2000
Interaction of Human Immunodeficiency Virus Type 2 Vpx and Invariant Chain
Pancio H, Vander Heyden N, Kosuri K, Cresswell P, Ratner L. Interaction of Human Immunodeficiency Virus Type 2 Vpx and Invariant Chain. Journal Of Virology 2000, 74: 6168-6172. PMID: 10846101, PMCID: PMC112116, DOI: 10.1128/jvi.74.13.6168-6172.2000.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, Differentiation, B-LymphocyteBinding SitesHeLa CellsHistocompatibility Antigens Class IIHIV-2HumansNuclear ProteinsSaccharomyces cerevisiaeTrans-ActivatorsTransfectionTwo-Hybrid System TechniquesViral Regulatory and Accessory ProteinsConceptsMajor histocompatibility complex class II antigen presentationHuman immunodeficiency virus type 2Class II antigen presentationHIV-2 VpxSimian immunodeficiency virusInvariant chainVirus type 2Immunodeficiency virusAntigen presentationVirion-associated proteinType 2VpxInfected cellsCellsFusion proteinCellular proteinsProteinS-transferase fusion protein
1998
Proteases, processing, and thymic selection.
Cresswell P. Proteases, processing, and thymic selection. Science 1998, 280: 394-5. PMID: 9575085, DOI: 10.1126/science.280.5362.394.Peer-Reviewed Original ResearchQuantitative Defect in Staphylococcal Enterotoxin A Binding and Presentation by HLA-DM-Deficient T2.AkCells Corrected by Transfection of HLA-DM Genes
Albert L, Denzin L, Ghumman B, Bangia N, Cresswell P, Watts T. Quantitative Defect in Staphylococcal Enterotoxin A Binding and Presentation by HLA-DM-Deficient T2.AkCells Corrected by Transfection of HLA-DM Genes. Cellular Immunology 1998, 183: 42-51. PMID: 9578718, DOI: 10.1006/cimm.1997.1236.Peer-Reviewed Original Research
1997
Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing
Denzin L, Sant'Angelo D, Hammond C, Surman M, Cresswell P. Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing. Science 1997, 278: 106-109. PMID: 9311912, DOI: 10.1126/science.278.5335.106.Peer-Reviewed Original ResearchConceptsHLA-DOII-like moleculeAntigen processingClass IIHLA-DMMajor histocompatibility complex classMHC class IIHistocompatibility complex classClass II moleculesII-CLIP complexesHLA-DM functionT cell linesB cellsChain-derived peptideAntigenic peptidesImportant modulatorCell linesDM functionInvariant chain-derived peptidesComplex classNegative regulationPeptides
1996
Trimeric Interactions of the Invariant Chain and Its Association with Major Histocompatibility Complex Class II αβ Dimers*
Newcomb J, Carboy-Newcomb C, Cresswell P. Trimeric Interactions of the Invariant Chain and Its Association with Major Histocompatibility Complex Class II αβ Dimers*. Journal Of Biological Chemistry 1996, 271: 24249-24256. PMID: 8798670, DOI: 10.1074/jbc.271.39.24249.Peer-Reviewed Original ResearchAntigens, Differentiation, B-LymphocyteCell LineCross-Linking ReagentsEndopeptidase KHistocompatibility Antigens Class IIHLA-D AntigensHumansMolecular WeightOligosaccharidesPeptide FragmentsInvariant Chain Structure and MHC Class II Function
Cresswell P. Invariant Chain Structure and MHC Class II Function. Cell 1996, 84: 505-507. PMID: 8598037, DOI: 10.1016/s0092-8674(00)81025-9.Peer-Reviewed Original ResearchAnimalsAntigens, CDAntigens, Differentiation, B-LymphocyteHistocompatibility Antigens Class IIHumansProtein ConformationTrafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM
Robbins N, Hammond C, Denzin L, Pan M, Cresswell P. Trafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM. Human Immunology 1996, 45: 13-23. PMID: 8655355, DOI: 10.1016/0198-8859(95)00152-2.Peer-Reviewed Original ResearchConceptsMHC class II moleculesClass II moleculesClass-II-associated invariant chain peptidesMHC-class-II-restricted antigen presentationMajor histocompatibility complex (MHC) class II moleculesMHC class IIInvariant chain peptidePercoll gradientAntigen presentationClass IIHLA-DMAntigenic peptidesInvariant chainPeptide loadingAlpha beta dimersChain peptideImmunoelectron micrographsDM moleculesBeta dimersCompartmentsProteolytic fragmentsEndocytic compartmentsIntracellular compartments
1995
HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading
Denzin L, Cresswell P. HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 1995, 82: 155-165. PMID: 7606781, DOI: 10.1016/0092-8674(95)90061-6.Peer-Reviewed Original ResearchMolecular Requirements for the Interaction of Class II Major Histocompatibility Complex Molecules and Invariant Chain with Calnexin (∗)
Arunachalam B, Cresswell P. Molecular Requirements for the Interaction of Class II Major Histocompatibility Complex Molecules and Invariant Chain with Calnexin (∗). Journal Of Biological Chemistry 1995, 270: 2784-2790. PMID: 7852350, DOI: 10.1074/jbc.270.6.2784.Peer-Reviewed Original Research
1994
In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides
Avva R, Cresswell P. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides. Immunity 1994, 1: 763-774. PMID: 7895165, DOI: 10.1016/s1074-7613(94)80018-9.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid SequenceAntigens, Differentiation, B-LymphocyteBinding SitesCell LineGene Transfer TechniquesHistocompatibility Antigens Class IIHLA-DR AntigensMolecular Sequence DataMutationProtein BindingConceptsHLA-DM expressionDR alpha beta dimersHLA-DR moleculesCLIP dissociationClass II moleculesHLA-DR complexInvariant chain peptideII-peptide complexesPrimary aliphatic aminesResidual fragmentsChain-derived peptideClass IIHLA-DMAliphatic aminesCarboxylic acidsSuch complexesUnbranched hydrocarbonsAlpha beta dimersChain peptideInvariant chain-derived peptidesComplexesVivoCLIP complexBeta dimersDissociationAssembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells
Denzin L, Robbins N, Carboy-Newcomb C, Cresswell P. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. Immunity 1994, 1: 595-606. PMID: 7600288, DOI: 10.1016/1074-7613(94)90049-3.Peer-Reviewed Original ResearchAntigen PresentationAntigens, Differentiation, B-LymphocyteBase SequenceBiological TransportCell LineCell MembraneFlow CytometryHistocompatibility Antigens Class IIHLA-D AntigensHLA-DR3 AntigenHumansHybrid CellsKineticsMolecular Sequence DataMutationNeoplasm ProteinsPrecipitin TestsSodium Dodecyl SulfateTime FactorsTransfection
1991
Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain
Roche P, Marks M, Cresswell P. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain. Nature 1991, 354: 392-394. PMID: 1956401, DOI: 10.1038/354392a0.Peer-Reviewed Original Research