2015
NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence
Manda K, Tripathi P, Hsi A, Ning J, Ruzinova M, Liapis H, Bailey M, Zhang H, Maher C, Humphrey P, Andriole G, Ding L, You Z, Chen F. NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence. Oncogene 2015, 35: 3282-3292. PMID: 26477312, PMCID: PMC5012433, DOI: 10.1038/onc.2015.389.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell LineCell Line, TumorCell ProliferationCell Transformation, NeoplasticCellular SenescenceCytokinesGene Expression Regulation, NeoplasticHumansImmunohistochemistryMaleMice, KnockoutMice, NudeMice, TransgenicNFATC Transcription FactorsProstateProstatic NeoplasmsPTEN PhosphohydrolaseReverse Transcriptase Polymerase Chain ReactionTransplantation, HomologousTumor Cells, CulturedTumor MicroenvironmentConceptsProstate tumorigenesisHuman PCaNFATc1 activationNon-tumorigenic prostate cellsActivated T cells c1Cultured PCa cellsT cells c1Cellular senescenceRole of NFATc1Number of cytokinesActivation of NFATc1Proinflammatory cytokinesPCa cellsProstate cancerProstatic adenocarcinomaLuminal epitheliumMouse prostateCells c1Normal prostateOncogenic roleOncogene c-mycProstate tissueProstate cellsSoluble factorsNuclear factor
2014
PD19-12 MODIFIED GLEASON GRADE OF PROSTATIC ADENOCARCINOMAS DETECTED IN THE PROSTATE, LUNG, COLORECTAL, AND OVARIAN CANCER SCREENING TRIAL
Humphrey P, Strother M, Grubb R, Hickey T, Korch M, Riley T, Mabie J, Bellinger A, Andriole G. PD19-12 MODIFIED GLEASON GRADE OF PROSTATIC ADENOCARCINOMAS DETECTED IN THE PROSTATE, LUNG, COLORECTAL, AND OVARIAN CANCER SCREENING TRIAL. Journal Of Urology 2014, 191: e550. DOI: 10.1016/j.juro.2014.02.1531.Peer-Reviewed Original Research
2006
Immunohistochemistry in the diagnosis of minimal prostate cancer
Hameed O, Humphrey P. Immunohistochemistry in the diagnosis of minimal prostate cancer. Diagnostic Histopathology 2006, 12: 279-291. DOI: 10.1016/j.cdip.2006.05.003.Peer-Reviewed Original ResearchBasal cell markersProstatic adenocarcinomaProstate needle biopsy tissueCell markersMinimal prostate cancerNeedle biopsy tissueEosin-stained sectionsCytokeratin 5/6Invasive carcinomaProstatic lesionsProstate cancerDiagnostic yieldBenign mimickersBiopsy tissueImmunohistochemistryConcurrent useAdenocarcinomaDiagnosisBasal cellsAntibodiesMarkers
2000
Minimal Adenocarcinoma in Prostate Needle Biopsy Tissue
Thorson P, Humphrey P. Minimal Adenocarcinoma in Prostate Needle Biopsy Tissue. American Journal Of Clinical Pathology 2000, 114: 896-909. PMID: 11338479, DOI: 10.1309/kvpx-c1em-142l-1m6w.Peer-Reviewed Original ResearchConceptsNeedle biopsy tissueProstate needle biopsy tissueMinor diagnostic criteriaBiopsy tissueProstatic adenocarcinomaDiagnostic criteriaMinimal adenocarcinomaHigh-grade prostatic intraepithelial neoplasiaAtypical small acinar proliferationFocal glandular atypiaValuable adjunctive studySmall acinar proliferationProstatic intraepithelial neoplasiaAtypical adenomatous hyperplasiaConstellation of findingsIntermediate histologic gradeMajor diagnostic challengeWhole prostate gland
1998
Pseudohyperplastic Prostatic Adenocarcinoma
Humphrey P, Kaleem Z, Swanson P, Vollmer R. Pseudohyperplastic Prostatic Adenocarcinoma. The American Journal Of Surgical Pathology 1998, 22: 1239-1246. PMID: 9777986, DOI: 10.1097/00000478-199810000-00009.Peer-Reviewed Original ResearchConceptsCases of adenocarcinomaProstatic adenocarcinomaHyperplastic featuresNeedle biopsyProstate carcinoma growthUsual epithelial hyperplasiaProstatic needle biopsyLow Gleason scoreLow-grade carcinomaRadical prostatectomy specimensRadical prostatectomy tissueGleason pattern 2Cystic dilatationPathologic stagePrognostic implicationsTumor sizeGleason scoreHistologic gradePapillary infoldingsRadical prostatectomyUsual hyperplasiaHistologic variantsPrognostic informationProstatic carcinomaCarcinomatous fociProstatic Adenocarcinoma With Atrophic Features: A Study of 202 Consecutive Completely Embedded Radical Prostatectomy Specimens
Kaleem Z, Swanson P, Vollmer R, Humphrey P. Prostatic Adenocarcinoma With Atrophic Features: A Study of 202 Consecutive Completely Embedded Radical Prostatectomy Specimens. American Journal Of Clinical Pathology 1998, 109: 695-703. PMID: 9620026, DOI: 10.1093/ajcp/109.6.695.Peer-Reviewed Original ResearchConceptsAtrophic featuresProstatic adenocarcinomaRadical prostatectomy specimensProstatic carcinomaAtrophic carcinomaProliferation indexProstatectomy specimensCarcinoma volumeUsual prostatic adenocarcinomaInfiltrative growth patternMean proliferation indexKi-67 immunolabelingBiotin nick end labelingRadical prostatectomy casesProstatic adenocarcinoma casesGleason grade 3Nick end labelingAtrophic patternUntreated patientsAtrophic changesPathologic stagePrognostic implicationsGlandular atrophyHistologic gradeAdenocarcinoma cases
1990
Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens
Humphrey P, Vollmer R. Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens. Human Pathology 1990, 21: 799-804. PMID: 2387573, DOI: 10.1016/0046-8177(90)90048-a.Peer-Reviewed Original ResearchConceptsHistologic gradeTumor extentProstatectomy specimensTumor progressionPatient survivalProstatic carcinomaIntraglandular tumor extentExtent of tumorProportional hazards modelLogistic regression analysisSignificant prognosticatorPoor outcomeProstatic adenocarcinomaSurvival timeHazards modelProstatic tissueProstate glandEntire prostateProstate tissueConcurrent useTumorsCarcinomaProstateInterobserver agreement valuesProgression