2015
NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence
Manda K, Tripathi P, Hsi A, Ning J, Ruzinova M, Liapis H, Bailey M, Zhang H, Maher C, Humphrey P, Andriole G, Ding L, You Z, Chen F. NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence. Oncogene 2015, 35: 3282-3292. PMID: 26477312, PMCID: PMC5012433, DOI: 10.1038/onc.2015.389.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell LineCell Line, TumorCell ProliferationCell Transformation, NeoplasticCellular SenescenceCytokinesGene Expression Regulation, NeoplasticHumansImmunohistochemistryMaleMice, KnockoutMice, NudeMice, TransgenicNFATC Transcription FactorsProstateProstatic NeoplasmsPTEN PhosphohydrolaseReverse Transcriptase Polymerase Chain ReactionTransplantation, HomologousTumor Cells, CulturedTumor MicroenvironmentConceptsProstate tumorigenesisHuman PCaNFATc1 activationNon-tumorigenic prostate cellsActivated T cells c1Cultured PCa cellsT cells c1Cellular senescenceRole of NFATc1Number of cytokinesActivation of NFATc1Proinflammatory cytokinesPCa cellsProstate cancerProstatic adenocarcinomaLuminal epitheliumMouse prostateCells c1Normal prostateOncogenic roleOncogene c-mycProstate tissueProstate cellsSoluble factorsNuclear factor
1994
Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells.
Day M, Zhao X, Wu S, Swanson P, Humphrey P. Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells. Molecular Cancer Research 1994, 5: 735-41. PMID: 7947388.Peer-Reviewed Original ResearchMeSH KeywordsAlkaloidsAndrogensApoptosisCarcinomaDNA DamageDNA-Binding ProteinsDNA, NeoplasmEarly Growth Response Protein 1Enzyme InductionGene Expression Regulation, NeoplasticHumansImmediate-Early ProteinsMaleNeoplasms, Hormone-DependentProstatic NeoplasmsProtein KinasesProto-Oncogene Proteins c-fosStaurosporineTetradecanoylphorbol AcetateTranscription FactorsTranscriptional ActivationTumor Cells, CulturedConceptsTranscription factor NGFIPhorbol ester-induced apoptosisC-fos gene activationEarly transcriptional regulationKinase signal transductionC-fosProtein kinase activatorsProstate cellsTranscriptional regulationGene activationSignal transductionProtein kinaseInduction of deathKinase activatorLNCaP cellsProstate cancer cellsProstate linesApoptotic bodiesCell deathDNA ladderTransient activationTransient inductionIntracellular pathwaysTPA-induced expressionNGFI