionInvariant chain-derived peptidesComplex classNegative regulationPeptides
1996
HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules
Denzin L, Hammond C, Cresswell P. HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules. Journal Of Experimental Medicine 1996, 184: 2153-2166. PMID: 8976171, PMCID: PMC2196380, DOI: 10.1084/jem.184.6.2153.Peer-Reviewed Original ResearchConceptsClass II moleculesHLA-DR moleculesHLA-DMDR moleculesMajor histocompatibility complex classAntigenic peptidesEmpty class II moleculesCLIP dissociationHistocompatibility complex classMHC class II compartmentsHLA-DM moleculesClass II compartmentsII-CLIP complexesClass II dimersAlpha beta dimersAntigen processingBeta dimersDR complexesCell linesInvariant chain fragmentComplex classAssociationLow levelsTrimeric Interactions of the Invariant Chain and Its Association with Major Histocompatibility Complex Class II αβ Dimers*
Newcomb J, Carboy-Newcomb C, Cresswell P. Trimeric Interactions of the Invariant Chain and Its Association with Major Histocompatibility Complex Class II αβ Dimers*. Journal Of Biological Chemistry 1996, 271: 24249-24256. PMID: 8798670, DOI: 10.1074/jbc.271.39.24249.Peer-Reviewed Original ResearchHLA-DM Is Localized to Conventional and Unconventional MHC Class II–Containing Endocytic Compartments
Pierre P, Denzin L, Hammond C, Drake J, Amigorena S, Cresswell P, Mellman I. HLA-DM Is Localized to Conventional and Unconventional MHC Class II–Containing Endocytic Compartments. Immunity 1996, 4: 229-239. PMID: 8624813, DOI: 10.1016/s1074-7613(00)80431-8.Peer-Reviewed Original ResearchTrafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM
Robbins N, Hammond C, Denzin L, Pan M, Cresswell P. Trafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM. Human Immunology 1996, 45: 13-23. PMID: 8655355, DOI: 10.1016/0198-8859(95)00152-2.Peer-Reviewed Original ResearchConceptsMHC class II moleculesClass II moleculesClass-II-associated invariant chain peptidesMHC-class-II-restricted antigen presentationMajor histocompatibility complex (MHC) class II moleculesMHC class IIInvariant chain peptidePercoll gradientAntigen presentationClass IIHLA-DMAntigenic peptidesInvariant chainPeptide loadingAlpha beta dimersChain peptideImmunoelectron micrographsDM moleculesBeta dimersCompartmentsProteolytic fragmentsEndocytic compartmentsIntracellular compartments
1995
HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading
Denzin L, Cresswell P. HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 1995, 82: 155-165. PMID: 7606781, DOI: 10.1016/0092-8674(95)90061-6.Peer-Reviewed Original Research
1994
Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells
Denzin L, Robbins N, Carboy-Newcomb C, Cresswell P. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. Immunity 1994, 1: 595-606. PMID: 7600288, DOI: 10.1016/1074-7613(94)90049-3.Peer-Reviewed Original ResearchAntigen PresentationAntigens, Differentiation, B-LymphocyteBase SequenceBiological TransportCell LineCell MembraneFlow CytometryHistocompatibility Antigens Class IIHLA-D AntigensHLA-DR3 AntigenHumansHybrid CellsKineticsMolecular Sequence DataMutationNeoplasm ProteinsPrecipitin TestsSodium Dodecyl SulfateTime FactorsTransfectionAntigen Presentation: Getting peptides into MHC class II molecules
Cresswell P. Antigen Presentation: Getting peptides into MHC class II molecules. Current Biology 1994, 4: 541-543. PMID: 7922377, DOI: 10.1016/s0960-9822(00)00119-6.Peer-Reviewed Original Research
1992
Chemistry and functional role of the invariant chain
Cresswell P. Chemistry and functional role of the invariant chain. Current Opinion In Immunology 1992, 4: 87-92. PMID: 1317713, DOI: 10.1016/0952-7915(92)90131-w.Peer-Reviewed Original Research
1991
Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain
Roche P, Marks M, Cresswell P. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain. Nature 1991, 354: 392-394. PMID: 1956401, DOI: 10.1038/354392a0.Peer-Reviewed Original Research
1990
Transport and expression of HLA class-II glycoproteins
Cresswell P, Blum J, Davis J, Marks M. Transport and expression of HLA class-II glycoproteins. Immunologic Research 1990, 9: 190-199. PMID: 2121862, DOI: 10.1007/bf02918178.Peer-Reviewed Original Research
1987
Localization of an epitope of beta-2 microglobulin that is shared with other members of the immunoglobulin superfamily
Parham P, Lutz P, Cresswell P. Localization of an epitope of beta-2 microglobulin that is shared with other members of the immunoglobulin superfamily. Immunogenetics 1987, 26: 323-326. PMID: 2443449, DOI: 10.1007/bf00346533.Peer-Reviewed Original ResearchImmune recognition of human major histocompatibility antigens: localization by a comprehensive synthetic strategy of the continuous antigenic sites in the first domain of HLA‐DR2 β chain
Ulrich R, Atassi H, Lutz P, Cresswell P, Atassi M. Immune recognition of human major histocompatibility antigens: localization by a comprehensive synthetic strategy of the continuous antigenic sites in the first domain of HLA‐DR2 β chain. European Journal Of Immunology 1987, 17: 497-502. PMID: 2436923, DOI: 10.1002/eji.1830170410.Peer-Reviewed Original ResearchConceptsAntibody-binding activityHuman major histocompatibility antigensBeta chainMajor histocompatibility antigensAntigenic sitesHistocompatibility antigensImmune recognitionChain antiserumIsolated beta chainsMost antiseraAntiserumPeptide 81Continuous antigenic sitesΒ-chainPeptidesFirst domainHLAImmunodominanceAntigenComprehensive synthetic strategyRegulation of HLA Class I and Class II antigen expression
Cresswell P. Regulation of HLA Class I and Class II antigen expression. British Medical Bulletin 1987, 43: 66-80. PMID: 3315102, DOI: 10.1093/oxfordjournals.bmb.a072177.Peer-Reviewed Original ResearchConceptsCell surfaceRegulatory genesTranscriptional levelHybridisation experimentsIntracellular transportThird glycoproteinHeterodimeric glycoproteinCell typesChondroitin sulfate proteoglycanEfficient assemblyCell linesSulfate proteoglycanEnhanced expressionT cell linesGenesClass IExpressionTissue distributionRegulationLymphoblastoid linesGlycoproteinUnusual complexityClass I moleculesInvariant chainBiosynthesis