1998
A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells
Garabedian E, Humphrey P, Gordon J. A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 15382-15387. PMID: 9860977, PMCID: PMC28051, DOI: 10.1073/pnas.95.26.15382.Peer-Reviewed Original ResearchConceptsMetastatic prostate cancerProstatic intraepithelial neoplasiaTransgenic mouse modelProstate cancerIntraepithelial neoplasiaMouse modelNeuroendocrine cellsHuman prostate cancerNeuroendocrine cell lineagesWeeks of ageNeuroendocrine differentiationSimian virus 40 T antigenLocal invasionMouse prostateCancerNeoplasiaProstateWeeksT antigenCell lineagesTransgene expressionMultiple pedigreesCellsMetastasisAndrogens
1997
Unusual Histologic Types of High-Grade Prostatic Intraepithelial Neoplasia
Reyes A, Swanson P, Carbone J, Humphrey P. Unusual Histologic Types of High-Grade Prostatic Intraepithelial Neoplasia. The American Journal Of Surgical Pathology 1997, 21: 1215-1222. PMID: 9331295, DOI: 10.1097/00000478-199710000-00013.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaSignet ring cellsSmall cell carcinoma cellsProstatic intraepithelial neoplasiaProstate-specific antigenInvasive carcinomaIntraepithelial neoplasiaPrimary signet-ring cell carcinomaGrade prostatic intraepithelial neoplasiaSignet ring cell carcinomaCases of HGPINCarcinoma cellsNeuron-specific enolaseProstatic cell typesUnusual histologic typeSmall cell neuroendocrineGlandular epithelial cellsArchitectural growth patternIntraepithelial proliferationMucinous distensionCell typesMucinous featuresStrength of associationHistologic typeCell carcinomaThe Significance of Intraluminal Crystalloids in Benign Prostatic Glands on Needle Biopsy
Henneberry J, Kahane H, Humphrey P, Keetch D, Epstein J. The Significance of Intraluminal Crystalloids in Benign Prostatic Glands on Needle Biopsy. The American Journal Of Surgical Pathology 1997, 21: 725-728. PMID: 9199652, DOI: 10.1097/00000478-199706000-00014.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaProstatic intraepithelial neoplasiaRepeat biopsyNeedle biopsyBenign glandsIntraluminal crystalloidsIntraepithelial neoplasiaBiopsy resultsSerum prostatic specific antigen (PSA) levelsSerum prostate-specific antigen valuesProstatic-specific antigen levelProstate-specific antigen valuesConsecutive needle biopsiesSpecific antigen levelsBenign prostatic glandsIncidence of cancerJohns Hopkins HospitalProstate biopsy resultsDianon SystemsConcurrent carcinomaSubsequent biopsyFirst biopsyAntigen levelsCystoprostatectomy specimensAntigen values
1996
Repeat biopsy strategy in men with isolated prostatic intraepithelial neoplasia on prostate needle biopsy.
Shepherd D, Keetch D, Humphrey P, Smith D, Stahl D. Repeat biopsy strategy in men with isolated prostatic intraepithelial neoplasia on prostate needle biopsy. Journal Of Urology 1996, 156: 460-2; discussion 462-3. PMID: 8683703, DOI: 10.1097/00005392-199608000-00038.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaProstatic intraepithelial neoplasiaIntraepithelial neoplasiaRepeat biopsyNeedle biopsyBiopsy techniqueSide of cancerProstate needle biopsyLocation of cancerInitial biopsySystematic biopsyMen 31Biopsy strategyBiopsyNeoplasiaCancerProstateQuadrant locationStrongest predictorPatientsMenSame sideMalignancyDiseaseRepeat Biopsy Strategy in Men with Isolated Prostatic Intraepithelial Neoplasia on Prostate Needle Biopsy
Shepherd D, Keetch D, Humphrey P, Smith D, Stahl D. Repeat Biopsy Strategy in Men with Isolated Prostatic Intraepithelial Neoplasia on Prostate Needle Biopsy. Journal Of Urology 1996, 156: 460-463. DOI: 10.1016/s0022-5347(01)65881-6.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaProstatic intraepithelial neoplasiaIntraepithelial neoplasiaRepeat biopsyNeedle biopsyBiopsy techniqueSide of cancerProstate needle biopsyLocation of cancerPercent of casesInitial biopsySystematic biopsyMen 31Biopsy strategyBiopsyNeoplasiaCancerProstateQuadrant locationPatientsStrongest predictorMenSame sideMalignancy
1995
Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate
Keetch D, Humphrey P, Stahl D, Smith D, Catalona W. Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate. Journal Of Urology 1995, 154: 347-351. DOI: 10.1016/s0022-5347(01)67044-7.Peer-Reviewed Original ResearchConceptsProstatic intraepithelial neoplasiaHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaSerum PSA concentrationRepeat biopsyIntraepithelial neoplasiaProstate needle biopsyProstate-specific antigenNeedle biopsyInitial biopsyProstate cancerNumber of fociElevated serum PSA concentrationInitial prostate needle biopsyPSA concentrationMen 50 yearsPredictors of cancerDigital rectal examinationInitial biopsy specimenCancer detection rateFinding of cancerSignificance of gradeClinical followupPSA densityPatient ageMorphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate
Keetch D, Humphrey P, Stahl D, Smith D, Catalona W. Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate. Journal Of Urology 1995, 154: 347-351.. PMID: 7541850, DOI: 10.1097/00005392-199508000-00003.Peer-Reviewed Original ResearchConceptsProstatic intraepithelial neoplasiaHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaSerum PSA concentrationRepeat biopsyIntraepithelial neoplasiaProstate needle biopsyProstate-specific antigenNeedle biopsyInitial biopsyProstate cancerNumber of fociElevated serum PSA concentrationInitial prostate needle biopsyPSA concentrationMen 50 yearsPredictors of cancerDigital rectal examinationInitial biopsy specimenCancer detection rateFinding of cancerSignificance of gradeClinical followupPSA densityPatient ageInterobserver Reproducibility in the Diagnosis of Prostatic Intraepithelial Neoplasia
Epstein J, Grignon D, Humphrey P, McNeal J, Sesterhenn I, Troncoso P, Wheeler T. Interobserver Reproducibility in the Diagnosis of Prostatic Intraepithelial Neoplasia. The American Journal Of Surgical Pathology 1995, 19: 873-886. PMID: 7611534, DOI: 10.1097/00000478-199508000-00002.Peer-Reviewed Original ResearchConceptsHigh-grade PINLow-grade PINInterobserver reproducibilityProstatic intraepithelial neoplasiaSmall atypical glandsBenign prostate tissueIntraepithelial neoplasiaSame histologyAtypical glandsBiopsy materialProminent nucleoliUniform diagnosisCribriform glandsProstate tissueCancerLesionsLevel of agreementDiagnostic issuesUniform agreementPathologistsGlandDiagnosisConsecutive examplesBiopsyGroup
1993
Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma
Ibrahim S, Lightner V, Ventimiglia J, Ibrahim G, Walther P, Bigner D, Humphrey P. Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. Human Pathology 1993, 24: 982-989. PMID: 7504654, DOI: 10.1016/0046-8177(93)90112-t.Peer-Reviewed Original ResearchConceptsWestern blot analysisIntraepithelial neoplasiaCarcinoma cell linesProstatic hyperplasiaProstatic tissueBlot analysisAdult prostatic tissuesMetastatic prostatic carcinomaGrade of adenocarcinomaHuman prostatic carcinoma cell linesBone marrow samplesProstatic carcinoma cell linesHuman prostate tissueCell linesExpression of tenascinConnective tissue frameworkLymph nodesHistologic gradeProstatic carcinomaStromal alterationsTenascin immunoreactivityMarrow samplesStrong immunoreactivityStromal immunoreactivityProstate tissue